Cost-effectiveness of primary screening for CKD: a systematic review.

Background: Chronic kidney disease (CKD) is a major health problem with an increasing incidence worldwide. Data on the cost-effectiveness of CKD screening in the general population have been conflicting.

Study Design: Systematic review.

Biopsy sampling requirements for the estimation of muscle capillarization.

The aim of this study was to determine the number of tibialis anterior biopsy samples and muscle fibers required to estimate the capillary supply of individual muscle fibers (C:F(i)). C:F(i) was calculated for 25 type 1 fibers in each of 8 images from 3 biopsies of 5 young healthy individuals. Sequential estimation analysis indicated that 50 fibers from one biopsy are sufficient to characterize the C:F(i) of the tibialis anterior for a group of subjects.