Meta-Analysis of Capecitabine versus 5-Fluorouracil in Advanced Gastric Cancer.

Objective: To investigate the effect of capecitabine versus 5-fluorouracil in advanced gastric cancer patients.

Methods: We searched PubMed, Cochrane Library, Embase, and other databases from database establishment to June 2022, containing randomized controlled trials (RCT) on capecitabine and 5-fluorouracil in advanced gastric cancer patients. A meta-analysis was conducted to evaluate the effect of capecitabine versus 5-fluorouracil on overall response rate, neutropenia, thrombocytopenia, stomatitis, hand-foot syndrome, nausea and vomiting, alopecia, and diarrhea.