Publications by authors named "Chris San Choon Kong"
Article Synopsis
- Thiopurines are commonly used for treating inflammatory bowel disease (IBD) but can cause significant variability in patient responses and side effects due to genetic differences.
- A study involving 149 multiethnic Asian IBD patients identified two FTO gene variants, revealing that one variant (rs16952570) showed differing prevalence among ethnic groups and was linked to better white blood cell counts in patients after starting thiopurine therapy.
- The research suggests that the FTO variant rs16952570 CC genotype may provide a protective effect on blood cell levels in patients undergoing thiopurine treatment, highlighting the importance of genetic testing in personalized medicine for IBD.
Background: Genetic variants of TPMT and NUDT15 have been reported to predict the inter-patient variability in response and toxicity profiles of patients receiving thiopurine therapy. However, the clinical utility of TPMT genotyping in guiding thiopurine doses has been questionable, in part due to underlying differences in the prevalence of TPMT variants in both Caucasian and Asian populations. Several NUDT15 variants have been associated with thiopurine-induced leukopenia, particularly in Asian cohorts.
View Article and Find Full Text PDFBackground And Aim: Brush cytology, the conventional method to diagnose cholangiocarcinoma, has been plagued by low diagnostic sensitivity and false-negative results. This paper aims to study the clinical utility of fluorescence in situ hybridization (FISH) in enhancing identification of malignant biliary strictures.
Methods: Brush cytologic specimens collected from endoscopic retrograde cholangiopancreatography for biliary strictures in a tertiary hospital in Singapore from March 2013 to July 2015 were examined by FISH technique using UroVysion probe set in this study.