Publications by authors named "Chris Suszczynski"
Article Synopsis
- Researchers utilized Hyperpolarized C Magnetic Resonance Imaging (MRI) for the first time to investigate the uptake and metabolism of [2-C]pyruvate in the human brain, aiming to reveal new insights into cerebral energy metabolism.
- The process involved injecting HP [2-C]pyruvate into five healthy volunteers and capturing dynamic brain images using a specialized imaging technique that provided whole brain coverage in just one minute.
- The study quantified metabolic ratios and conversion rates between pyruvate and its metabolites, lactate and glutamate, to simultaneously analyze both glycolytic and oxidative metabolism from a single injection.
We developed methods for the preparation of hyperpolarized (HP) sterile [2-C]pyruvate to test its feasibility in first-ever human NMR studies following FDA-IND & IRB approval. Spectral results using this MR stable-isotope imaging approach demonstrated the feasibility of investigating human cerebral energy metabolism by measuring the dynamic conversion of HP [2-C]pyruvate to [2-C]lactate and [5-C]glutamate in the brain of four healthy volunteers. Metabolite kinetics, signal-to-noise (SNR) and area-under-curve (AUC) ratios, and calculated [2-C]pyruvate to [2-C]lactate conversion rates (k) were measured and showed similar but not identical inter-subject values.
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