Banking Mesenchymal Stromal Cells from Umbilical Cord Tissue: Large Sample Size Analysis Reveals Consistency Between Donors.

Mesenchymal stromal cells (MSCs) have emerged as candidate cells with therapeutic potential to treat different pathologies. The underlying mechanism is paracrine signaling. The cells secrete proteins that can impact inflammation, apoptosis, angiogenesis, and cell proliferation.

Attention-Deficit Hyperactivity Disorder Risk: Interaction Between Parental Age and Maternal History of Attention-Deficit Hyperactivity Disorder.

Objective: To assess the interaction between maternal attention-deficit/hyperactivity disorder (ADHD) history and young parental age on child's ADHD risk.

Methods: The study included 321,272 singleton children born between 1995 and 2012 from hospitals within a single integrated health care organization. The children were prospectively followed up through electronic medical record systems from birth until the first date of the following: date of clinical diagnosis of ADHD, last date of continuous health plan membership, death due to any cause, or December 31, 2017.

Hemoglobin A1c Levels During Pregnancy and Risk of Autism Spectrum Disorders in Offspring.

This cohort study uses electronic medical record (EMR) data to examine the association between maternal hemoglobin A levels during pregnancy and risk of autism spectrum disorder in offspring.

High-Performance Organic Dyes with Electron-Deficient Quinoxalinoid Heterocycles for Dye-Sensitized Solar Cells under One Sun and Indoor Light.

A series of Y-shaped sensitizers incorporating quinoxaline or quinoxalinoid moieties were prepared and applied in dye-sensitized solar cells (DSSCs). By the introduction of quinoxalinoid functionalities, the absorption extinction coefficients could be enhanced. The molecular structures were modified by introducing an extra acceptor group (A) between a donor (D) and a π-bridge (D-A-π-A) and also by incorporating electron-donating substituents at various positions of the quinoxalinoid moiety.

Health-related quality of life in pregnancy with uterine fibroid: a cross-sectional study in China.

Background: Uterine fibroids (UFs) are the most common benign tumors in women. They are likely to cause numerous clinical symptoms, such as pain, menorrhagia, and other obstetric complications in pregnant women. This study aimed to determine the health-related quality of life (HRQoL) during pregnancy with uterine fibroids (UF), thus providing a utility-based case value in pregnant women with UF and understanding of whether HRQoL is associated with clinical outcomes in pregnant women with UFs.

Coping with my own way: Mediating roles of emotional expression and social support seeking in the associations between individual differences and posttraumatic growth.

This study examined the associations between individual differences and posttraumatic growth, and coping strategies as mediators among 454 trauma-exposed American college students. Results showed that relational-interdependent self-construal, optimism, emotional expression, and social support seeking were associated with higher posttraumatic growth. Moreover, social support seeking and emotional expression partially mediated between relational-interdependent self-construal and posttraumatic growth, such that relational-interdependent self-construal was associated with posttraumatic growth through increased support seeking and emotional expression.

Switching plasmonic Fano resonance in gold nanosphere-nanoplate heterodimers.

The interference between spectrally overlapping superradiant and subradiant plasmon resonances generates plasmonic Fano resonance, which allows for attractive applications such as electromagnetically induced transparency, light trapping, and refractometric sensing with high figures of merit. The active switching of plasmonic Fano resonance holds great promise in modulating optical signals, dynamically harvesting light energy, and constructing switchable plasmonic sensors. However, structures enabling the active control of plasmonic Fano resonance have rarely been achieved because of the fabrication complexity and cost.

Anodal Transcranial Direct Current Stimulation to the Left Rostrolateral Prefrontal Cortex Selectively Improves Source Memory Retrieval.

Functional neuroimaging studies have consistently implicated the left rostrolateral prefrontal cortex (RLPFC) as playing a crucial role in the cognitive operations supporting episodic memory and analogical reasoning. However, the degree to which the left RLPFC causally contributes to these processes remains underspecified. We aimed to assess whether targeted anodal stimulation-thought to boost cortical excitability-of the left RLPFC with transcranial direct current stimulation (tDCS) would lead to augmentation of episodic memory retrieval and analogical reasoning task performance in comparison to cathodal stimulation or sham stimulation.

Exactly Robust Kernel Principal Component Analysis.

Robust principal component analysis (RPCA) can recover low-rank matrices when they are corrupted by sparse noises. In practice, many matrices are, however, of high rank and, hence, cannot be recovered by RPCA. We propose a novel method called robust kernel principal component analysis (RKPCA) to decompose a partially corrupted matrix as a sparse matrix plus a high- or full-rank matrix with low latent dimensionality.

Total vs hemithyroidectomy for intermediate risk papillary thyroid cancer: A 23 year retrospective study in a tertiary center.

Background: There is much debate in the literature over the extent of surgery for patients with intermediate risk papillary thyroid cancer. We herein report our results in a local tertiary hospital.

Method: We identify from our database patients with papillary thyroid cancer who underwent surgery in our hospital and were stratified to be of intermediate risk from the GAMES stratification system.

Breastfeeding Persistence at 6 Months: Trends and Disparities from 2008 to 2015.

Objective: To assess trends and disparities in breastfeeding by maternal characteristics (race and ethnicity, age at delivery, obesity, parity, and level of education) and the relative importance among these for breastfeeding at 6 months.

Study Design: This retrospective birth cohort study included 195 861 live singleton children born at 32-42 weeks of gestation from 2008 to 2015 within a single integrated healthcare system. All children had healthcare coverage during the first year of life.

Bridging User Interest to Item Content for Recommender Systems: An Optimization Model.

Recommender systems are currently utilized widely in e-commerce for product recommendations and within content delivery platforms. Previous studies usually use independent features to represent item content. As a result, the relationship hidden among the content features is overlooked.

The Kinetochore-Microtubule Coupling Machinery Is Repurposed in Sensory Nervous System Morphogenesis.

Dynamic coupling of microtubule ends to kinetochores, built on the centromeres of chromosomes, directs chromosome segregation during cell division. Here, we report that the evolutionarily ancient kinetochore-microtubule coupling machine, the KMN (Knl1/Mis12/Ndc80-complex) network, plays a critical role in neuronal morphogenesis. We show that the KMN network concentrates in microtubule-rich dendrites of developing sensory neurons that collectively extend in a multicellular morphogenetic event that occurs during C.

Evaluation of the predictive performance of physiologically based pharmacokinetic models for intramuscular injections of therapeutic proteins.

Several physiologically-based pharmacokinetic (PBPK) models have been reported for intravenous (IV) and subcutaneous (SC) injections, but there has been a paucity of work for intramuscular (IM) injections. The primary objective of this work was a wide-scale evaluation of the predictive performance of IM PBPK models of therapeutic proteins. PBPK models for all administration routes available in the literature have regarded muscle as the total muscle (TM) in the body; however, anatomically, the body is composed of discrete muscle groups.

Functional characterization of two variants in the 3'-untranslated region (UTR) of transcription factor 4 gene and their association with schizophrenia in sib-pairs from multiplex families.

Transcription factor 4 (TCF4) gene plays an important role in nervous system development and it always associated with the risk of schizophrenia. Since miRNAs regulate targetgenes by binding to 3'UTRs of target mRNAs, the functional variants located in 3'UTR of TCF4 are highly suggested to affect the gene expressions in schizophrenia. To test the hypothesis regarding the effects of the variants located in 3'UTR of TCF4, we conducted an in silico analysis to identify the functional variants and their predicted functions.

Decellularizing and Recellularizing Adult Mouse Kidneys.

Decellularization is the process by which resident cells are lysed and cellular debris is removed from the tissue, leaving behind the extracellular matrix scaffold. The extracellular matrix scaffold can be used for three-dimensional culturing of cells. Here we describe methods of decellularizing whole and thick sections of mouse kidneys using a 0.

Postnatal outcomes in lambs exposed antenatally and acutely postnatally to fluoxetine.

Background: Approximately 1/3 of newborns exposed antenatally to selective serotonin reuptake inhibitors (SSRIs) exhibit poor neonatal adaptation. Although several potential mechanisms have been proposed, the actual mechanism has not been elucidated.

Methods: We investigated outcomes in neonatal lambs exposed prenatally or postnatally to fluoxetine (FX).

Patient-reported outcome measures (PROMs) and maintenance events in 2-implant-supported mandibular overdenture patients: A 5-year prospective study.

Objective: To prospectively evaluate patient-reported outcome measures (PROMs) and treatment outcomes of mandibular two-implant retained overdentures (IOD) in an edentulous geriatric cohort with history of deficient complete dentures (CD).

Materials And Methods: A total of 103 patients with deficient CD received new optimal CD. After a period of 3 months, 80 of the patients voluntarily received IOD.

An evaluation of the ontogeny of stereoselective fluoxetine metabolism and disposition in lambs from birth to one year of age.

1. The objective was to determine the ontogeny of stereoselective fluoxetine (FX) disposition in postnatal sheep from newborn to adulthood. 2.

Fatal spontaneous rupture of splenic artery aneurysm in third trimester pregnancy.

Introduction: Unforeseen emergency in late pregnancy can be catastrophic and cause unexpected maternal and foetal demise. Moreover, lack of awareness and failure of prompt treatment raise mortality rate. Such fatalities warrant a forensic autopsy as it may raise redundant medico-legal concerns.

Topic-Based Algorithm for Multilabel Learning With Missing Labels.

In multilabel learning (MLL), each instance can be assigned by several concepts simultaneously from a class dictionary. Usually, labels in the class dictionary have semantic correlations and semantic hierarchy. Instances can be categorized into different topics.

BrainWorks: A Comparative Effectiveness Trial to Examine Alzheimer's Disease Education for Community-Dwelling African Americans.

Objectives: To test a culturally tailored intervention to improve Alzheimer's disease (AD) literacy among African Americans.

Design: A 3-arm randomized comparative effectiveness trial.

Setting: Community sites in Los Angeles, CA.

Fundamental causes of barriers to participation in Alzheimer's clinical research among African Americans.

African Americans have a significantly higher risk than Whites for developing Alzheimer's disease (AD), but show lower participation in AD clinical trials. Studies of African Americans' involvement in clinical research have identified fear and mistrust of research as barriers to participation. Historical occurrences of unethical research practices are often cited as the source of these attitudes, but underlying factors such as African Americans' experiences of racism and discrimination remain unexplored.

Impact of Gastric Banding Versus Metformin on β-Cell Function in Adults With Impaired Glucose Tolerance or Mild Type 2 Diabetes.

Objective: Type 2 diabetes (T2D) results from progressive loss of β-cell function. The BetaFat study compared gastric banding and metformin for their impact on β-cell function in adults with moderate obesity and impaired glucose tolerance (IGT) or recently diagnosed, mild T2D.

Research Design And Methods: Eighty-eight people aged 21-65 years, BMI 30-40 kg/m, with IGT or diabetes known for <1 year, were randomized to gastric banding or metformin for 2 years.

Gelsemium poisoning mediated by the non-toxic plant Cassytha filiformis parasitizing Gelsemium elegans.

Introduction: Gelsemium poisoning is caused by consumption of the deadly Gelsemium species such as Gelsemium elegans, leading to significant gastrointestinal, neurological and cardio-respiratory toxicities. In 2011 (Cluster 1) and 2012 (Cluster 2), the authors encountered two clusters of gelsemium poisoning after consumption of the non-toxic parasitic plant Cassytha filiformis. The current study aims to examine the mechanism of gelsemium poisoning mediated by a benign parasitic plant.