Publications by authors named "Chris DelNagro"
Article Synopsis
- NAD is essential for many cellular processes, and GNE-618 is an NAMPT inhibitor that decreases NAD levels, leading to cell death in lab models.
- Cells with NAPRT1 can survive NAMPT inhibition by converting nicotinic acid to NAD, but this protection is only effective if the nicotinic acid is present before NAD is depleted.
- Tumor cells are particularly vulnerable to GNE-618 because they cannot produce NAD through de novo synthesis, and higher NAMPT levels correlate with greater sensitivity to the inhibitor, suggesting a potential method for identifying effective treatments.
