Damage analysis and grading control technology of surrounding rock in high geo-stress roadway.

To investigate the failure mechanism and establish stability control methods for surrounding rock in high geo-stress roadways, this study incorporated the brittle failure characteristics of the surrounding rock mass into a unified strength criterion, developing an elastic-plastic theoretical model to represent rock damage and fracture. Using this model, analytical expressions for the damage rupture radius and stress field distribution are derived, leading to the proposal of a grading control method. The analysis of calculation examples reveals that an increase in stress, damage degree, and the brittleness coefficient of the rock mass results in the expansion of both the plastic damage and damage residual zones.

Analysis of the safety and effectiveness of TACE combined with targeted immunotherapy in the treatment of intermediate and advanced hepatocellular carcinoma.

To evaluate the effectiveness and safety of transarterial chemoembolization (TACE) combined with immune and targeted therapy in unresectable hepatocellular carcinoma (HCC). Prospective analysis of 23 patients with intermediate or advanced primary HCC treated at the Department of Hepatic Surgery, The First Affiliated Hospital of the University of Science and Technology of China from July 2019, including 11 cases treated with TACE alone and 12 cases treated with TACE combined with targeted therapy. The basal indexes of patients in the two groups were compared, and the response during treatment was observed; regular follow-up was performed to assess the efficacy of tumor treatment.