Publications by authors named "Chouchene Saoussen"
Are Healthcare Professionals Adequately Trained for Safe Blood Transfusions? Targeted Training to Bridge Knowledge Gaps.
Indian J Hematol Blood Transfus
October 2024
Introduction: Ensuring optimal blood transfusion practices relies on a robust expertise base that is indispensable across various professional fields. Recognizing this imperative, the current study aims to assess the knowledge levels of healthcare personnel and enhance transfusion quality through targeted continuing training initiatives.
Methods: The preliminary survey was based on an anonymous questionnaire and we used correct response rate (CRR) as the main parameter evaluating the baseline level of knowledge.
Article Synopsis
- Microscopy is the standard method for diagnosing malaria, but its accuracy can vary based on the experience of the examiner and the level of parasites present, making molecular biology a valuable alternative.
- A study was conducted from September 2020 to April 2021 in the Monastir region to assess the effectiveness of three detection methods for malaria in students, revealing that nested PCR identified cases missed by microscopy.
- The findings suggest that nested PCR is more sensitive for detecting low levels of malaria parasites, highlighting the need to incorporate molecular biology techniques into malaria screening for better identification of imported cases.
Article Synopsis
- The study investigates the frequency of HLA alleles in the central Tunisian population to understand their ethnic origins, as previous anthropological research in this area has been limited.
- Using genotyping on 272 healthy organ donors, the researchers identified and compared HLA alleles and haplotypes with various populations, including Arabs, Berbers, and Europeans, through various genetic analyses.
- The results show that central Tunisians share closer genetic similarities with other Tunisian and North African populations, as well as Iberians, while being more distantly related to sub-Saharan Africans and Eastern Mediterranean groups, despite significant cultural and religious influences from Arab populations.
Our study is the first study to investigate the effect of SNPs in CYP3A5, CYP3A4, ABCB1 and POR genes on the incidence of tremors, nephrotoxicity, and diabetes mellitus. A total of 223 renal transplant patients receiving tacrolimus and mycophenolate mofetil (MMF) were recruited. Both adults and children patients participated in the study.
View Article and Find Full Text PDFBackground: Vascular endothelial growth factor A (VEGFA) is well acknowledged as a powerful angiogenesis-promoting agent mainly through its receptor VEGFR2. Ischemia stimulates VEGFA/VEGFR2 signaling pathway and elevated serum levels of VEGFA were detected in coronary heart disease (CHD) patients. The goal of the current study is to determine how four SNPs in the genes for VEGFA (rs3025039 and rs699947) and VEGFR2 (rs2305948 and rs1870377) contribute to the development of CHD.
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- Coronary artery disease (CAD) can lead to myocardial infarction (MI), which increases the risk of sudden cardiac death (SCD) and ventricular arrhythmias (VA).
- The study aimed to link specific genetic variations (SNPs) in genes related to heart arrhythmias with the likelihood of developing VA during an MI.
- Results indicated that two SNPs, specifically in the SCN5A and SCN10A genes, were significantly connected to a higher risk of VA in MI patients, which could potentially help in predicting and preventing SCD.
Thiopurine-S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs. Significant interethnic variation in the expression of TPMT and ITPA is caused by single nucleotide polymorphisms of genes encoding these proteins. The aim of this study was to describe the distribution of TPMT and ITPA polymorphisms in healthy Tunisian subjects and to establish the metabolizer status of thiopurine drugs in this population.
View Article and Find Full Text PDFPurpose: Clopidogrel non-responsiveness is multifactorial; several genetic and non-genetic factors may contribute to impaired platelet inhibition. The goal of this study is to determine the effect of the cytochrome P450 CYP2C19*2 polymorphism on the platelet response to clopidogrel in patients with and without diabetes mellitus (DM).
Methods: We conducted an observational study in patients with coronary artery disease and consequent exposure to clopidogrel therapy (75 mg/day for at least 7 consecutive days).
There is evidence that diet and variation in lipid metabolism can influence blood coagulation, but little is known about the effect of Ramadan fasting on plasmatic coagulation pattern. We investigated the effect of Ramadan fasting on thrombin generation (TG) in patients with cardiovascular disease (CVD) risks, and we aimed to assess the effect of lipid profile on TG parameters. The study was conducted in 36 adults having at least 2 CVD risks and in 30 healthy controls.
View Article and Find Full Text PDFPlatelet satellitism is considered an uncommon phenomenon with an estimated frequency at 0.008%. About 100 cases have been published.
View Article and Find Full Text PDFThe aim of this pilot study was to compare the effect of two different regimens of aspirin dosage on platelet of coronary artery disease (CAD) diabetic patients. Twenty-five CAD diabetic patients were included. Initially, all patients received aspirin 100 mg/day for 10 days.
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