Adverse events associated with currently used medical treatments for cystinuria and treatment goals: results from a series of 442 patients in France.

Objective: To evaluate medical treatments, in terms of adverse events (AEs) and therapeutic goals, in a large series of patients with cystinuria.

Patients And Methods: Data from 442 patients with cystinuria were recorded retrospectively. Crystalluria was studied in 89 patients.

CKD and Its Risk Factors among Patients with Cystinuria.

Background And Objectives: Cystinuria is an autosomal recessive disorder affecting renal cystine reabsorption; it causes 1% and 8% of stones in adults and children, respectively. This study aimed to determine epidemiologic and clinical characteristics as well as comorbidities among cystinuric patients, focusing on CKD and high BP.

Design, Setting, Participants, & Measurements: This retrospective study was conducted in France, and involved 47 adult and pediatric nephrology and urology centers from April 2010 to January 2012.

Endoscopic treatment of vesicoureteral reflux--a 20-year follow-up.

Endoscopic reflux therapy has gained more and more popularity, and the use of this method is increasing. These imaging patterns (well known by pediatric radiologists) should be known by the general radiologist as the first young patients treated 20 years ago are now adults.

[Primary pleomorphic rhabdomyosarcoma of the kidney in adults: unusual tumor].

Primary rhabdomyosarcoma (RMS) of the kidney in an adult is a very rare and unusual tumor in this site. The clinical signs associated with the flank tumoral syndrome, the histologic appearance of cytoplasmic double striation in rhabdomyoblasts and the immunohistochemical expression of skeletal muscle differentiation (desmin, myoglobin, myogenin) are described in the context of a rapidly evolving renal RMS in a 77-year old man. The differential diagnosis are mainly represented by sarcomatoid renal cell carcinoma.

[Treatment of bladder neck obstructions by the Memotherm stent].

Objective: This study was designed to evaluate the feasibility, efficacy and complications of treatment of bladder neck obstruction by Memotherm stent.

Material And Methods: A Memotherm stent was implanted under local anaesthesia in 53 elderly patients presenting a poor general status and/or cardiopulmonary disease. All patients presented urinary retention, 48 patients presented signs of benign prostatic hyperplasia (BPH) and 5 patients presented neurogenic bladder.

Laparoscopic tumorectomy of renal carcinoma recurred in remaining kidney.

Nephron sparing surgery is the standard treatment for small, peripherally located renal cell carcinoma. To reduce the morbidity of nephron sparing surgery laparoscopy was proposed. A case of renal carcinoma recurred in the remaining kidney successfully treated by laparoscopic approach is reported.

Iatrogenic bladder stone formation on absorbable suture 3-years after radical prostatectomy.

Vesical calculi formation on absorbable sutures is rare. The case of a 68-year-old white man, who had formed a large bladder stone on absorbable suture 3 years after radical prostatectomy, is reported. Endoscopic lithotripsy of the bladder calculi was performed and the suture was removed.

Successful transarterial embolization of idiopathic renal arteriovenous fistula.

A case of idiopathic renal arteriovenous fistula in a 46-year-old woman presenting intensive right renal colic associated to massive hematuria is reported. The renal arteriography confirmed the diagnosis and embolization of the fistula was performed. The transarterial embolization was successful no recurrence is observed after one year follow-up.

[Apropos of 1 case of paratesticular papillary serous cystadenocarcinoma].

The occurrence within the testis or paratesticular tissue of serous tumors, similar to ovarian tumors, is rare. This article reports a primary serous paratesticular cystadenocarcinoma in a 39 year-old man. From data of the literature, we offer guidelines for diagnosis, histogenesis and treatment of this rare tumor.

[Radiotherapy of localized prostatic cancer: follow-up of 48 patients. G.C.C.P. (Cooperative Group for the Study of Prostatic Cancer)].

Objective: To evaluate the safety and long-term efficacy of curative-intent radiation therapy in patients with apparently localized prostate cancer.

Method: 48 patients with T < 3 M0 prostate cancer recruited between 1981 and 1985 received regular clinical follow-up for at least ten years or until their death. Radiation therapy was given according to the protocols established by Ray and Bagshaw.

[Results of long-term treatment of inoperable cancer of the bladder with cisplatin and concurrent irradiation: prognostic factors of local control and survival].

Purpose: Therapeutic strategies for muscle invasive bladder cancer are currently evolving. A recent European randomized study has shown that neoadjuvant chemotherapy does not improve the chance of cure or and radiotherapy would provide better results but there is a need to identify by prognostic factors patients who may benefit from such a conservative strategy.

Material And Methods: One hundred and nine patients with localized muscle-invasive bladder cancer, who were not candidates for radical cystectomy, were treated with concomitant cisplatin and radiation therapy.

DNA ploidy by image cytometry in urothelial carcinomas. Comparison of touch imprints and paraffin-embedded biopsies from 31 patients.

Objective: To compare DNA content measured by image cytometry from touch imprints and formalinfixed, paraffin-embedded samples in bladder carcinomas.

Study Design: Thirty-one biopsies of urothelial carcinomas were selected for a prospective study. Imprints of fresh specimens were performed.

[Xanthine urinary calculus in a patient with Lesch-Nyhan syndrome. Apropos of a case].

The authors report a case of xanthine stones in a 12-year-old child with Lesh Nyhan syndrome treated by allopurinol at the dose of 10 mg/kg/24 hours. This type of urinary stone is unusual and its structure was confirmed by spectrophotometric analysis. This type of stone, in the context of Lesh Nyhan syndrome, suggests the presence of allopurinol treatment.

Concurrent cisplatin and radiotherapy for patients with muscle invasive bladder cancer who are not candidates for radical cystectomy.

Purpose: We assessed the results and prognostic factors in patients with bladder cancer treated conservatively with concurrent cisplatin and radiotherapy.

Materials And Methods: A total of 109 patients with localized muscle invasive bladder cancer who were not candidates for radical cystectomy underwent concomitant chemotherapy and radiation. Median patient age was 70 years.

[Unusual tumors of the testis. Apropos of 22 cases].

The authors report their experience of rare non-germ-cell tumours of the testis over a period of 10 years. The criteria of benign disease, justifying testicular preservation in 5 out of 7 cases of epidermoid cysts, are defined. Four cases of Leydig cell tumours, including 3 with gynaecomastia, are described.

[Endoscopic transvesicoparietal exteriorization of ureteral catheters].

Endoscopic introduction of catheter into the ureter for drainage has long been a common procedure, and recent advances in endoscopic urology have widened its indications. The ureteral catheter is usually exteriorized through the urethra and attached to the urethral catheter, but with this technique it tends to descend spontaneously and to create infections which are a possible cause of ureteral stenosis. A technique of endoscopic transvesicoparietal exteriorization of ureteral catheters without incision has been developed in 1982.

[Tumor grafts in the upper urinary tract secondary to tumors of the bladder epithelium].

A retrospective study of cases seen between 1975 and 1985 showed 24 tumors of upper urinary tract secondary to primary bladder localizations. These secondary localizations developed during evolution of multi-resected recurring bladder tumors, within a mean period of 15 months after discovery of a secondary vesicorenal reflux. This reflux is acquired constantly during the course of these tumors and it is undoubtedly responsible for the onset of these upper tract tumoral grafts.

[Recurrence of a urothelial carcinoma in an ileal neo-bladder. Apropos of a case].

Recurrences of bladder carcinoma on ileal loop are rare (8 cases reported). We report herein the first case of recurrence after enterocystoplasty (Camey procedure).

[Treatment and course of advanced bladder cancers. Retrospective study of 29 cases].

A retrospective study of 29 patients with extensive but non metastatic bladder cancer (T234N+ M0) demonstrated once more the dreadful prognosis of advanced bladder cancer. Only 4 patients are alive without evidence of recurrence with a follow up of 12 to 64 months. The 11 patients whose tumor was too extended for radical cystectomy had a similar survival rate and better quality of survival than the 18 patients who underwent total cystectomy.

[Benign prostatic hypertrophy. Surgical treatment. Value of surgery by a high approach].

Transurethral resection of the prostate is not a new procedure for the treatment of adenoma of the prostate but is being increasingly used. This fact is incontrovertible and all urologists perform transurethral resection for small adenomas. For large adenomas we still believe surgical removal is the best method.

[Extensive nephrectomy in severe forms of cancer of the kidney in the adult].

Resection of renal tumours may be useless when the staging procedures reveal that the disease is too far advanced. A retrospective study of 100 radical nephrectomies for renal cell carcinoma distinguished the following groups: advanced cancers in young patients; cancers in patients over the age of 70 years. Despite the limited follow-up of this series, the study of survival demonstrates the following points: the difficulty of predicting the degree of lymph node involvement on pre-operative staging, the value of an anterior sub-costal and abdominal approach which facilitates radical nephrectomy in elderly and fragile patients, the poor prognosis of lymph node invasion and metastases, although some patients have survived for 12 months after resection of metastatic tumours.

[Encysted renal tumor in adults. Apropos of an unusual ultrasonographic and anatomo-pathological case].

Ultrasound imaging in a 45 years old man with a one year history of bladder stone colic treated medically detected a partly encysted tumoral mass in the corticomedullary zone of upper pole of right kidney. Extemporaneous examination, requested because of the original macroscopic appearance of this tumor, prevented excision of right kidney. The atypical microscopic appearances, not found during a literature review, justify reporting of this case.