Publications by authors named "Chorng-An Liao"
Article Synopsis
- Metabolic-associated fatty liver disease (MAFLD) is linked to metabolic issues and elevated uric acid (UA) levels, with growing evidence suggesting gut microbiota plays a role in these disturbances.
- A clinical trial tested the effects of probiotics—Lactobacillus fermentum TSF331, Lactobacillus reuteri TSR332, and Lactobacillus plantarum TSP05—on liver function and UA levels in participants with abnormal enzyme levels, involving 82 individuals over 60 days.
- Results showed significant reductions in liver enzymes (AST, ALT) and UA levels, improvements in gut bacteria composition, and in vitro evidence of reduced lipid accumulation, indicating potential treatment benefits for asymptomatic MAFLD
Depression is a medical and social problem. Multiple metabolites and neuroinflammation regulate it. Modifying the gut microbiota with probiotics to reduce depression through the gut-brain axis is a potential treatment strategy.
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- Nonalcoholic fatty liver disease (NAFLD) is linked to metabolic issues like obesity and insulin resistance, and the study examines how pterostilbene (Pt) and its derivative 3'-hydroxypterostilbene (OHPt) impact fatty liver conditions.
- The findings show that both compounds reduce lipid accumulation in liver cells and mice on a high-fat diet by activating key metabolic pathways that promote fat breakdown and improve insulin signaling.
- OHPt was found to be more effective than Pt, suggesting potential benefits for treating NAFLD and enhancing liver health in future clinical applications.
Bifidobacterium animalis CP-9 was a commensal strain isolated from human breast milk. In this study, genetic and 90-day oral toxicity were assessed in rodents for its safety. Ames test as well as in vivo bone marrow micronucleus and spermatocyte chromosomal aberration were surveyed in mice.
View Article and Find Full Text PDFObesity is referred to as a condition in which excess body fat has accumulated to an extent that it causes negative impacts on health. The formation of body fat is regulated by complicated networks in relation to energy metabolism, and gut microbiota have been regarded as a key player. Studies have shown that supplements of probiotics provide benefits to health, including an improvement in metabolic syndrome and the control of body weight.
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