Publications by authors named "Chris J Kuckleburg"
Article Synopsis
- Previous research indicated that the apoptosis of bovine pulmonary artery endothelial cells caused by Haemophilus somnus lipooligosaccharide (LOS) relies on the activation of caspase-8.
- This study aimed to determine if TNF-alpha could enhance this apoptosis; however, while TNF-alpha alone did not induce or enhance apoptosis, blocking protein synthesis with cycloheximide significantly increased apoptosis when combined with TNF-alpha or LOS.
- Ultimately, the results suggest that LOS-induced apoptosis is partially mediated by a death pathway involving TNF-alpha receptor 1 (TNF-R1).
During sepsis, endothelial cells are both a source and target of pro-inflammatory cytokines (e.g. IL-1alpha, IL-1beta, TNFalpha and others), which may be detrimental to vascular homeostasis.
View Article and Find Full Text PDFExposure of endothelial cells to lipid A-containing molecules, such as lipopolysaccharide (LPS) or lipooligosaccharide (LOS), causes the release of purinergic compounds [e.g., adenosine 5'-triphosphate (ATP)] and can lead to apoptosis.
View Article and Find Full Text PDFVasculitis is commonly seen during systemic Haemophilus somnus infections. Although, the mechanism of vascular damage is not completely understood, in a previous report we demonstrated that H. somnus and its lipooligosaccharide (LOS) induced apoptosis in bovine pulmonary artery endothelial cells in vitro.
View Article and Find Full Text PDF