APC promoter hypermethylation is an early event in endometrial tumorigenesis.

The aim of the current study was to investigate the role of promoter methylation of adenomatous polyposis coli (APC) and epithelial cadherin (E-cadherin) genes in endometrial tumorigenesis. The methylation status of both genes was investigated in 43 cases of normal endometrium, 21 simple hyperplasia, 17 atypical hyperplasia, and 86 endometrial carcinoma (EC). Additionally, the methylation pattern of both genes was analyzed in 24 primary ECs and their corresponding metastases.

P16 alterations increase the metastatic potential of endometrial carcinoma.

Objective: The aim of this study was to investigate the role of p16 in tumorigenesis of endometrial carcinoma (EC).

Methods: Expression of p16 protein was analyzed using immunohistochemistry. The methylation status of p16 promoter region was determined by methylation-specific PCR.