Intensive care due to myasthenia gravis: Risk factors and prognosis.

Background And Purpose: Exacerbation of myasthenia gravis (MG) with respiratory failure requires intensive care. We aimed to study the risk factors for intensive care unit admission for MG exacerbation and myasthenic crisis (MC) and the prognosis of people with MG (pwMG) thereafter.

Methods: This retrospective study investigated patients in the Helsinki and Uusimaa hospital district during the years 2008-2021.

A skewed ratio of free light chains is more common in patients with late-onset than early-onset myasthenia gravis.

Myasthenia gravis (MG) is an autoantibody-mediated neuromuscular disease with an unpredictable clinical course. Serum free light chains (FLCs) have risen as a promising biomarker for MG, but their role in different subtypes of MG and in predicting disease progression is still uncharted. We investigated plasma from 58 generalized MG patients during post-thymectomy follow-up to determine κ and λ FLC and κ/λ ratio.

Comorbidities worsen the prognosis of generalized myasthenia gravis post-thymectomy.

Background: The effect of comorbidities on the prognosis of myasthenia gravis (MG) remains unclear. In particular, the role of other autoimmune diseases (AD) is controversial.

Methods: In this retrospective single-center cohort study, we investigated 154 consecutive generalized thymectomized MG patients, with a mean follow-up time of 8.