Evaluation of Implant Stability Quotient of Sandblasted Acid-Etched (SAE) and Chemical-Modified SAE Dental Implants: A Clinical Study.

Objectives: The goal of the current research was to assess the implant stability quotient (ISQ) of dental implants that were chemically changed with SAE and without SAE.

Materials And Methods: Patients in the current study had dental implants fitted with SAE (Group I) and chemically altered SAE (Group II). After implant implantation, resonance frequency analysis (RFA) was performed as soon as possible as well as one, three, six, nine, and twelve weeks later.

Development of a natural language processing algorithm for the detection of spinal metastasis based on magnetic resonance imaging reports.

Background: Metastasis to the spinal column is a common complication of malignancy, potentially causing pain and neurologic injury. An automated system to identify and refer patients with spinal metastases can help overcome barriers to timely treatment. We describe the training, optimization and validation of a natural language processing algorithm to identify the presence of vertebral metastasis and metastatic epidural cord compression (MECC) from radiology reports of spinal MRIs.

Estimation of Loss of Crestal Bone Around Dental Implants in Various Tissue Biotypes Using CBCT.

Objectives: To evaluate the loss of crestal bone height around dental implants placed in various tissue biotypes.

Materials And Methods: 20 patients with single edentulous sites were allocated randomly, with 10 samples in each into Group I (implants were placed in thick tissue biotype) and Group II (implants were placed in thin tissue biotype). Baseline cone-beam computed tomography (CBCT) was performed after implant placement in both groups, and follow-up CBCT was taken at the time of cementation prior to occlusal loading to assess the crestal bone loss around the mesial and distal side of implants in both groups.

Epigenetic regulation during meiosis and crossover.

Meiosis is a distinctive type of cell division that reorganizes genetic material between generations. The initial stages of meiosis consist of several crucial steps which include double strand break, homologous chromosome pairing, break repair and crossover. Crossover frequency varies depending on the position on the chromosome, higher at euchromatin region and rare at heterochromatin, centromeres, telomeres and ribosomal DNA.

A Comparative Study on the Shaping Ability and Cleaning Efficiency of Two Different Single-File Systems, Reciprocating Wave One Versus Continuous Rotation F360, Evaluated by Scanning Electron Microscope: An In Vitro Study.

Background In endodontics, the three processes of biomechanical preparation, disinfection, and obturation are each essential. The electron microprobe and scanning electron microscope (SEM) allowed for the detection and identification of the smear layer and debris. The purpose of the current investigation was to use a scanning electron microscope to evaluate the relative merits of two single-file systems, the reciprocating WaveOne and the continuous motion F360 files, in the cleaning and contouring of root canals in removed teeth.

SHP-1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription.

Dynamic regulation of phosphorylation and dephosphorylation of histones is essential for eukaryotic transcription, but the enzymes engaged in histone dephosphorylation are not fully explored. Here, we show that the tyrosine phosphatase SHP-1 dephosphorylates histone H2B and plays a critical role during transition from the initiation to the elongation stage of transcription. Nuclear-localized SHP-1 is associated with the Paf1 complex at chromatin and dephosphorylates H2B at tyrosine 121.

Effect of nonthermal atmospheric plasma on the shear bond strength of composite resin after using different tooth-whitening systems: An study.

Aim: We aimed to evaluate the effect of nonthermal atmospheric plasma (NTAP) on the bond strength of composite resin after using different tooth-whitening systems.

Methods: Eighty maxillary central incisors ( = 80) were divided into two groups based on the tooth-whitening procedure used - Group 1: bleaching (Pola Office, USA), Group 2: microabrasion (Opalustre, Australia). The samples were subdivided into four groups depending on the surface treatments - Group A: control (no surface treatment), Group B: plasma, Group C: antioxidant (sodium ascorbate), and Group D: buffering agent (sodium bicarbonate).

Reproductive Outcomes after Laparoscopic Myomectomy: Conventional versus Barbed Suture.

Study Objective: To study the reproductive outcomes after laparoscopic myomectomy comparing conventional (nonbarbed) suture with barbed suture used for myometrial defect closure.

Design: Monocentric retrospective cohort study with prospective follow-up survey for reproductive outcomes conducted in April and May 2020.

Setting: Tertiary care center (center for advanced gynecologic laparoscopy and infertility).

An evaluation of biodegradability of stainless steel crowns at various salivary pH.

Aim: To evaluate the biodegradability of preformed stainless steel crowns at varying salivary pH and the cytotoxic effect of leached out elements on fibroblasts.

Methodology: A total of 243 stainless steel crowns were selected and were divided into 3 groups (I, II, III) based on Ph of immersion media. The pH of samples in group I, II, III were 4.

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

Tyrosine phosphatases play a critical role in many cellular processes and pathogenesis, yet comprehensive analysis of their functional interacting proteins in the cell is limited. By utilizing a proteomic approach, here we present an interaction network of 81 human tyrosine phosphatases built on 1884 high-confidence interactions of which 85% are unreported. Our analysis has linked several phosphatases with new cellular processes and unveiled protein interactions genetically linked to various human diseases including cancer.

Fatal swine influenza A H1N1 and Mycoplasma pneumoniae coinfection in a child.

One of the most common causes of death in influenza patients is secondary bacterial pneumonia and the most common pathogens involved are Streptococcus pneumoniae, Staphylococcus aureus, and Haemophilus influenza. To diagnose co infection with bacteria in a H1N1 case can be difficult but should be strongly suspected in a child who present with influenza like illness and lower respiratory tract signs or symptoms. We report coinfection of Mycoplasma pneumoniae in swine influenza A H1N1 child who presented with extensive pneumonia and expired within 48 hours.

Ethanolic extracts of Alstonia Scholaris and Bacopa Monniera possess neuroleptic activity due to anti-dopaminergic effect.

Background: An increased inclination has been observed for the use of herbal drugs in chronic and incurable diseases. Treatment of psychiatric diseases like schizophrenia is largely palliative and more importantly, a prominent adverse effect prevails with the majority of anti-psychotic drugs, which are the extrapyramidal motor disorders. Existing anti-psychotic drug therapy is not so promising, and their adverse effect is a matter of concern for continuing the therapy for long duration.

In vitro Dissolution Studies on Solid Dispersions of Mefenamic Acid.

Solid dispersions of mefanamic acid with a water-soluble polymer polyvinyl pyrrolidine and a super disintegrant, primojel were prepared by common solvent and solvent evaporation methods employing methanol as the solvent. The dissolution rate and dissolution efficiency of the prepared solid dispersions were evaluated in comparison to the corresponding pure drug. Solid dispersions of mefenamic acid showed a marked enhancement in dissolution rate and dissolution efficiency.

Parenteral nutrition: Revisited.

The prevalence of malnutrition among critically ill patients, especially those with a protracted clinical course, has remained largely unchanged over the last two decades. The metabolic response to stress, injury, surgery, or inflammation cannot be accurately predicted and these metabolic alterations may change during the course of illness. Both underfeeding and overfeeding are common in intensive care units (ICU), resulting in large energy and other nutritional imbalances.

Formulation and characterization of rifampicin microcapsules.

Rifampicin biodegradable microcapsules were prepared by feasible emulsification-ionic gelation method for a novel controlled release product. Sodium alginate and Carbopol 974P were used as coating polymers in different ratios 1:1, 1:2, 1:3 and 1:4 to obtain elegant microcapsules. The formulations were characterized for encapsulation efficiency, drug loading, sieve analysis, scanning electron microscopy and in vitro release studies.

Epinephrine test dose in children: is it interpretable on ECG monitor?

Background: Epidural and other regional blocks are performed in children under general anesthesia; the response to a 'test dose' may be altered during administration of general anesthetics. Limited data is available describing changes in electrocardiogram, blood pressure and heart rate (HR) following unintentional intravascular injection of a lidocaine-epinephrine-containing test dose, under sevoflurane anesthesia in children.

Methods: Sixty-eight children undergoing elective surgeries under sevoflurane anesthesia were administered 0.

Influence of hydroxypropyl methylcellulose on drug release pattern of a gastroretentive floating drug delivery system using a 3(2) full factorial design.

In the present investigation, controlled release gastroretentive floating drug delivery system of theophylline was developed employing response surface methodology. A 3(2) randomized full factorial design was developed to study the effect of formulation variables like various viscosity grades and contents of hydroxypropyl methylcellulose (HPMC) and their interactions on response variables. The floating lag time for all nine experimental trial batches were less than 2 min and floatation time of more than 12 h.

Uncemented metal-on-metal acetabular component: follow-up of 112 hips for a minimum of 5 years.

Background: Aseptic loosening is the major cause of implant failure. In cemented hip arthroplasty, failure of the acetabular side is mainly due to lysis caused by wear particles. By using an implant with low wear characteristics and by enhancing acetabular fixation using an uncemented implant, we aimed to reduce acetabular lysis and thereby loosening.

Ketamine is effective in decreasing the incidence of emergence agitation in children undergoing dental repair under sevoflurane general anesthesia.

Background: Emergence agitation or delirium is a known phenomenon that may occur in children undergoing general anesthesia with inhaled agents. Our aim was to test the hypothesis that the addition of a small dose of ketamine at the end of sevoflurane anesthesia will result in a decrease in the incidence and severity of such phenomenon.

Methods: We performed a randomized double blind study involving 85 premedicated children 4-7 years old undergoing dental repair.

Tablet formulation studies on nimesulide and meloxicam-cyclodextrin binary systems.

The objective of this work was to develop tablet formulations of nimesulide-beta-cyclodextrin (NI-beta-CD) and meloxicam-gamma-cyclodextrin (ME-gamma-CD) binary systems. In the case of nimesulide, 3 types of binary systems--physical mixtures, kneaded systems, and coevaporated systems--were studied. In the case of meloxicam, 2 types of binary systems--physical mixtures and kneaded systems--were investigated.

Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl beta-cyclodextrin.

Complexation of celecoxib with hydroxypropyl beta-cyclodextrin (HPbetaCD) in the presence and absence of 3 hydrophilic polymers-polyvinyl pyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG)-was investigated with an objective of evaluating the effect of hydrophilic polymers on the complexation and solubilizing efficiencies of HPbetaCD and on the dissolution rate of celecoxib from the HPbetaCD complexes. The phase solubility studies indicated the formation of celecoxib-HPbetaCD inclusion complexes at a 1:1M ratio in solution in both the presence and the absence of hydrophilic polymers. The complexes formed were quite stable.

Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl β-cyclodextrin.

Complexation of celecoxib with hydroxypropyl β-cyclodextrin (HPβCD) in the presence and absence of 3 hydrophilic polymers-polyvinyl pyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG)-was investigated with an objective of evaluating the effect of hydrophilic polymers on the complexation and solubilizing efficiencies of HPβCD and on the dissolution rate of celecoxib from the HPβCD complexes. The phase solubility studies indicated the formation of celecoxib-HPβCD inclusion complexes at a 1∶1M ratio in solution in both the presence and the absence of hydrophilic polymers. The complexes formed were quite stable.

Mucoadhesive microspheres for controlled drug delivery.

Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesive micro-spheres exhibit a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved and/or better therapeutic performance of drugs. In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects.

Cardioprotective activity of Hydrocotyle asiatica L. in ischemia-reperfusion induced myocardial infarction in rats.

The alcoholic extract of Hydrocotyle asiatica Linn. (Hydrocotyle asiatica L.) whole plant was evaluated for cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.