Publications by authors named "Chris Shamatutu"
qSOFA does not predict bacteremia in patients with severe manifestations of sepsis.
J Assoc Med Microbiol Infect Dis Can
November 2022
Background: Bloodstream infections in septic patients may be missed due to preceding antibiotic therapy prior to obtaining blood cultures. We leveraged the FABLED cohort study to determine if the quick Sequential Organ Failure Assessment (qSOFA) score could reliably identify patients at higher risk of bacteremia in patients who may have false negative blood cultures due to previously administered antibiotic therapy.
Methods: We conducted a multi-centre diagnostic study among adult patients with severe manifestations of sepsis.
Background: Sepsis is a leading cause of morbidity, mortality, and health care costs worldwide.
Methods: We conducted a multicenter, prospective cohort study evaluating the yield of blood cultures drawn before and after empiric antimicrobial administration among adults presenting to the emergency department with severe manifestations of sepsis. Enrolled patients who had the requisite blood cultures drawn were followed for 90 days.
Background: Patients with cirrhosis are at risk of developing cirrhotic cardiomyopathy. This syndrome is unique to cirrhosis and is generally defined as subnormal cardiac function in the absence of prior heart disease. There is no systematic or comprehensive review of cirrhotic cardiomyopathy to date.
View Article and Find Full Text PDFBackground And Aim: Primary sclerosing cholangitis (PSC), with or without inflammatory bowel disease (IBD), confers the risk of cholangiocarcinoma. Isolated IBD may be an independent risk factor for cholangiocarcinoma. We sought to compare cholangiocarcinoma phenotype and outcomes between patients with PSC, IBD, and neither.
View Article and Find Full Text PDFIschemic Colitis after Colonoscopy with Bisacodyl Bowel Preparation: A Report of Two Cases.
Case Rep Gastrointest Med
November 2020
Background: Colonoscopy is widely used for the diagnosis and management of colorectal disease and requires adequate bowel preparation. Ischemic colitis is a form of intestinal ischemia that presents with abdominal pain, diarrhea, and hematochezia. Risk factors include advanced age, cardiovascular disease, and diabetes.
View Article and Find Full Text PDFReal-world Time to Positivity of 2 Widely Used Commercial Blood Culture Systems in Patients With Severe Manifestations of Sepsis: An Analysis of the FABLED Study.
Open Forum Infect Dis
September 2020
Article Synopsis
- Blood cultures play a crucial role in managing patient care, especially for sepsis, but existing systems have not been directly compared in critically ill patients.
- This study analyzed the time to positivity (TTP) between two blood culture systems, BacT/Alert and BACTEC, in a cohort of 315 critical sepsis patients, with careful protocols to reduce biases.
- Results showed that BACTEC had a significantly faster TTP (12.5 hours) compared to BacT/Alert (17 hours), although there were no major differences in the bacterial species identified.
- The findings indicate that BACTEC could improve timely diagnosis, but further research is needed for unusual pathogens and clinical sensitivity.
Background: Administering antimicrobial agents before obtaining blood cultures could potentially decrease time to treatment and improve outcomes, but it is unclear how this strategy affects diagnostic sensitivity.
Objective: To determine the sensitivity of blood cultures obtained shortly after initiation of antimicrobial therapy in patients with severe manifestations of sepsis.
Design: Patient-level, single-group, diagnostic study.