Enhanced Reader Confidence and Differentiation of Calcification from Cerebral Microbleed Diagnosis Using QSM Relative to SWI.

Purpose: Accurate detection of cerebral microbleeds (CMBs) is important for detection of multiple conditions. However, CMBs can be challenging to identify on MR images, especially for distinguishing CMBs from the mimic of calcification. We performed a comparative reader study to assess the diagnostic performance of two primary MR sequences for differentiating CMBs from calcification.

Relationships Between Working From Home, Sitting Postures, and Low Back Pain During COVID-19: A Survey of Frequent Computer Users.

Objective: The aim of the study is to investigate the effects of working from home on musculoskeletal pain.

Methods: An e-survey of computer workers was conducted. Multinomial logistic regression modeling examined relationships between work location (work or home office desk, dining table, other), sitting posture (diagrams with descriptors), depressive symptoms (Center for Epidemiologic Studies Short Depression Scale), sleep quality (good/average vs poor) and pain (low back pain [LBP]), and other pain without LBP (asymptomatic).

HarmonyTM: multi-center data harmonization applied to distributed learning for Parkinson's disease classification.

Purpose: Distributed learning is widely used to comply with data-sharing regulations and access diverse datasets for training machine learning (ML) models. The traveling model (TM) is a distributed learning approach that sequentially trains with data from one center at a time, which is especially advantageous when dealing with limited local datasets. However, a critical concern emerges when centers utilize different scanners for data acquisition, which could potentially lead models to exploit these differences as shortcuts.

A machine learning-based prediction of hospital mortality in mechanically ventilated ICU patients.

Background: Mechanical ventilation (MV) is vital for critically ill ICU patients but carries significant mortality risks. This study aims to develop a predictive model to estimate hospital mortality among MV patients, utilizing comprehensive health data to assist ICU physicians with early-stage alerts.

Methods: We developed a Machine Learning (ML) framework to predict hospital mortality in ICU patients receiving MV.

A single-cell transcriptomic atlas of sensory-dependent gene expression in developing mouse visual cortex.

Sensory experience drives the refinement and maturation of neural circuits during postnatal brain development through molecular mechanisms that remain to be fully elucidated. One likely mechanism involves the sensory-dependent expression of genes that encode direct mediators of circuit remodeling within developing cells. However, while studies in adult systems have begun to uncover crucial roles for sensory-induced genes in modifying circuit connectivity, the gene programs induced by brain cells in response to sensory experience during development remain to be fully characterized.

Visual Functions Are Associated with Biomarker Changes in Alzheimer's Disease.

Background: While various biomarkers of Alzheimer's disease (AD) have been associated with general cognitive function, their association to visual-perceptive function across the AD spectrum warrant more attention due to its significant impact on quality of life. Thus, this study explores how AD biomarkers are associated with decline in this cognitive domain.

Objective: To explore associations between various fluid and imaging biomarkers and visual-based cognitive assessments in participants across the AD spectrum.

Evaluation of Two Videos that Apply Evidence-Based Strategies to Increase Self-Efficacy and Reduce Opioid-Related Stigma Among Medical Students.

Objective: This study evaluated the video-based application of evidence-based stigma reduction strategies to increase medical students' screening-diagnostic self-efficacy for opioid use disorder (OUD) and reduce stigma toward opioid use.

Methods: Formative qualitative research informed development of two videos for medical students. One uses an education strategy by including education regarding non-stigmatizing language use and OUD screening and diagnosis (Video A); the other uses an interpersonal contact strategy by presenting narratives regarding opioid use from three people who have a history of opioid use and three physicians (Video B).

The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ.

The exocyst protein complex is important for targeted vesicle fusion in a variety of cell types, however, its function in neurons is still not entirely known. We found that presynaptic knockdown (KD) of the exocyst component sec15 by transgenic RNAi expression caused a number of unexpected morphological and physiological defects in the synapse. These include the development of active zones (AZ) devoid of essential presynaptic proteins, an increase in the branching of the presynaptic arbor, the appearance of satellite boutons, and a decrease in the amplitude of stimulated postsynaptic currents as well as a decrease in the frequency of spontaneous synaptic vesicle release.

Emergent Criticality in Coupled Boolean Networks.

Early embryonic development involves forming all specialized cells from a fluid-like mass of identical stem cells. The differentiation process consists of a series of symmetry-breaking events, starting from a high-symmetry state (stem cells) to a low-symmetry state (specialized cells). This scenario closely resembles phase transitions in statistical mechanics.

Lithium-Ion Insertion Properties of Solution-Exfoliated Germanane.

The high theoretical energy density of alloyed lithium and germanium (LiGe), 1384 mAh/g, makes germanium a promising anode material for lithium-ion batteries. However, common alloy anode architectures suffer from long-term instability upon repetitive charge-discharge cycles that arise from stress-induced degradation upon lithiation (volume expansion >300%). Here, we explore the use of the two-dimensional nanosheet structure of germanane to mitigate stress from high volume expansion and present a facile method for producing stable single-to-multisheet dispersions of pure germanane.

Article Commentary: A Psychospiritual Integration frame of Reference for Occupational Therapy. Part 2: Transformative Occupations and the Change Process.

This paper builds upon the first in the series on psychospiritual integration (PSI) and examines the concept of transformative occupations and the process of change underpinning occupational therapy from a PSI perspective. A repertoire of new terms highlighting finer distinctions in the concept of occupation will be introduced and explained, as will the dynamic for transformation inherent in the psychospiritual integration change process. Suggestions for PSI-informed occupational therapy practice will be explored.

Effect of hydroxocobalamin on surface oximetry in nonexposed humans.

Introduction: The newer cyanide antidote, hydroxocobalamin, due to its pigmentation, has been found to cause interferences in some laboratory assays. Co-oximetry may also be affected by hydroxocobalamin, leading to false elevations in hemoglobin concentration, methemoglobin, carboxyhemoglobin, and false decreases in oxyhemoglobin. The Masimo Radical-7 is a medical device that performs noninvasive oximetry and estimates hemoglobin (Hb) concentration and percent carboxyhemoglobin (COHb), methemoglobin (MetHb), and oxyhemoglobin saturation (O2Hb).

Ordered mesoporous silicon through magnesium reduction of polymer templated silica thin films.

This paper describes the process of making ordered mesoporous silicon (Si) thin films. The process begins with mesoporous silica (SiO 2) thin films that are produced via evaporation induced self-assembly (EISA) using sol-gel silica precursors with a diblock copolymer template. This results in a film with a cubic lattice of 15 nm diameter pores and 10 nm thick walls.