Enhancing cancer therapy: advanced nanovehicle delivery systems for oridonin.

Oridonin (ORI), an ent-kaurane diterpenoid derived from Rabdosia rubescens (Hemsl.) H.Hara, serves as the primary bioactive component of this plant.

The combination of modified acupuncture needle and melittin hydrogel as a novel therapeutic approach for rheumatoid arthritis treatment.

Rheumatoid arthritis (RA) involves chronic joint inflammation. Combining acupuncture and medication for RA treatment faces challenges like spatiotemporal variability, limited drug loading in acupuncture needles, and premature or untargeted drug release. Here, we designed a new type of tubular acupuncture needles, with an etched hollow honeycomb-like structure to enable the high loading of therapeutics, integrating the traditional acupuncture and drug repository into an all-in-one therapeutic platform.

Automatic analysis framework based on 3D-CT multi-scale features for accurate prediction of Ki67 expression levels in substantial renal cell carcinoma.

Purpose: To investigate the effectiveness of an automatic analysis framework based on 3D-CT multi-scale features in predicting Ki67 expression levels in substantial renal cell carcinoma (RCC).

Methods: This retrospective study was conducted using multi-center cohorts consisting of 588 participants with pathologically confirmed RCC. The participants were divided into an internal training set (n = 485) and an external testing set (n = 103) from four and one local hospitals, respectively.

Relationship between MTHFR C677T, homocysteine, and ischemic stroke in a large sample of the Han Chinese population.

Ischemic stroke, one of the prevalent causes of death and disability worldwide, is linked to environmental and genetic factors, including polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene involved in homocysteine metabolism. The present study aimed to explore the relationship between the MTHFR C677T variant, plasma homocysteine, and risk of developing large-artery atherosclerotic ischemic stroke (LAAIS) among Han Chinese. A population-based case-control study, which included 1810 patients with LAAIS and 1765 unrelated control subjects, was conducted.

Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy.

X-ray-induced photodynamic therapy utilizes penetrating X-rays to activate reactive oxygen species in deep tissues for cancer treatment, which combines the advantages of photodynamic therapy and radiotherapy. Conventional therapy usually requires heavy-metal-containing inorganic scintillators and organic photosensitizers to generate singlet oxygen. Here, we report a more convenient strategy for X-ray-induced photodynamic therapy based on a class of organic phosphorescence nanoscintillators, that act in a dual capacity as scintillators and photosensitizers.

Activating room-temperature phosphorescence of 1,8-naphthalimide by doping into aromatic dicarboxylic acids.

The room-temperature phosphorescence of 1,8-naphthalimide was activated by doping it into aromatic dicarboxylic acids. The doping system gives a bright yellow afterglow and 1,8-naphthalimide and isophthalic acid (0.02 mol% doping content) afford a phosphorescent lifetime of 403 ms and a quantum yield of 4.

A 3D Iodoplumbate Semiconducting Open Framework with Visible-light-induced Photocatalytic Performance.

Employing in situ N-alkylation of the conjugated compound 9,10-bis(4-pyridyl)anthracene (bpanth) as structure-directing agent, a 3D inorganic-organic hybrid iodoplumbate, [Me (bpanth)][Pb I ] (1), was solvothermally prepared. The in situ N-alkylation of bpanth with alcohols was investigated. 1 features a novel 3D open framework based on an interesting Pb I cluster.

Assessment of frequent litter amendment application on ammonia emission from broilers operations.

Unlabelled: Litter amendments have been used to control the ammonia (NH3) emission from the broiler litter during the brooding period. One of the commercially available litter amendments, sodium bisulfate, was frequently applied on the litter with two different rates on weekly basis in a laboratory setup and with a single rate on biweekly basis under field conditions. Repeated application ofsodium bisulfate led to significant reduction in NH3 emissions from broilers.