Effect of the enhanced recovery after surgery protocol in patients undergoing elective craniotomies: a systematic review and meta-analysis.

Enhanced recovery after surgery protocol (ERASP) improves postoperative outcomes. However, its implementation in neurosurgery remains under explored, resulting in the absence of standard evidence-based guidelines. Thus, we compared the outcomes of ERASP and conventional perioperative care (CPC) in patients undergoing elective craniotomy for various intracranial pathologies.

Zinc sensing by a Janus-faced fluorophore and its application in the cellular microenvironment.

In this work, we have investigated the metal sensing capabilities of dimeric fused heterocycles, PQ-BCN and PQN-BCN, bearing a pyrrole-pyridine chelating unit. PQ-BCN displayed selectivity towards Zn2+ in micromolar levels by steady-state absorbance and fluorescence-assisted screening experiments. The binding stoichiometry of the complex was determined to be a 2:1 metal-to-probe ratio, with an association constant (Ka) of 1.

Evaluation of the Antibacterial and Antifungal Efficacy of Chitosan Nanoparticles in Irreversible Hydrocolloid Impression Materials: A Cross-Sectional Study.

Introduction: Irreversible hydrocolloid (IHC) impression materials are widely used in dentistry for diagnostic impressions; however, they pose a risk of cross-contamination. Current cleaning methods such as rinsing with water may not be sufficient for effective disinfection. Incorporation of antimicrobial agents into IHC materials can reduce this risk.

Feasibility of the 3D printer to design an intracavitary applicator for the treatment of cervical cancer patients with high dose rate brachytherapy system.

Designing an intracavitary brachytherapy applicator with a 3D printer using Polyamide12 for Tandem-Ovoid configuration. Further, to evaluate its feasibility and initial clinical use for the treatment of cervical cancer patients with a High Dose Rate (HDR) brachytherapy system. SolidWorks, Computer Aided design software was used for the design of the intracavitary brachytherapy applicator.

Early neurobehavioral outcome in preterm small for gestational age neonates with increased pulsatility index in antenatal umbilical artery Doppler.

To evaluate the early neurobehavioral outcome in preterm small for gestational age neonates with increased pulsatility index in antenatal umbilical artery Doppler. A prospective cohort study was conducted at a tertiary care neonatal unit in India. 30 preterm SGA neonates born to mothers with increased pulsatility index (> 95th centile) were enrolled and compared with 30 SGA neonates with normal pulsatility index (<95th centile).

Impact of Soft Liners on Bite Force in Complete Denture Wearers: A Prospective Cohort Study.

Introduction: Edentulism is a significant global oral health concern, particularly among elderly individuals. Complete dentures are widely used to restore oral functionality, esthetics, and quality of life. The incorporation of soft liners into complete dentures has been proposed as a means of improving patient comfort and reducing the pressure on the oral mucosa.

Transition Metal-Based Perovskite Derivatives for Selective CO Photoreduction: Role of Orbital Occupancy.

Transition metals are renowned for their effective catalytic properties. Incorporating transition metals into halide perovskite derivatives is a key strategy for tuning the properties of perovskites to enhance their photocatalytic performance. Understanding the d-orbital occupancy and spin activity of these transition metals in the CO photoreduction process is essential for fully realizing the photocatalytic potential of these materials.

Designing smartphone-based cognitive assessments for schizophrenia: Perspectives from a multisite study.

Introduction: Cognitive deficits represent a core symptom of schizophrenia and a principal contributor to illness disability, yet evaluating cognition in routine clinical settings is often not feasible as cognitive assessments take longer than a standard doctor's visit. Using smartphones to assess cognition in schizophrenia offers the advantages of convenience in that patients can complete assessments outside of the clinic, temporality in that longitudinal trends can be identified, and contextuality in that cognitive scores can be interpreted with other measures captured by the phone (e.g.

A robust fluorogenic substrate for chikungunya virus protease (nsP2) activity.

Chikungunya virus (CHIKV) is an emerging pathogen with pandemic potential. CHIKV infection in humans is transmitted by mosquitoes and induces common symptoms of high fever, arthralgia and myalgia. Because no specific antiviral drugs for treatment of CHIKV infection are available, drug development remains a central goal.

Correction: Choudhary et al. Encapsulation Engineering of Sulfur into Magnesium Oxide for High Energy Density Li-S Batteries. 2024, , 5116.

In the original publication [...

Intrastromal autologous buffy coat as an adjuvant therapy for fungal corneal ulcer: a case report of two cases.

Purpose: To report the hastened recovery of two nonresponding fungal corneal ulcer cases after using intrastromal injections of autologous buffy coat (a component of blood rich in leucocytes) as an adjuvant to topical antifungal therapy.

Methods: Microbiologically proven non-responding cases (>2 weeks of treatment) of fungal corneal ulcers who visited the cornea specialty clinic of our hospital were explained the disease and adjuvant intrastromal autologous buffy coat treatment, which would be repeated if effective. Then, well-informed and written consent was obtained from the patients for the treatment.

Efficacy of Mycophenolate in Steroid-Dependent and Frequently Relapsing Adult Minimal Change Disease: A Retrospective Cohort Study.

Background Just like in the pediatric population, minimal change disease (MCD) in adults is characterized by a high relapse rate following steroid therapy. A significant proportion of these patients become either frequent relapsers or steroid-dependent (SD). These SD or frequently relapsing (FR) adult MCD cases require additional forms of immunosuppressive therapy to avoid steroid-related adverse effects.

Ischemic Stroke in a Young Individual as an Atypical Presentation of Polycythemia Vera.

Polycythemia vera represents a neoplastic proliferative disorder characterized by an abnormal overproduction of cells of myeloid lineage, especially erythrocytes. It can infrequently present as an acute ischemic stroke as the initial manifestation. This presentation is rarer in young patients; hence, it signifies the essence of a complete evaluation to elicit an accurate diagnosis to help prevent morbidity and mortality.

Dry Needling and Its Application in Dentistry: A Review.

Dry needling is a technique increasingly being used across various medical and therapeutic fields, including dentistry. It involves the insertion of fine needles into specific points in muscles or tissues to alleviate pain and promote healing. This paper explores the application of dry needling within the field of dentistry, outlining its efficacy in treating conditions such as temporomandibular joint disorders (TMD), myofascial pain, and other musculoskeletal issues related to oral health.

Advancing vegetable genetics with gene editing: a pathway to food security and nutritional resilience in climate-shifted environments.

As global populations grow and climate change increasingly disrupts agricultural systems, ensuring food security and nutritional resilience has become a critical challenge. In addition to grains and legumes, vegetables are very important for both human and animals because they contain vitamins, minerals, and fibre. Enhancing the ability of vegetables to withstand climate change threats is essential; however, traditional breeding methods face challenges due to the complexity of the genomic clonal multiplication process.

Transformative approaches in SARS-CoV-2 management: Vaccines, therapeutics and future direction.

The global healthcare and economic challenges caused by the pandemic of COVID-19 reinforced the urgent demand for quick and effective therapeutic and preventative interventions. While vaccines served as the frontline of defense, antivirals emerged as adjunctive countermeasures, especially for people who developed infection, were immunocompromised, or were reluctant to be vaccinated. Beyond the serious complications of SARS-CoV-2 infection, the threats of long-COVID and the potential for zoonotic spillover continue to be significant health concerns that cannot be overlooked.

Microneedle patches: the next frontier in cardiovascular care.

Myocardial infarction is a condition where the heart muscle is damaged due to clogged coronary arteries. There are limited treatment options for treating myocardial infarction. Microneedle patches have recently become popular as a possibly viable therapy for myocardial.

Ribosome profiling reveals differences in global translational vs transcriptional gene expression changes during early biofilm formation.

a major human fungal pathogen, can form biofilms on a variety of inert and biological surfaces. biofilms allow for immune evasion, are highly resistant to antifungal therapies, and represent a significant complication for a wide variety of immunocompromised patients in clinical settings. While transcriptional regulators and global transcriptional profiles of biofilm formation have been well-characterized, much less is known about translational regulation of this important virulence property.

Substituent-Driven ESIPT in Chromeno-Pyrroloquinoline Probe for Differentiating Normal and Cancer Cells.

Despite significant advancements in the structural flexibility and functional diversity of fluorescent molecular sensors, the chromophores often require complex synthetic processes and are typically designed to perform only a specific function. In this work, we have demonstrated the unique features of fluorophores based on a fused coumarin-indole scaffold, which are synthetically available via a one-step reaction. Four fluorophores (ICH, ICEst, ICOMe, and ICNMe) with varying substituents were synthesized and characterized.

Organic Spacers Modulated Low Dose X-Ray Detection in Hybrid Halide 2D Perovskites: Unveiling Exciton Dynamics.

In this study, we investigate how modulating organic spacers in perovskites influences their X-ray detection performance and reveal the mechanism of low-dose detection with high sensitivity using femtosecond-transient absorption spectroscopy (fs-TAS). Particularly, we employ N,N,N',N'-tetramethyl-1,4-phenylenediammonium (TMPDA) and N,N-dimethylphenylene-p-diammonium (DPDA) as organic spacers to synthesize 2D perovskite single crystals (SCs). We find that DPDA-based SCs exhibit reduced interplanar spacing between inorganic layers, leading to increased lattice packing.

Expression of concern: Graphene oxide: an efficient and reusable carbocatalyst for aza-Michael addition of amines to activated alkenes.

Expression of concern for 'Graphene oxide: an efficient and reusable carbocatalyst for aza-Michael addition of amines to activated alkenes' by Sanny Verma , , 2011, , 12673-12675, https://doi.org/10.1039/C1CC15230K.

Does early heart rate detection and continuous monitoring have an impact on neonatal resuscitation in newborns with intact cord? - An observational study.

Context: Heart rate (HR) is the most vital parameter to assess hemodynamic transition at birth. ECG is considered a gold standard for HR assessment. New devices with dry electrodes are easy to apply on a wet newborn.

Evolved and Plastic Gene Expression in Adaptation of a Specialist Fly to a Novel Niche.

How gene expression evolves to enable divergent ecological adaptation and how changes in gene expression relate to genomic architecture are pressing questions for understanding the mechanisms enabling adaptation and ecological speciation. Furthermore, how plasticity in gene expression can both contribute to and be affected by the process of ecological adaptation is crucial to understanding gene expression evolution, colonisation of novel niches and response to rapid environmental change. Here, we investigate the role of constitutive and plastic gene expression differences between host races, or host-specific ecotypes, of the peacock fly Tephritis conura, a thistle bud specialist.