Endometrial Cancer Detection by DNA Methylation Analysis in Cervical Papanicolaou Brush Samples.

Endometrial cancer (EC) is the leading gynecological cancer worldwide, yet current EC screening approaches are not satisfying. The purpose of this retrospective study was to evaluate the feasibility and capability of DNA methylation analysis in cervical Papanicolaou (Pap) brush samples for EC detection. We used quantitative methylation-sensitive PCR (qMS-PCR) to determine the methylation status of candidate genes in EC tissue samples, as well as cervical Pap brushes.

Resilience patterns of urban road networks under the worst-case localized disruptions.

Recent events, including COVID-19, extreme floods, and explosion accidents, commonly induced localized closures and disruptions of urban road networks (URNs), resulting in significant impacts on human mobility and socio-economic activities. Existing studies on URN resilience to those events mainly took few cases for empirical studies, limiting our understanding on the URN resilience patterns across different cities. By conducting a large-scale nationwide resilience analysis of URNs in 363 cities in mainland China, this study attempts to uncover the resilience patterns of URNs against the worst-case single (SLDs) and multiple localized disruptions (MLDs).

Boundary effects on topological characteristics of urban road networks.

Urban road networks (URNs), as simplified views and important components of cities, have different structures, resulting in varying levels of transport efficiency, accessibility, resilience, and many socio-economic indicators. Thus, topological characteristics of URNs have received great attention in the literature, while existing studies have used various boundaries to extract URNs for analysis. This naturally leads to the question of whether topological patterns concluded using small-size boundaries keep consistent with those uncovered using commonly adopted administrative boundaries or daily travel range-based boundaries.

First Report of Colletotrichum fructicola Causing Anthracnose on Rosa chinensis in China.

China rose (Rosa chinensis Jacq.) is a popular ornamental plant grown widely in China. In September 2021, a serious leaf spot disease was observed on R.

High-Temperature Oxidation Behavior of Fe-10Cr Steel under Different Atmospheres.

Using a thermogravimetric analyzer (TGA), Fe-10Cr steel was oxidized in dry air and in a mixed atmosphere of air and water vapor at a relative humidity of 50% and a temperature of 800-1200 °C for 1 h. The oxidation weight gain curves under the two atmospheres were drawn, the oxidation activation energy was calculated, and the phase and cross-sectional morphology of the iron oxide scales were analyzed and observed by X-ray diffractometry (XRD) and optical microscopy (OM). The results showed that when the oxidation temperature was 800 °C, the spheroidization of Fe-10Cr steel occurred, and the oxidation kinetics conformed to the linear law.

Theoretical investigation on the chemoselective N-heterocyclic carbene-catalyzed cross-benzoin reactions.

A density functional theory study was performed to understand the detailed mechanisms of the cross-benzoin reactions catalyzed by N-heterocyclic carbene (NHC) species. Our theoretical study predicted that the first H-transfer operates with water in solution as a mediator, and the second H-transfer undergoes a concerted mechanism rather than a stepwise one. In addition, the chemoselectivity of the reactions studied in this work has been explored.