Publications by authors named "Chris Kuhlberg"
Article Synopsis
- Up to 80% of SARS-CoV-2 infections are asymptomatic, but these individuals can still spread the virus, highlighting a need to understand why some people show symptoms while others do not.
- This study analyzed viral genetic variants and transcript variations in samples from both symptomatic and asymptomatic patients using advanced genomic techniques.
- Findings indicate that symptomatic infections have higher levels of specific viral RNA expressions and unique genetic deletions, suggesting a link between these factors and the severity of COVID-19, which could inform future treatment and vaccine strategies.
Extrachromosomal, circular DNA (ecDNA) is emerging as a prevalent yet less characterized oncogenic alteration in cancer genomes. We leverage ChIA-PET and ChIA-Drop chromatin interaction assays to characterize genome-wide ecDNA-mediated chromatin contacts that impact transcriptional programs in cancers. ecDNAs in glioblastoma patient-derived neurosphere and prostate cancer cell cultures are marked by widespread intra-ecDNA and genome-wide chromosomal interactions.
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