Non-prostate uptake on F-PSMA-1007 PET/CT: a case of myeloma.

Prostate-specific membrane antigen (PSMA), a glycoprotein that is highly expressed in prostate cancer, has been used as a target for molecular radiotherapy as well as imaging. Over the last couple of years, F-PSMA gained popularity due to its longer half-life (110 min) compared to gallium Ga-PSMA (68 min). This has helped the dissemination beyond large metropolitan centres.

Short-term effects of early initiation of magnesium infusion combined with cooling after hypoxia-ischemia in term piglets.

Background: Neuroprotection from therapeutic hypothermia (HT) is incomplete, therefore additional strategies are necessary to improve long-term outcomes. We assessed the neuroprotective efficacy of magnesium sulfate (MgSO) bolus and infusion over 48 h plus HT in a piglet model of term neonatal encephalopathy (NE).

Methods: Fifteen newborn piglets were randomized following hypoxia-ischemia (HI) to: (i) MgSO 180 mg/kg bolus and 8 mg/kg/h infusion with HT (Mg+HT) or (ii) HT and saline 0.

High-risk basal cell carcinoma excision in primary care: a retrospective observational study of compliance with NICE guidance.

Objectives: To assess compliance with 2010 National Institute for Health and Care Excellence (NICE) guidance on cancer services relating to the management of basal cell carcinomas (BCC) in the community, where except in specific circumstances it is recommended that only low-risk BCCs should be excised routinely.

Design And Setting: A retrospective observational study of the histopathology reports of BCC excisions received from primary care in two district general hospitals in the South of England. One hundred consecutive BCC excisions were analysed from each hospital.