Prototypical innate immune mechanism hijacked by leukemia-initiating mutant stem cells for selective advantage and immune evasion in Ptpn11-associated juvenile myelomonocytic leukemia.

Juvenile myelomonocytic leukemia (JMML), a clonal hematologic malignancy, originates from mutated hematopoietic stem cells (HSCs). The mechanism sustaining the persistence of mutant stem cells, leading to leukemia development, remains elusive. In this study, we conducted comprehensive examination of gene expression profiles, transcriptional factor regulons, and cell compositions/interactions throughout various stages of tumor cell development in Ptpn11 mutation-associated JMML.

The Growth of Problematic Media Use Over Early Childhood: Associations with Long-Term Social and Emotional Outcomes.

Problematic media use (PMU) tends to be related to significant social, emotional, and behavioral problems throughout life. Little research, however, has examined the development of PMU during early childhood, where media habits begin to form. The current longitudinal study examines the growth of PMU across early childhood (between 2.

Mothers' and fathers' depressive symptoms across four years postpartum: An examination of between- and bidirectional within-person relations.

Background: Both mothers and fathers are at risk for experiencing postpartum depressive symptoms shortly after the birth of a child. Previous studies suggest mothers' and fathers' depressive symptoms to be interrelated. This study examined bidirectional relations between mothers' and fathers' depressive symptoms across four years postpartum.

"Oh no! What happened?" an investigation of parent-child conversations about self-conscious emotions.

Parents play an important role in socializing children's emotion understanding. Previous research shows that parents emphasize different aspects of emotion contexts depending on the discrete emotion. However, there is limited research on how parents and children discuss self-conscious emotions, such as embarrassment, guilt, and shame, and what socialization practices parents employ to elicit children's talk about these emotions.

Links between parent-child conversations about emotions and changes in children's emotion knowledge across early childhood.

This study examined different sources of emotion socialization. Children (N = 256, 115 girls, 129 boys, 12 child gender not reported) and parents (62% White, 9% Black, 19% Hispanic, 3% Asian American, and 7% "Other") were recruited from Denver, Colorado. In waves 1 (M  = 2.

Parenting measurement, normativeness, and associations with child outcomes: Comparing evidence from four non-Western cultures.

This study compared parenting across four non-Western cultures to test cross-cultural commonality and specificity principles in three aspects: measurement properties, parenting normativeness, and their associations with child outcomes. Both mothers and fathers (N = 1509 dyads) with preschool-aged children (M = 5.00 years; 48% girls) from urban areas of four countries (Malaysia, N = 372; China, N = 441; Turkey, N = 402; and Japan, N = 294) reported on four parenting constructs (authoritative, authoritarian, group harmony socialization, and intrusive control) and their sub-dimensions using modified culturally relevant measures.

"Katerina gets mad": Infants' physiological and behavioral responses to co-viewing educational, self-regulatory media.

A growing body of research has focused on the physiological impact of media on older children and adolescents. Less research has been focused on the potential physiological impact of media on infants and younger children, especially media designed to be age appropriate and educational in content. In this study, we examined respiratory sinus arrhythmia (RSA) in infants (N = 269, M  = 17.

Development of mother-infant co-regulation: The role of infant vagal tone and temperament at 6, 9, and 12 months of age.

Using Porges' (2011) Polyvagal Theory as a backdrop, this study examined whether changes in parasympathetic functioning, as indexed by baseline measures of cardiac vagal tone at 6, 9, and 12 months of age, were linked to changes in infants' (N = 101) dyadic co-regulation over these same time points. Mothers and infants were observed at each time point during a 15-minute unstructured free-play and co-regulated patterns of interactions were coded using the Revised Relational Coding System (Fogel et al., 2003).

Attachment Issues: A Case Report of a Promising Sternal Implantation with 3D-printed Polyethylene.

Sternal reconstruction is beneficial for chest wall stability, respiratory function, and cosmetics, with no superior prosthesis or method thus far identified. We present a case of sternal reconstruction in a patient 6 years post sternal removal using a 3D-printed, patient-specific, polyethylene prosthesis with reasonable short-term outcomes. We believe a polyethylene prosthesis shows advantages over other materials and is worth further investigation, providing a technique for attaching said prosthesis to the native tissues is established.

Abdominal and perineal hernia rates following vertical rectus abdominis myocutaneous (VRAM) flap reconstruction - a supraregional experience.

Background: Vertical rectus abdominis myocutaneous (VRAM) flap has proven to be a robust reconstruction method following radical pelvic surgery. Radical pelvic surgery is associated with high morbidity due to pelvic complications and non-healing perineal wounds, as a result of non-collapsible pelvic dead space and pre-operative adjuvant radiotherapy insult. VRAM flap reconstruction addresses both issues by obliterating the dead space and introducing healthy non-radiated tissue.

Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles.

Lipophilic conjugates (LCs) of small molecule drugs have been used widely in clinical and pre-clinical studies to achieve a number of pharmacokinetic and therapeutic benefits. For example, lipophilic derivatives of drugs are employed in several long acting injectable products to provide sustained drug exposure for hormone replacement therapy and to treat conditions such as neuropsychiatric diseases. LCs can also be used to modulate drug metabolism, and to enhance drug permeation across membranes, either by increasing lipophilicity to enhance passive diffusion or by increasing protein-mediated active transport.

Associations between brain and behavioral processing of facial expressions of emotion and sensory reactivity in young children.

The ability to decode and accurately identify information from facial emotions may advantage young children socially. This capacity to decode emotional information may likewise be influenced by individual differences in children's temperament. This study investigated whether sensory reactivity and perceptual awareness, two dimensions of temperament, as well as children's ability to accurately label emotions relates to the neural processing of emotional content in faces.

Early life trauma: An exploratory study of effects on OXTR and NR3C1 gene expression and nurturing self-efficacy in mothers of infants.

Background: In animals, adverse early experience alters oxytocinergic and glucocorticoid activity and maternal behavior in adulthood. This preliminary study explored associations among childhood trauma (loss of a parent or sexual abuse in childhood), maternal self-efficacy, and leukocyte gene expression (mRNA) of oxytocin and glucocorticoid receptors (OXTR and NR3C1) in mothers of infants.

Methods: 62 mothers (20 with early life trauma) with healthy 3-month old infants reported maternal self-efficacy, depression, infant temperament, and overall social support; the effects of early trauma on these measures were assessed.

Behavioral and Neural Foundations of Multisensory Face-Voice Perception in Infancy.

In this article, we describe behavioral and neurophysiological evidence for infants' multimodal face-voice perception. We argue that the behavioral development of face-voice perception, like multimodal perception more broadly, is consistent with the intersensory redundancy hypothesis (IRH). Furthermore, we highlight that several recently observed features of the neural responses in infants converge with the behavioral predictions of the intersensory redundancy hypothesis.

Relational congruence facilitates neural mapping of spatial and temporal magnitudes in preverbal infants.

Mental representations of space, time, and number are fundamental to our understanding of the world around us. It should come as no surprise that representations of each are functional early in human development, appear to share a common format, and may be maintained by overlapping cortical structures. The consequences of these similarities for early learning and behavior are poorly understood.

Neural signatures of face-voice synchrony in 5-month-old human infants.

Infants' unitary perception of their multisensory world, including learning from people (faces and speech), hinges on temporal synchrony. Despite its importance, relatively little work has investigated the brain processes involved in infants' perception of temporal synchrony. In two experiments, we examined event-related brain potentials (ERPs) to asynchronous and synchronous audio-visual speech in infants.

Alcohol-related emergency department attendances: is preloading a risk factor? Cross-sectional survey.

Introduction: 'Preloading' is a phenomenon where people drink alcohol at a private residence before going out. We aimed to identify whether preloading is a risk factor for alcohol-related emergency department attendance. We also wanted to identify where people became injured or unwell.

Visual stimulation enhances auditory processing in 3-month-old infants and adults.

Behavioral work demonstrates human infants are sensitive to a host of intersensory properties and this sensitivity promotes early learning and memory. However, little is known regarding the neural basis of this ability in infants. Using event-related potentials (ERPs) with infants and adults, we show that during passive viewing auditory evoked brain responses are increased with the presence of simultaneous visual stimulation.

Racial differences in serum prostate-specific antigen (PSA) doubling time, histopathological variables and long-term PSA recurrence between African-American and white American men undergoing radical prostatectomy for clinically localized prostate cancer.

Objective: To determine if there are significant differences in biochemical characteristics, biopsy variables, histopathological data, and rates of prostate-specific antigen (PSA) recurrence between African-American (AA) and white American (WA) men undergoing radical prostatectomy (RP), as AA men are twice as likely to die from prostate cancer than their white counterparts.

Patients And Methods: We established a cohort of 1058 patients (402 AA, 646 WA) who had RP and were followed for PSA recurrence. Age, race, serum PSA, biopsy Gleason score, clinical stage, pathological stage, and PSA recurrence data were available for the cohort.

Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling.

Surface-enhanced laser desorption/ionization (SELDI) time-of-flight mass spectrometry with protein arrays has facilitated the discovery of disease-specific protein profiles in serum. Such results raise hopes that protein profiles may become a powerful diagnostic tool. To this end, reliable and reproducible protein profiles need to be generated from many samples, accurate mass peak heights are necessary, and the experimental variation of the profiles must be known.