S-AMLODIPINE AS A MODERN EFFECTIVE ANTIHYPERTENSIVE AND AN ANTIANGINAL AGENT.

Objective: The aim: Study of the clinical and hemodynamic effects of S-amlodipine in patients with arterial hypertension associated with coronary artery disease, in individuals with preserved LV systolic function.

Patients And Methods: Materials and methods: The study includes 51 patients with arterial hypertension associated with coronary artery disease, who were treated with S-amlodipine.

Results: Results: This study shows the high clinical effectiveness of the use of S-amlodipine in patients with arterial hypertension associated with coronary artery disease.

Comorbidity severity index as a new tool for assessment of co-existing diseases in patients with non-alcoholic fatty liver disease at the carbohydrate metabolism disorder background and concomitant subclinical hypothyroidism.

Objective: Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common disease which is characterized by comorbidity. However, no comorbidity index for its assessment has been described yet. The aim of this study was to develop a new index for evaluation of comorbidity in patients with NAFLD.

[Clinical and endoscopic efficacy of vedolizumab in patients with ulcerative colitis].

Objective: Introduction: Ulcerative colitis (UC) is a chronic recurrent idiopathic inflammatory bowel disease that is characterized by a continuous or wave-like course with multifactorial etiopathogenesis. In recent decades, the number of patients with this pathology has been steadily increasing. Therefore, timely detection of UC at the diagnostic stage for the further qualified assistance providing is one of the most important tasks in modern gastroenterology.

[Dynamics of staphylococcus aureus antibiotic resistance to fluoroquinolones in vitro in patients with overweight].

Objective: Introduction:S. aureus is the main pathogen of skin, soft tissue and otorhinolaryngological infections as well as the cause of osteomyelitis, meningitis and endocarditis. In recent years the importance of S.

Subclinical hypothyroidism in patients with non-alcoholic fatty liver disease at the background of carbohydrate metabolism disorders.

Objective: Introduction: The prevalence of non-alcoholic fatty liver disease (NAFLD) is 25-30% in the general population and more than 75% among patients with carbohydrate metabolism disorders. One in six patients with NAFLD has concomitant subclinical hypothyroidism. The aim is to compare lipid and carbohydrate metabolism states in patients with NAFLD depending on the functional state of the thyroid gland.

[The assessment of cardiovascular risk factors in patients with nonalcoholic fatty liver disease].

Article presents the result of assessmaent of cardiovascular risk factors in patients with nonalcoholic fatty liver disease (NAFLD). The results show the presence of cardiovascular risk factors in patients with NAFLD, namely the increase of waist and hip circumferences compared with patients of the control group, hyperglycemia and dyslipidemia, decrease in apolipoprotein A1 (AroA1) compared to practically healthy people.

[The value of transendoscopy thermometry of gastric mucosa in the evaluation of blood flow in patients with osteoarthrosis and atherosclerosis by duplex ultrasound of extracranial brachiocephalic arteries].

The pathogenesis of gastric mucosa lesions in elderly and senile people has many factors. It's based on contradiction between protective factors (mucus secretion, prostaglandins, bicarbonate, microcirculation, regeneration, etc.) and aggression factors (hydrochloric acid, pepsin, bile acids, pancreatic enzymes, bacteria).

[Treatment optimization of subclinical atherosclerosis in patients with ulcerative colitis].

In this article we assessed the positive impact of statins and omega-3 polyunsaturated fatty acids on achieving target lipid levels, acute phase proteins in patients with ulcerative colitis and subclinical atherosclerosis.

[Risk factors of cardiovascular disease in patients with ulcerative colitis].

This article presents an analysis of the traditional risk factors for adverse cardiovascular events in patients with ulcerative colitis. In addition, special attention is given to additional ("new") cardiovascular risk factors.

[Cardiovascular continuum: the role of the family doctor in prevention of cardiovascular diseases].

Cardiovascular diseases are the cause of premature death, but the lifestyle modifications, struggle with the major cardiovascular risk factors can significantly reduce the incidence of coronary events, cerebral vascular lesions and the latter of peripheral arteries. In everyday practice, the elimination of risk factors by the family doctor should be a mandatory part of prevention and treatment programs.

[Influence of Helicobacter pylori eradication on the metabolic syndrome components].

The article presents the results of a study that describes the impact of successful Helicobacter pylori infection eradication on the main biochemical markers of metabolic syndrome. It was found that successful anti-helicobacter therapy in patients with MS was accompanied by statistically significant improvement in carbohydrates and lipid metabolism, the liver functional state, lowering hsCRP levels.

[Effectiveness of short courses of fasting in pre-asthma and asthma patients].

In patients with preasthma and bronchial asthma, short-term courses of fasting dietotherapy (FDT) with a 7-day fasting period proved to be effective, as evidenced by clinical-and-functional and laboratory investigations. The incidence rate of viral infections was much lower with short-term courses compared to long-term courses. Too low an effect, if any, with FDT short-term courses can be explained by excess of the patient's body weight.

[Clinical study of anti-leukotriene therapy with montelukast in bronchial asthma patients].

Clinical and functional efficacy of the antileukotriene agent montelucast (singulair) was investigated in 30 patients with moderately severe bronchial asthma. Patients with a positive FEV1 response to montelukast (61.1%) demonstrated a higher blood level of IgE and sputum eosinophilia.

[The psychosomatic correlations and the antibodies to lung tissue in patients with bronchial asthma].

Forty-four patients with bronchial asthma, aside from clinical and functional evaluation, were studied for the psychological profile (MMPI-test) and the presence of antibodies to the lung tissue. The correlations established were as follows: normal titers of antibodies to the lung tissue--more agreeable and satisfactory psychological profile of the patients, the lower or higher the antibody titer, the less acceptable is the psychological profile.

[The regulation of hydrolytic processes in the small and large intestines].

A study is presented of the effect of different modifiers (analogues of natural food) on the rate of starch hydrolysis in the small and large intestine. Revealed were different changes of the activity of amylase and glycyl-l-leucin-dipeptidase under the effect of B vitamins, Enzaprost F., cimetidine, obsidan, prednisolone, dopamine, ethaden, ethanol.

[The use of parietal pH-metry in the diagnosis of intestinal diseases].

Parietal measurements of pH values in patients with various intestinal diseases and in normal subjects have revealed that alkaline medium with gradual elevation of the values in the caudal direction is characteristics of the normal large intestine; acid pH values were registered in patients with lactase insufficiency, nonspecific ulcerative colitis, in contrast to those with post-dysentery colitis and tumors of the large intestine. Lactulose and sodium sulfate were found the factors that significantly influence the large intestine parietal pH values, the effects of wheat bran were lower; magnesium sulfate and sodium hydrocarbonate mineral water with medium mineral content had no effect on parietal pH values.