Chelation-Tamoxifen Conjugates for Imaging of Estrogen Receptors.

The differential diagnosis of estrogen receptor-positive (ER+) pathway-activated systems by using a labeled antiestrogen helps to select the patients for optimal response to endocrine therapy and to discontinue the treatment when resistance occurs. The authors' purpose was to synthesize chelator-tamoxifen conjugates for imaging ER (+) diseases. A hydroxypropyl linker was incorporated between either cyclam or cyclam diacetic acid and tamoxifen analog to produce SC-05-L-1 (Z-1-(1,4,8,11-tetraazacyclotetradecan-1-yl)-3-((5-(4-(2-(diethylamino)ethoxy)phenyl)-4,5-diphenylpent-4-en-1-yl)oxy)propan-2-ol) and SC-05-N-1 (Z-2,2'-(4-(3-((5-(4-(2-(diethylamino)ethoxy)phenyl)-4,5-diphenylpent-4-en-1-yl)oxy)-2-hydroxy-propyl)-1,4,8,11-tetraazacyclotetradecane-1,8-diyl)diacetic acid), respectively.

Factors affecting Taiwanese women's choice of Cesarean section.

The rising rate of cesarean section (CS) is a subject of concern, intensive discussion, and investigation. However, few, if any, systematic studies of this trend have been recorded among the oriental populations. This study examines factors that may contribute to the high incidence of CS in Taiwan, where the rate of CS is among the highest in the world.

Mining three-dimensional anthropometric body surface scanning data for hypertension detection.

Hypertension is a major disease, being one of the top ten causes of death in Taiwan. The exploration of three-dimensional (3-D) anthropometry scanning data along with other existing subject medical profiles using data mining techniques becomes an important research issue for medical decision support. This research attempts to construct a prediction model for hypertension using anthropometric body surface scanning data.

Waist-to-thigh ratio can also be a better indicator associated with type 2 diabetes than traditional anthropometrical measurements in Taiwan population.

Purpose: Using three-dimensional (3D) scanning data along with other existing subject's medical profiles to search for better anthropometric markers in association with type 2 Diabetes Mellitus (DM).

Methods: In this cross-sectional study with 6007 subjects undergoing health examination in a period of 3 years, the authors adopted data from 3D scanning with hundreds of body measures and conducted factor analysis to search for practical indicators better associated with type 2 DM. A multiple logistic regression model was used to analyze strength of association between indicators and presence of type 2 DM.

Case payment and the adoption of new technology: an empirical study of cataract surgery in Taiwan.

Background: Case payment for cataract surgery with Government Employee Insurance (GEI) was implemented at Chang Gung Memorial Hospital (CGMH) in March 1994, and fee-for-service (FFS) was retained for cataract inpatients with or without other health insurance. We examined the impact of this change in the reimbursement policy from FFS to case payment on the health care provider's practice behavior towards a new emerging technology, using cataract surgery as an example.

Methods: Secondary data analysis was performed using 1 year of CGMH data before (period 1, from March 1993 to February 1994) and after (period 2, from March 1994 to February 1995) implementing the new policy.