A randomized, double-blind comparison shows the addition of oxygenated glycerol triesters to topical mentholated cream for the treatment of acute musculoskeletal pain demonstrates incremental benefit over time.

Background: Topical analgesics are important products in the armamentarium for pain relief.

Methods And Findings: This study compared a topical analgesic product containing menthol to the same product with the addition of oxygenated glycerol triesters (OGTs) (also called essential oxygen oil) in 66 healthy adult subjects with acute musculoskeletal pain. Patients were randomized in a single-center, double-blind study to receive mentholated cream (MC) only or MC containing OGTs.

Preliminary observations of a novel topical oil with analgesic properties for treatment of acute and chronic pain syndromes.

Objective: Essential oxygen oil (OxyRub from CreoMed Inc., Naples, FL, U.S.