Investigating wound healing characteristics of gingival and skin keratinocytes in organotypic cultures.

Objectives: The gingiva heals at an accelerated rate with reduced scarring when compared to skin. Potential well-studied factors include immune cell number, angiogenesis disparities and fibroblast gene expression. Differential keratinocyte gene expression, however, remains relatively understudied.

Programmes of measures of the marine strategy framework directive: Are they contributing to achieving good environmental status in the Mediterranean?

The Marine Strategy Framework Directive (MSFD) is the piece of legislation with which the EU aims to achieve Good Environmental Status (GES) of its seas. This Directive requires Member States (MSs) to set up and implement Programmes of Measures (PoMs) to achieve this goal. This paper presents a catalogue as well as the analysis of the 535 measures proposed by the eight Mediterranean EU MSs to combat pollution and non-indigenous species and contribute to the GES of the Mediterranean Sea.

Using socio-demographic and early clinical features in general practice to identify people with lung cancer earlier.

Introduction: In the UK, most people with lung cancer are diagnosed at a late stage when curative treatment is not possible. To aid earlier detection, the socio-demographic and early clinical features predictive of lung cancer need to be identified.

Methods: We studied 12,074 cases of lung cancer and 120,731 controls in a large general practice database.

The distribution of lung cancer across sectors of society in the United Kingdom: a study using national primary care data.

Background: There is pressing need to diagnose lung cancer earlier in the United Kingdom (UK) and it is likely that research using computerised general practice records will help this process. Linkage of these records to area-level geo-demographic classifications may also facilitate case ascertainment for public health programmes, however, there have as yet been no extensive studies of data validity for such purposes.

Methods: To first address the need for validation, we assessed the completeness and representativeness of lung cancer data from The Health Improvement Network (THIN) national primary care database by comparing incidence and survival between 2000 and 2009 with the UK National Cancer Registry and the National Lung Cancer Audit Database.

Test-retest reliability of a battery of field-based health-related fitness measures for adolescents.

The main aim of this study was to determine the test-retest reliability of existing tests of health-related fitness. Participants (mean age 14.8 years, s = 0.

A comprehensive analysis of adverse obstetric and pediatric complications in women with asthma.

Rationale: Previous studies have raised concern that women with asthma have increased risks of adverse obstetric and pediatric complications, but these have generally been underpowered.

Objectives: To quantify risks of major adverse pregnancy outcomes and obstetric complications in women with and without asthma.

Methods: We extracted information on 281,019 pregnancies from the Health Improvement Network database between 1988 and 2004.

Plant proteome analysis by mass spectrometry: principles, problems, pitfalls and recent developments.

The genome of several species has now been elucidated; these genomes indicate the proteomic potential of the cell. While identification of genomes has been, and continues to be, a technically and intellectually demanding process, the identification of the proteome contains inherently greater difficulties. The proteome of each living cell is dynamic, altering in response to the individual cell's metabolic state and reception of intracellular and extracellular signal molecules, and many of the proteins which are expressed will be post-translationally altered.

Malignancy and mortality in people with coeliac disease: population based cohort study.

Objective: To quantify the risks of malignancy and mortality in people with coeliac disease compared with the general population.

Design: Population based cohort study.

Setting: General practice research database.

Inhaled corticosteroids and hip fracture: a population-based case-control study.

There is accumulating evidence that the use of inhaled corticosteroids is associated with a dose-related reduction in bone mineral density. Whether this translates to an increase in fracture is unclear. We have used the General Practice Research Database to perform a case-control analysis, including 16,341 cases of hip fracture (mean age of 79 years, 79% female, median period prescribing data 2.