Publications by authors named "Chris Lappe"
Article Synopsis
- Clinical imaging techniques like PET combined with CT are becoming more common in biomedical research with small animals, but handling radioactive substances requires strict regulations and training to ensure safety.
- This paper outlines the requirements set by the Radiation Protection Act and associated regulations, with a focus on practical steps in PET/CT imaging, from receiving radiopharmaceuticals to waste disposal.
- An analysis of radiation doses over four years in a small animal imaging facility showed that personnel exposure is generally lower than in human PET/CT imaging, remaining well within legal limits.
Article Synopsis
- This study examined the connection between two imaging techniques, Quantitative Susceptibility Mapping (QSM) and Transcranial Sonography (TCS), to evaluate iron levels in the substantia nigra of patients with Parkinson's disease (PD).
- Eighteen imaging sessions were conducted on 15 PD patients, revealing strong correlations between nigral iron susceptibility and TCS measurements of echogenicity.
- The findings suggest that increased iron accumulation in the substantia nigra may contribute to the observed echogenicity in PD, with echogenicity likely reflecting stored ferritin-bound iron in microglia.
Background: Strong line of evidence suggests that the increased risk to develop AD may at least be partly mediated by cholesterol metabolism. A key regulator of cholesterol transport is the Apolipoprotein E4 (ApoE4), which plays a fundamental role in neuronal maintenance and repair. Impaired function of ApoE4 may contribute to altered cerebral metabolism leading to higher susceptibility to neurodegeneration.
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