Publications by authors named "Chris Browne"

Article Synopsis
  • IRAK4 is a key player in IL-1R and TLR signaling, making it a target for treating autoimmune diseases.
  • Researchers developed KT-474, a powerful and selective IRAK4 degrader that can be taken orally, marking it as the first of its kind tested outside of cancer treatment.
  • KT-474 has completed phase I trials in healthy individuals and patients with skin conditions, and has advanced to phase II trials for further evaluation.
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Article Synopsis
  • * Researchers have developed KT-413, a novel dual-function molecule that effectively degrades IRAK4 and key transcription factors, Ikaros and Aiolos, to combat this subtype of lymphoma.
  • * KT-413 has shown promising results in preclinical studies, leading to the initiation of a phase 1 clinical trial targeting B-cell lymphomas, particularly those with MYD88 mutations.
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There is a growing debate amongst academics and practitioners on whether interventions made, thus far, towards Responsible AI have been enough to engage with the root causes of AI problems. Failure to effect meaningful changes in this system could see these initiatives not reach their potential and lead to the concept becoming another buzzword for companies to use in their marketing campaigns. Systems thinking is often touted as a methodology to manage and effect change; however, there is little practical advice available for decision-makers to include systems thinking insights to work towards Responsible AI.

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Advances in remote sensing and machine learning enable increasingly accurate, inexpensive, and timely estimation of poverty and malnutrition indicators to guide development and humanitarian agencies' programming. However, state of the art models often rely on proprietary data and/or deep or transfer learning methods whose underlying mechanics may be challenging to interpret. We demonstrate how interpretable random forest models can produce estimates of a set of (potentially correlated) malnutrition and poverty prevalence measures using free, open access, regularly updated, georeferenced data.

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The design of adaptation strategies that promote urban health and well-being in the face of climate change requires an understanding of the feedback interactions that take place between the dynamical state of a city, the health of its people, and the state of the planet. Complexity, contingency and uncertainty combine to impede the growth of such systemic understandings. In this paper we suggest that the collaborative development of conceptual models can help a group to identify potential leverage points for effective adaptation.

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Background: Mobile learning (ML) is an emerging educational method with success dependent on many factors including the ML device, physical infrastructure and user characteristics. At Gippsland Medical School (GMS), students are given a laptop at the commencement of their four-year degree. We evaluated the educational impact of the ML program from students' perspectives.

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Maize genetic diversity has been used to understand the molecular basis of phenotypic variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred maize lines to the B73 reference line, capturing a total of 136,000 recombination events. Variation for recombination frequencies was observed among families, influenced by local (cis) genetic variation.

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Flowering time is a complex trait that controls adaptation of plants to their local environment in the outcrossing species Zea mays (maize). We dissected variation for flowering time with a set of 5000 recombinant inbred lines (maize Nested Association Mapping population, NAM). Nearly a million plants were assayed in eight environments but showed no evidence for any single large-effect quantitative trait loci (QTLs).

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This paper synthesises three diverse approaches to the study of consciousness in a description of an existing program of work in Artificial Neuroconsciousness. The three approaches are drawn from automata theory ([Aleksander, 1995][Aleksander, 1996]), psychology ([Karmiloff-Smith, 1992]; [Clark Karmiloff-Smith, 1993]) and philosophy ([Searle, 1992]).Previous work on bottom-level sensory-motor tasks from the program is described as a background to the current work on generating higher-level, abstract concepts which are an essential part of mental life.

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