Delayed-release rapamycin halts progression of left ventricular hypertrophy in subclinical feline hypertrophic cardiomyopathy: results of the RAPACAT trial.

Objective: Feline hypertrophic cardiomyopathy (HCM) remains a disease with little therapeutic advancement. Rapamycin modulates the mTOR pathway, preventing and reversing cardiac hypertrophy in rodent disease models. Its use in human renal allograft patients is associated with reduced cardiac wall thickness.

Setting an agenda to catalyze research in the social and organizational dimensions of Great Lakes remediation, restoration, and revitalization.

The Great Lakes region was once a hub of industry and innovation that provided wealth and identity to the region. Economic upheavals have left the region trying to recreate economies and cleanup degraded environments. There have been multiple, overlapping efforts to change these conditions and create a new narrative for the region through environmental remediation, habitat restoration, and community revitalization on the path towards resilience.

Case Report: Successful Reperfusion of Pulmonary Thromboembolism Using tPA in a Cat.

Pulmonary thromboembolism is a potentially life threatening condition that is uncommonly recognized in cats. Thrombolytic agents have been described as a treatment for this condition in human and canine patients, particularly in cases where hemodynamic instability is persistent despite supportive care. This report describes the clinical course, echocardiographic diagnosis, and successful thrombolysis of a cat with pulmonary thromboembolism.

Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity.

Twenty-two novel dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides (with IC values <200 µM) and fifteen novel insulinotropic peptides were identified in a boarfish protein hydrolysate generated at semi-pilot scale using Alcalase 2.4L and Flavourzyme 500L. This was achieved by bioassay-driven semi-preparative reverse phase-high performance liquid chromatography fractionation, liquid chromatography-mass spectrometry and confirmatory studies with synthetic peptides.

Zeolites ameliorate asbestos toxicity in a transgenic model of malignant mesothelioma.

Malignant mesothelioma (MM) is an almost invariably fatal cancer caused by asbestos exposure. The toxicity of asbestos fibers is related to their physicochemical properties and the generation of free radicals. We set up a pilot study to investigate the potential of the zeolite clinoptilolite to counteract the asbestos carcinogenesis by preventing the generation of reactive nitrogen and oxygen radicals.

Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice.

We recently reported that brain-specific human β-secretase 1 (BACE1) knock-in (PLB4), a mouse model of sporadic Alzheimer's disease (AD), also develops a severe diabetic phenotype characterised by impaired glucose homeostasis, decreased insulin sensitivity and a fatty liver phenotype. Hence, we here aimed to assess if targeted anti-diabetic therapies (Liraglutide and Fenretinide) would attenuate the diabetic and behavioural phenotype of these mice. PLB4 mice and wild-type (WT) controls were administered Liraglutide or Fenretinide for ten consecutive weeks alongside vehicle-treated mice.

Zeolite protects mice from iron-induced damage in a mouse model trial.

For centuries, zeolites have been used for their utility in binding metals, and they feature in a multitude of agricultural and industrial applications in which the honeycombed zeolite structures form ideal ion exchangers, catalysts and binding agents. Zeolites are currently in a transition period, moving towards implementation in human ailments and diseases. Here, we postulated that zeolites may be able to counter the effects of excess iron and conducted a mouse model trial to gauge the utility of this notion.

Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides.

Large quantities of low-value protein rich co-products, such as salmon skin and trimmings, are generated annually. These co-products can be upgraded to high-value functional ingredients. The aim of this study was to assess the antidiabetic potential of salmon skin gelatin and trimmings-derived protein hydrolysates in vitro.

Tumour Suppressor Genes Are Potential Plasma-Based Epigenetic Biomarkers for Malignant Pleural Mesothelioma.

Malignant pleural mesothelioma (MPM) is associated with asbestos exposure. Asbestos can induce chronic inflammation which in turn can lead to silencing of tumour suppressor genes. Wnt signaling pathway can be affected by chronic inflammation and is aberrantly activated in many cancers including colon and MPM.

An appraisal of management pathologies in the Great Lakes.

Recent research has produced broad application of the health concept to regional ecosystems, including the Great Lakes. The attention is warranted, as new and recurring stresses on the health of the Great Lakes undermine our understanding and hinder our ability to manage and restore critical ecological functions. There is widespread agreement that the Great Lakes are presently exhibiting symptoms of extreme stress and potentially irreversible and catastrophic damage.

The distribution of outcomes research papers across clinical journals.

This study examines the distribution of health outcomes research (HOR) studies in the clinical literature by clinical areas and journal impact factor. The authors reviewed 535 journals and divided the sample into higher and lower impact journals across four clinical area. Mann-Whitney and Kruskal-Wallis tests were used to examine differences across four categories of outcomes research articles published, specifically the incidence of articles in higher versus lower impact journals and differences across clinical areas.

Age-related changes in attentional tracking of multiple moving objects.

In a multiple-object tracking (MOT) task, young and older adults attentively tracked a subset of 10 identical, randomly moving disks for several seconds, and then tried to identify those disks that had comprised the subset. Young adults who habitually played video games performed significantly better than those who did not. Compared to young subjects (mean age = 20.

Recognition and position information in working memory for visual textures.

In three experiments, we examined connections between item-recognition memory and memory for item-position information. With sequences of compound gratings as study and probe items, subjects made either item-position judgments (Experiments 1 and 2), by identifying the serial position of the study item that matched the probe, or recognition judgments (Experiment 3), by judging whether the probe had or had not been presented in the study series. Integrating a summed-similarity account of recognition into a signal detection framework shows that the variance of summed similarities on lure trials (probe not present in the study series) exceeds the variance on target trials (probe present in the study series).

Fifteen years of aligning faculty development with primary care clinician-educator roles and academic advancement at the Medical College of Wisconsin.

Starting in 1991, the Medical College of Wisconsin's (MCW) primary care-focused faculty development programs have continuously evolved in order to sustain tight alignment among faculty members' needs, institutional priorities, and academic reward structures. Informed by literature on the essential competencies associated with academic success and using educational methods demonstrated to achieve targeted objectives, MCW's initial 1.5-day per month comprehensive faculty development programs prepared faculty as clinician-researchers, leaders, and educators.

Short-term visual recognition and temporal order memory are both well-preserved in aging.

Increased difficulty with memory for recent events is a well-documented consequence of normal aging, but not all aspects of memory are equally affected. To compare the impact of aging on short-term recognition and temporal order memory, young and older adults were asked to identify the serial position that a probe item had occupied in a study set, or to judge that the probe was novel (had not been in the study set). Stimuli were compound sinusoidal gratings, which resist verbal description and rehearsal.

Preservation of episodic visual recognition memory in aging.

Visual episodic recognition memory was assessed in young (mean age 22.5 years) and older (mean age 74.1 years) adults.