Publications by authors named "Chris Moothart"
Article Synopsis
- The study investigates how the Wnt3a protein influences the Lef-1 transcription factor, which is crucial for the development of airway submucosal glands (SMGs) in mice.
- Researchers found that Wnt3a activates Lef-1 gene expression by associating with specific regions in the Lef-1 promoter, highlighting the role of beta-catenin and Tcf4 in this regulation.
- The findings confirm that Wnt3a not only initiates Lef-1 expression during the formation of SMG buds but is also essential for the continued growth of these glands, providing new insights into Wnt signaling pathways in developmental biology.
Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis.
Am J Physiol Lung Cell Mol Physiol
October 2004
Regulated expression of lymphoid enhancer factor 1 (Lef-1) plays an obligatory role in the transcriptional control of epithelial bud formation during airway submucosal gland and mammary gland development. However, regions of the Lef-1 promoter required for spatial and temporal regulation during glandular development have yet to be defined. We hypothesized that a previously reported 110-bp Wnt-responsive element (WRE) in the Lef-1 promoter, which can be induced by Wnt-3a/beta-catenin signals, may also play a role in regulating Lef-1 expression during airway and mammary gland development.
View Article and Find Full Text PDF