Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells.

Background: Diabetes is a disease affecting over 500 million people globally due to insulin insufficiency or insensitivity. For individuals with type 1 diabetes, pancreatic islet transplantation can help regulate their blood glucose levels. However, the scarcity of cadaveric donor islets limits the number of people that could receive this therapy.

The biomechanics of concussive helmet-to-ground impacts in the National Football league.

This paper presents a detailed characterization of helmet-to-ground impacts in the National Football League. Video analysis was performed for 16 head-to-ground impacts that caused concussions. Average resultant closing velocity was 8.

Relative Motion Between the Helmet and the Head in Football Impact Test.

Approximately 1.6-3.8 million sports-related traumatic brain injuries occur each year in the U.

Validation of a videogrammetry technique for analysing American football helmet kinematics.

Professional American football games are recorded in digital video with multiple cameras, often at high resolution and high frame rates. The purpose of this study was to evaluate the accuracy of a videogrammetry technique to calculate translational and rotational helmet velocity before, during and after a helmet impact. In total, 10 football impacts were staged in a National Football League (NFL) stadium by propelling helmeted 50th percentile male crash test dummies into each other or the ground at speeds and orientations representative of concussive impacts for NFL players.

The Athletic Shoe in Football.

Background: Foot and ankle injuries are common in sports, particularly in cleated athletes. Traditionally, the athletic shoe has not been regarded as a piece of protective equipment but rather as a part of the uniform, with a primary focus on performance and subjective feedback measures of comfort. Changes in turf and shoe design have poorly understood implications on the health and safety of players.

Implications of Functional Capacity Loss and Fatality for Vehicle Safety Prioritization.

Objective: We investigate the use of the Functional Capacity Index (FCI) as a tool for establishing vehicle safety priorities by comparing the life year burden of injuries to the burden of fatality in frontal and side automotive crashes. We demonstrate FCI's utility by investigating in detail the resulting disabling injuries and their life year costs.

Methods: We selected occupants in the 2000-2013 NASS-CDS database involved in frontal and side crashes, merged their injuries with FCI, and then used the merged data to estimate each occupant's overall functional loss.

BioTab--a new method for analyzing and documenting injury causation in motor-vehicle crashes.

Objective: To describe a new method for analyzing and documenting the causes of injuries in motor vehicle crashes that has been implemented since 2005 in cases investigated by the Crash Injury Research Engineering Network (CIREN).

Methods: The new method, called BioTab, documents injury causation using evidence from in-depth crash investigations. BioTab focuses on developing injury causation scenarios (ICSs) that document all factors considered essential for an injury to have occurred as well as factors that contributed to the likelihood and/or severity of an injury.

Thoracic response to dynamic, non-impact loading from a hub, distributed belt, diagonal belt, and double diagonal belts.

This paper presents thoracic response corridors developed using fifteen post-mortem human subjects (PMHS) subjected to single and double diagonal belt, distributed, and hub loading on the anterior thorax. We believe this is the first study to quantify the force-deflection response of the same thorax to different loading conditions using dynamic, non-impact, restraint-like loading. Subjects were positioned supine on a table and a hydraulic master-slave cylinder arrangement was used with a high-speed materials testing machine to provide controlled chest deflection at a rate similar to that experienced by restrained PMHS in a 48-km/h sled test.