The metabolic syndrome in children and adolescents: a clinician's guide.

This article reviews the components of the metabolic syndrome, the theory behind the combined negative effects of insulin resistance and obesity and discusses the clinical utility of this concept in pediatrics. The latest diagnostic criteria for obesity, dyslipidemia and hypertension in children and adolescents as well as management and prevention strategies are also discussed.

Response and persistence of antibodies to PRP-T and DTwP vaccines with concomitant administration of conjugate vaccines.

We first studied the immunogenicity of PRP-T and DTwP vaccines in Filipino infants given at 6, 10 and 14 weeks concomitantly with either an aluminum adjuvanted eleven-valent pneumococcal conjugate vaccine (11PncTD) or a meningococcal diphtheria-conjugated vaccine as compared to a control group that received only DTwP/PRP-T. The GMCs and proportions of infants achieving protective antibody concentrations to DTwP and PRP-T vaccine antigens were similar among the groups. In the second phase, the control group received 11PncTD at 18 weeks and the antibody concentrations were measured at 9 months in all children; 11PncTD induced a booster response to diphtheria in the control group.