Automated quality control in image segmentation: application to the UK Biobank cardiovascular magnetic resonance imaging study.

Background: The trend towards large-scale studies including population imaging poses new challenges in terms of quality control (QC). This is a particular issue when automatic processing tools such as image segmentation methods are employed to derive quantitative measures or biomarkers for further analyses. Manual inspection and visual QC of each segmentation result is not feasible at large scale.

Acute liver effects, disposition and metabolic fate of [C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.

The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed distribution into all tissues except the brain, with radioactivity still detectable in blood, kidney and liver at 72 h post-dose. Mice dosed with [C]-fenclozic acid showed acute centrilobular hepatocellular necrosis, but no other regions of the liver were affected.

Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder.

Objective: Hyperactivity, impulsiveness, and distractibility are common problems in children with autism spectrum disorder (ASD). Extended-release guanfacine is approved for children with attention deficit hyperactivity disorder but not well studied in ASD.

Method: In a multisite, randomized clinical trial, extended-release guanfacine was compared with placebo in children with ASD accompanied by hyperactivity, impulsiveness, and distractibility.

The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse.

1. The distribution, metabolism, excretion and hepatic effects of fenclozic acid were investigated following a single oral dose of 10 mg/kg to hepatic reductase null (HRN) mice. 2.

Diclofenac metabolism in the mouse: novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry.

The metabolism of [(14)C]-diclofenac in mice was investigated following a single oral dose of 10 mg/kg. The majority of the drug-related material was excreted in the urine within 24 h of administration (49.7 %).

The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: application to the metabolism of diclofenac.

The distribution, metabolism, excretion and hepatic effects of diclofenac were investigated following a single oral dose of 10 mg/kg to wild type and hepatic reductase null (HRN) mice. For the HRN strain the bulk of the [(14)C]-diclofenac-related material was excreted in the urine/aqueous cagewash within 12 h of administration (~82%) with only small amounts eliminated via the faeces (~2% in 24 h). Wild type mice excreted the radiolabel more slowly with ca.

Computational study on the origin of the stereoselectivity for the photochemical denitrogenation of diazabicycloheptene.

The origin of the inversion stereoselectivity of housane formation via photochemical nitrogen extrusion of diazabicycloheptene (DBH) has been investigated using reaction path computations and multireference second-order perturbation theory within a CASPT2//CASSCF scheme. We show that the primary photoproduct of the reaction is an exo-axial conformer of the diazenyl diradical ((1) DZ) which displays a cyclopenta-1,3-diyl moiety with a Cs-like structure. (1) DZ is selectively generated via decay at a linear-axial conical intersection, and it is located in a shallow region of the ground state potential energy surface that provides access to five different reaction pathways.