mRNA TLR2 AND TLR4 EXPRESSION IN THE ENDOMETRIUM TISSUE IN WOMEN WITH ENDOMETRIOSIS ASSOSIATED WITH INFERTILITY.

Endometriosis is an important medical and social problem as it causes stable pelvic pains, afflicts women of the reproductive age, provokes infertility characterized by poor outcome of treatment. In recent times much attention is paid to the mechanisms of congenital immunity as possible mediators of the development of endometriosis and targets of therapy. The work deals with the investigation of the levels of mRNA TLR2 and TLR4 expression in the tissue of eutopic endometrium in women with endometriosis and infertility in comparison with women afflicted with infertility of a tubular character with the aim to define the role of TLR2 and TLR4 in the development of infertility in case of endometriosis.

[Comparative characteristic of the treatment efficacy in patients with often recurrent acute respiratory infections complicated with immunodeficiency treated with likopid].

It was analysed the fascinating and metabolic phagocytic activity of neutrophilis (cationic-protein, myeloperoxidase and latex tests, NST-test: spontaneous and stimulated, stimulation index) in patients with often recurrent acute respiratory infections on the base of immunodeficiency disorders who received sublingual drug Licopid in dose of 1 mg/daily (30 patients) and 3 mg/daily (30 patients) during 14 days. It was found that Licopid in the daily dose of 3 mg could lead to more rapid regression of clinical symptoms of acute respiratory disease, more intensive strengthening neutrophils absorption capacity, metabolic and protease activity, activated by myeloperoxidase and cationic proteins. To improve of neutrophils phagocytic activity in patients with frequent acute respiratory diseases on the base of immunodeficiency disorders it could be recommended to increase the total dose of Licopid to 3 mg/daily and the frequency of repeated courses during the year, especially for patients of immunocompromised group.

[A chronic hyperimmunocomplex process and its interrelationship with free radical-generating systems].

On chronic hyperimmunocomplex process (CHIP) model in rats of Wistar line (Cochrane C., Koffen D., 1973) we determined cAMP and cGMP concentration, nitrogen oxide (NO), urine, urine acid,--in muscle and clearance organs, and also in plasma.

[The immunological characteristics of systemic vasculitis].

A total of 142 patients with systemic vasculitis (SV) during the phase of activation of the process were evaluated. Diagnosis was based on the clinical as well as laboratory, functional and morphologic findings. Immunological investigation revealed increase in T-lymphocyte effector activity, marked sensibilization of lymphocytes to the intimal antigen, hyperimmunocomplexemia, decline in phagocytosis, hypocomplementemia.

[The use of immunotropic therapy in patients with systemic vasculitides].

148 patients with systemic vasculitis (SV) were observed. In 90 of them "in vitro" we evaluated the action of immunotropic mediators (levamisol, timalin, human plasma immunoglobulin, placental polybiolin)--to evaluate the expression of lymphocyte antigens and oxide-renewal phagocyte activity. It was estimated, that the major sensitivity patients--do have lymphocytes to placental polybiolin.

[The participation of neutrophilic mechanisms in the pathogenesis of chronic elevated blood immune complexes].

For reproduction of chronic hyperimmunocomplexemia model the classic Cochrane C. G., 1973 elaboration was used.

[Diagnostic criteria for systemic scleroderma].

Diagnostic informative value was studied of a set of N. G. Guseva's diagnostic criteria (1993) for systemic sclerosis (scleroderma).