Publications by authors named "Chorong Han"
Article Synopsis
- The study aimed to explore the circadian rhythms in the trigeminal ganglion of mice, which are relevant to understanding headache disorders like migraines and cluster headaches.
- Researchers used a combination of ex vivo and single-cell cultures, along with behavioral and genetic analyses, to assess the influences of these rhythms on pain sensitivity in a nitroglycerin-induced headache model.
- Results revealed significant circadian patterns in gene expression and pain sensitivity, including the identification of potential gene targets for therapies that align with these rhythms.
Background And Objectives: Cluster headache and migraine have circadian features at multiple levels (cellular, systems, and behavioral). A thorough understanding of their circadian features informs their pathophysiologies.
Methods: A librarian created search criteria in MEDLINE Ovid, Embase, PsycINFO, Web of Science, and Cochrane Library.
Numerous molecular and physiological processes in the skeletal muscle undergo circadian time-dependent oscillations in accordance with daily activity/rest cycles. The circadian regulatory mechanisms underlying these cyclic processes, especially at the post-transcriptional level, are not well defined. Previously, we reported that the circadian E3 ligase FBXL21 mediates rhythmic degradation of the sarcomere protein TCAP in conjunction with GSK-3β, and Psttm mice harboring an Fbxl21 hypomorph allele show reduced muscle fiber diameter and impaired muscle function.
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- Alzheimer's disease (AD) is a serious condition affecting brain function, and researchers are searching for ways to modify the disease and develop effective treatments.
- The study investigated the effects of Nobiletin (NOB), a natural compound that enhances the circadian clock, in a double transgenic AD mouse model.
- Results showed that NOB reduced β-amyloid levels in the brain and improved aspects of cognitive function while also dampening neuroinflammation, particularly by decreasing astrogliosis.
Dysregulated circadian functions contribute to various diseases, including cardiovascular disease. Much progress has been made on chronotherapeutic applications of drugs against cardiovascular disease (CVD); however, the direct effects of various medications on the circadian system are not well characterized. We previously conducted high-throughput chemical screening for clock modulators and identified an off-patent anti-arrhythmic drug, moricizine, as a clock-period lengthening compound.
View Article and Find Full Text PDFVerapamil is the first-line preventive medication for cluster headache, an excruciating disorder with strong circadian features. Whereas second- and third-line preventives include known circadian modulators, such as melatonin, corticosteroids, and lithium, the circadian effects of verapamil are poorly understood. Here, we characterize the circadian features of verapamil using both in vitro and in vivo models.
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