Finite element modelling and validation for breast cancer detection using digital image elasto-tomography.

Finite element (FE) models are increasingly used to validate experimental data in breast cancer. This research constructed a biomechanical FE model for breast shaped phantoms used to develop and validate a mechanical vibration based screening system. Such models do not currently exist but would enhance development of this screening technology.

Proof of concept non-invasive estimation of peripheral venous oxygen saturation.

Background: Pulse oximeters continuously monitor arterial oxygen saturation. Continuous monitoring of venous oxygen saturation (SvO) would enable real-time assessment of tissue oxygen extraction (OE) and perfusion changes leading to improved diagnosis of clinical conditions, such as sepsis.

Methods: This study presents the proof of concept of a novel pulse oximeter method that utilises the compliance difference between arteries and veins to induce artificial respiration-like modulations to the peripheral vasculature.

Blood Glucose Levels of Subelite Athletes During 6 Days of Free Living.

Background: Continuous glucose monitoring (CGM) devices, with their 1-5 min measurement interval, allow blood glucose (BG) concentration dynamics to be captured more frequently and less invasively than traditional BG measures. One cohort CGM could provide insight is athletes. This study investigates what impact their heightened energy expenditure and dietary intake may have on their ability to achieve optimal BG.

Modelling of the nonlinear end-systolic pressure-volume relation and volume-at-zero-pressure in porcine experiments.

The End-Systolic Pressure-Volume Relation (ESPVR) is generally modelled as a linear relationship between P and V as cardiac reflexes, such as the baroreflex, are typically suppressed in experiments. However, ESPVR has been observed to behave in a curvilinear fashion when cardiac reflexes are not suppressed, suggesting the curvilinear function may be more clinically appropriate. Data was gathered from 41 vena cava occlusion manoeuvres performed experimentally at a variety of PEEPs across 6 porcine specimens, and ESPVR determined for each pig.