Percutaneous endoscopic resection of a large fibroepithelial polyp in the renal pelvis using a resectoscope: a case report.

Background: Fibroepithelial polyp (FEP) in the renal pelvis is a rare benign tumor of the urinary tract. Treatment of such diseases varies from local resection to radical nephroureterectomy, either by open or endoscopic surgery. This study aims to show our successful experience in percutaneous endoscopic resection of FEP.

Photonic compressive sensing of microwave signals with enhanced compression ratio and frequency range via optical pulse random mixing.

We propose and demonstrate a photonic compressive sensing (PCS) scheme for microwave signals using optical pulse random mixing, significantly enhancing both the compression ratio and operating frequency range. Unlike continuous-wave laser-based PCS systems, our approach mitigates the non-ideal characteristics of the pseudo-random binary sequence (PRBS), such as sloped edges and amplitude jitters, resulting in a more ideal compression process. Additionally, the high harmonic components of the optical pulses further facilitate wideband downconversion, improving the system's operating frequency range.

Elucidating stearoyl metabolism and NCOA4-mediated ferroptosis in gastric cancer liver metastasis through multi-omics single-cell integrative mendelian analysis: advancing personalized immunotherapy strategies.

Background: The metabolism of stearoyl-GPE plays a key role in the liver metastasis of gastric cancer. This investigation delves into the mechanisms underlying the intricate tumor microenvironment (TME) heterogeneity triggered by stearoyl metabolism in gastric cancer with liver metastasis (LMGC), offering novel perspectives for LMGC.

Objective: Utilizing Mendelian randomization, we determined that stearoyl metabolism significantly contributes to the progression of gastric cancer (GC).

Research progress on intratumoral microorganisms in renal cancer.

The human body harbors a vast array of microorganisms. Changes in the microbial ecosystem can potentially lead to diseases, including cancer. Traditionally, research has focused more on the gut microbiota and its influence on cancer.

Multifunctional nanoparticles confers both multiple inflammatory mediators scavenging and macrophage polarization for sepsis therapy.

Sepsis is a serious and life-threatening condition, which can lead to organ failure and death clinically. Abnormally increased cell-free DNA (cfDNA) and inflammatory cytokines are involved in the development and progression of sepsis. Thus, cfDNA clearance and down-regulation of inflammatory factors are essential for the effective treatment of sepsis.

Retrospective claims data analysis of ASCT characteristics and costs for working-age, multiple myeloma patients in the US, 2017-2019.

Multiple myeloma (MM) is a rare hematologic malignancy with a 5-year survival rate of 52 %. For transplant-eligible MM patients, high-dose chemotherapy followed by autologous stem cell transplant (ASCT) is recommended. Given the complexities of the ASCT procedure, understanding patient-specific factors and their impact on treatment decisions is essential.

Vibronic Coupling and Multiple Electronic States Effect in ABS and ECD Spectra: Three [7]Helicene Derivatives.

Vibronic coupling and multiple electronic states effect play a pivotal role in the molecular spectroscopy of large systems. Herein, we present a detailed theoretical study on the absorption (ABS) and electronic circular dichroism (ECD) spectra of three [7]helicene derivatives in chloroform, with a particular emphasis on the significance of vibronic coupling and the multiple electronic states effect in spectral simulations. The vertical gradient (VG) and vertical Hessian (VH) models, incorporating the Franck-Condon (FC) effect and Herzberg-Teller (HT) contribution, are considered in the vibronic calculations.

Inhibition of Melanin Synthesis and Inflammation by Exosomes Derived from DB-14 Isolated from Flower.

is a lactic acid bacteria found in fermented products. In our previous study, was isolated from flowers, and its acid tolerance and antibacterial properties were thoroughly investigated. This study focuses on the inhibition of melanin synthesis and inflammation of exosomes derived from .

Integrated multi-omics analysis identifies a machine learning-derived signature for predicting prognosis and therapeutic vulnerability in clear cell renal cell carcinoma.

Aims: Clear cell renal cell carcinoma (ccRCC) shows considerable variation within and between tumors, presents varying treatment responses among patients, possibly due to molecular distinctions. This study utilized a multi-center and multi-omics analysis to establish and validate a prognosis and treatment vulnerability signature (PTVS) capable of effectively predicting patient prognosis and drug responsiveness.

Materials And Methods: To address this complexity, we constructed an integrative multi-omics analysis using 10 clustering algorithms on ccRCC patient data.

Enhancing the visual environment of urban coastal roads through deep learning analysis of street-view images: A perspective of aesthetic and distinctiveness.

Urban waterfront areas, which are essential natural resources and highly perceived public areas in cities, play a crucial role in enhancing urban environment. This study integrates deep learning with human perception data sourced from street view images to study the relationship between visual landscape features and human perception of urban waterfront areas, employing linear regression and random forest models to predict human perception along urban coastal roads. Based on aesthetic and distinctiveness perception, urban coastal roads in Xiamen were classified into four types with different emphasis and priorities for improvement.

An event-based account of conformity: evidence from attention manipulations targeting event-file encoding and retrieval.

Previous findings have raised doubt in whether comparable conformity effects can be obtained for information from humans and computers or other systems of little or no social importance. In the present study, we compared the impact of "other choices" (i.e.

Highly Tension-Strained Copper Concentrates Diluted Cations for Selective Proton-Exchange Membrane CO2 Electrolysis.

Electrolysis of carbon dioxide (CO2) in acid offers a promising route to overcome CO2 loss in alkaline and neutral electrolytes, but requires concentrated alkali cations (typical ≥3 M) to mitigate the trade-off between low pH and high hydrogen evolution reaction (HER) rate, causing salt precipitation. Here we report a strategy to resolve this problem by introducing tensile strain in a copper (Cu) catalyst, which can selectively reduce CO2 to valuable multicarbon products, particularly ethylene, in a pH 1 electrolyte with 1 M potassium ions. We find that the tension-strained Cu creates an electron-rich surface that concentrates diluted potassium ions, contributing to CO2 activation and HER suppression.

Degenerated vision, altered lipid metabolism, and expanded chemoreceptor repertoires enable Lindaspio polybranchiata to thrive in deep-sea cold seeps.

Background: Lindaspio polybranchiata, a member of the Spionidae family, has been reported at the Lingshui Cold Seep, where it formed a dense population around this nascent methane vent. We sequenced and assembled the genome of L. polybranchiata and performed comparative genomic analyses to investigate the genetic basis of adaptation to the deep sea.

Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A-menin to bivalent promoters.

Members of the KMT2C/D-KDM6A complex are recurrently mutated in urothelial carcinoma and in histologically normal urothelium. Here, using genetically engineered mouse models, we demonstrate that Kmt2c/d knockout in the urothelium led to impaired differentiation, augmented responses to growth and inflammatory stimuli and sensitization to oncogenic transformation by carcinogen and oncogenes. Mechanistically, KMT2D localized to active enhancers and CpG-poor promoters that preferentially regulate the urothelial lineage program and Kmt2c/d knockout led to diminished H3K4me1, H3K27ac and nascent RNA transcription at these sites, which leads to impaired differentiation.

Short bouts and long-term exercise reduce sedentary-induced bone loss and microstructural changes by modulating bone formation and resorption in healthy young male rats.

Although the toxic effect of Sedentary behavior (SED) on bone health has been demonstrated in the previous study, the underlying mechanisms of SED, or break SED to bone health remain unclear. In this study, we aim to investigate the effects of sedentary behavior (SED) on bone health, as well as the potential favor effects of moderate to vigorous physical activity (MVPA) and periodic interruptions of SED. To simulate SED, we used small Plexiglas cages (20.

[Comparative study on metabolites in rat liver microsomes, urine, feces and bile between Shuganning Injection and Scutellariae Radix extract].

This study aims to compare the metabolic differences of baicalin and its analogues between Shuganning Injection and Scutellariae Radix extract. Twelve SD rats were randomly divided into a Shuganning Injection group and a Scutellariae Radix extract group, with 6 rats in each group. Their liver microsomes were incubated with the drugs, and then the samples were collected.

Short- and Mid-Term Outcomes Following ALIF and TLIF in L5-S1 Isthmic Spondylolisthesis Patients.

Background: A limited number of studies have compared the outcomes of anterior lumbar interbody fusion (ALIF) to transforaminal lumbar interbody fusion (TLIF) for the treatment of isthmic spondylolisthesis. This study aims to compare postoperative complications between these two surgical approaches.

Methods: A retrospective review was performed using a large national database.

Long-term and seasonal evaluation on environmental microbiology and water quality of Shanmei reservoir in southeast China.

As a crucial source of potable water, the quality of water in Shanmei reservoir strongly and directly impacts the safety and well-being of downstream residents. Microorganisms play a pivotal role in the reservoir's resource and energy cycle. However, ecological protection efforts for the Shanmei reservoir have encountered numerous challenges in recent years.

Synthesis, structures, and optical properties of N-heterocycle and amino acid ester-coordinated BH.

A series of N-Het·BH and AAE·BH complexes were prepared in moderate to high yields and the single-crystal structures of products 3, 31, 34, and 59 were determined. The N-Het·BH and AAE·BH complexes possess high stability, endowing these products with potential applications in luminescent and boron-containing drugs. The optical properties of the representative products have been preliminarily studied.

Single-cell mapping of regulatory DNA:Protein interactions.

Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibility and histone modifications. These complex networks have been shown to be disrupted during aging, disease, and cancer. However, profiling these networks across diverse cell types and states has been limited due to the technical constraints of existing methods for mapping DNA:Protein interactions in single cells.

Choroid vascular index in myopic patients - A mini review.

Myopia has become a globally prevalent ocular disease. The choroid plays a vital role in myopia, and its changes tend to occur earlier than those of the retina and long-term variations in eye growth. Abnormal axial growth is an intrinsic characteristic of myopia, accompanied by ocular biomechanical changes that result in chorioretinal atrophy, thinning, and other complications particularly in the choroidal vasculature.

Exploration of milk flavor: From the perspective of raw milk, pasteurized milk, and UHT milk.

In this study, raw milk was collected from three different grades of pastures and processed by pasteurization, blending and ultra-high temperature sterilization (UHT) in a factory production line with a feed size of 10 tons. Additionally, all samples (from raw milk to UHT milk samples) were analyzed by -nose and GC-MS. Key flavor compounds such as 2-heptanone, hexanal, nonanal, 3-methyl-butanal, and dimethyl sulfide were found.

Comparative Analysis of the Benefits of Glutathione-Rich Yeast Hydrolysate and Astaxanthin on Growth Performance, Antioxidant Capacity and Lipid Metabolism in Pacific White Shrimp (Litopenaeus vannamei).

Antioxidants, both glutathione (GSH) and astaxanthin (AX), possess beneficial applications in animal growth and antioxidant properties. In this study, three experimental diets with isoproteic and isolipidic were formulated, the control diet (CON), the control diet added with 0.03% Carophyll Pink (contains 10% AX), the control diet added with 0.

Evaluation of the therapeutic effects of nebulized inhalation of hydrogen-rich water on primary blast lung injury in C57BL/6 mice.

Background: Primary blast lung injury is a common and severe consequence of explosion events, characterized by immediate and delayed effects such as apnea and rapid shallow breathing. The overpressure generated by blasts leads to alveolar and capillary damage, resulting in ventilation-perfusion mismatch and increased intrapulmonary shunting. This reduces the effective gas exchange area, causing hypoxemia and hypercapnia.

Genomic characterization reveals distinct mutational landscape of acral melanoma in East Asian.

Acral melanoma, the most common melanoma subtype in East Asia, is associated with a poor prognosis. This study aims to comprehensively analyze the genomic characteristics of acral melanoma in East Asians. We conduct whole-genome sequencing of 55 acral melanoma tumors and perform data mining with relevant clinical data.