Cystatin B Promotes the Proliferation, Migration, and Invasion of Intrahepatic Cholangiocarcinoma.

: Cystatin B (CSTB) has been demonstrated to play a significant role in the pathogenesis of a number of diseases, including the evolution and progression of multiple cancers. Nevertheless, the function of CSTB in intrahepatic cholangiocarcinoma (iCCA) is yet to be fully elucidated. : By analyzing transcriptome sequencing data from the FU-iCCA cohort, the iCCA-27 cohort, and three public databases, we identified genes associated with iCCA prognosis and selected CSTB as the subject of our study.

Exploring the Efficacy and Target Genes of Against Alzheimer's Disease Based on Multi-Omics, Computational Chemistry, and Experimental Verification.

Objective: To unveil the efficacy and ferroptosis-related mechanisms of (AMK) against Alzheimer's disease (AD), which is the most widespread neurodegenerative disease.

Methods: Gene set variation analysis (GSVA) scores were used to investigate the relationship between ferroptosis and AD. Logistic regression with seven feature selections and a deep learning model were utilized to identify potential targets of AMK based on transcriptomic data from multiple tissues.

Both Jasmonic Acid- and Abscisic Acid-Mediated Signalling Pathways Regulate the Ovicidal Defence of Plants Against Phloem-Feeding Insects.

Plants perceive signals associated with herbivore eggs and in response initiate ovicidal defence. However, which phytohormone pathways regulate this defence and which defensive compounds dominate it remains largely unknown. Here, we found that the hatching rate of eggs of white-backed planthopper (WBPH) Sogatella furcifera was significantly lower on a japonica rice variety P81 than an indica rice variety NB44.

Dual-Function Hydrogel Coating on Silicone Urinary Catheters with Durable Antibacterial Property and Lubricity.

Silicone urinary catheters are broadly employed in medical practice. However, they are susceptible to inducing catheter-associated urinary tract infections (CAUTIs) due to bacterial adherence to the catheter's surface, and they exhibit a high friction coefficient, which can greatly affect their effectiveness and functionality. Thus, the development of a silicone urinary catheter with antibacterial properties and lubricity is in strong demand.

Chiral Supramolecular Hydrogels Regulating Both Osteoblastogenesis and Osteoclastogenesis.

Osteoporosis, a chronic bone disorder, poses a global threat to the health of millions of individuals. The disruption of bone homeostasis is the fundamental cause of osteoporosis. Currently, clinical drugs are employed to promote bone formation via enhancing osteogenesis and/or reduce bone loss via inhibiting osteoclastogenesis.

Advances in 3D and 4D Printing of Gel-Based Foods: Mechanisms, Applications, and Future Directions.

This review examines recent advancements in gel-based 3D and 4D food-printing technologies, with a focus on their applications in personalized nutrition and functional foods. It emphasizes the critical role of tunable rheological and mechanical properties in gels such as starch, protein, and Pickering emulsions, which are essential for successful printing. The review further explores 4D food printing, highlighting stimuli-responsive mechanisms, including color changes and deformation induced by external factors like temperature and pH.

Encapsulation of Fatty Acids Using Linear Dextrin from Waxy Potato Starch: Effect of Debranching Time and Degree of Unsaturation.

This study investigates the effects of the debranching time of waxy potato starch using pullulanase and recrystallization on particle morphology, debranching degree, and crystal structure. The results demonstrated that after gelatinization and debranching, the surface of the starch crystals became rough and uneven due to hydrolysis, with most particles showing a fragmented surface. The crystalline state was not significantly changed with debranching time.

Advancing the Preparation Strategy of High-Performance Integrated Electrodes for eCORR via Sublimation.

The uniform dispersion and loading of phthalocyanine molecular catalysts on conductive carbon substrates are crucial for exposing their active sites. The significant amount of solvent needed to achieve appropriate dispersion of phthalocyanine leads to the risk of reaggregation during solvent evaporation. Hence, a solventless strategy is adopted by many to bypass the use of a solvent.

Indole derivatives ameliorated the methamphetamine-induced depression and anxiety via aryl hydrocarbon receptor along "microbiota-brain" axis.

In addition to the high neurotoxicity, depression, and anxiety are the most prominent characteristics of methamphetamine (Meth) withdrawal. Studies to date on the issue of Meth-associated depression and anxiety are focused on the brain, however, whether peripheral homeostasis, especially the "microbiota-gut" axis participates in these adverse outcomes, remains poorly understood. In the current study, with the fecal microbiota transplantation (FMT) assay, the mice received microbiota from Meth withdrawal mice displayed marked depression and anxiety behaviors.

-Quinone methides in natural product synthesis: an update.

In recent years, -quinone methides have emerged as indispensable reactive species for enhancing synthetic efficiency in accessing various bioactive natural products. Importantly, the emulation of nature's patterns and strategies has yielded numerous refined synthetic pathways for the construction of intricate molecules. -Quinone methides (-QMs) have demonstrated remarkable versatility in organic synthesis, especially in strategies guided by biomimetic logic.

Workplace Violence Against Chinese Nurses From the Perspectives of Social Media and News Reports: A Multilayer Text Mining Analysis.

Aims: This study compares the emotional expressions and structural characteristics of workplace violence (WPV) against Chinese nurses in social media comments and news reports, highlighting differences and focal points in dissemination.

Design: A quantitative study utilising text mining and social network analysis.

Methods: Data containing the keywords 'nurse violence', 'nurse workplace violence', 'nurse bullying', 'nurse workplace bullying' were collected from social media platforms (e.

Achieving Enhanced Sodium Storage Performance of Hard Carbon via Rational Modification of a Starch Precursor.

Chemical modification of starch hydroxyl groups plays a key role in modulating the microstructures and enhancing the electrochemical performance of the hard carbon (HC) anode in sodium-ion batteries (SIBs). However, the regulation and design of advanced sodium storage structures are limited by their diverse and complex microstructures. Herein, diammonium phosphate (DAP) as a cross-linking agent for corn starch and modification of the physicochemical properties of the starch surface can effectively promote the regulation and balance between the pore structure and interlayer spacing of the constructed HC.

Four noncentrosymmetric molybdophosphates discovered by a chemical substitution strategy.

Herein, four molybdophosphates, ABMoPO (A = Na, K and B = Rb, Cs), were synthesized by cation substitution. Compared with the parent compound AMoPO (A = Rb, Cs), the different cations result in different polarities of the structural-functional unit, ultimately influencing the nonlinear optical properties of ABMoPO ( = 1-4).

A meta-analysis to study the effects and relationships of various selenium sources and forms on production performance, antioxidant status and egg quality of laying hens.

Background: Nowadays, there is increasing interest in optimizing the beneficial effects on egg quality and production by investigating various levels and sources of Se.

Methods: Data of various forms, sources and levels of Se were analyzed using a meta-analysis approach in terms of their effects on production, antioxidant activity and egg Se deposition of laying hens by using 81 peer-reviewed publications.

Results: Overall, laying hens' performance and egg quality attributes were not affected by Se supplementation, except for minor changes in egg weight and eggshell thickness in response to higher Se levels in diets.

Eliminating Radioresistance With a Magnetic Ion-Generator by Simultaneously Augmenting DNA Damage and Diminishing Immunosuppression.

Radiotherapy (RT) hinges on DNA damage-induced cancer cell death and the subsequent anti-tumor immunity. However, the efficacy of RT is curtailed by cell cycle heterogeneity and an immunosuppressive tumor microenvironment, which foster radioresistance. Here an ion generator-based RT enhancement strategy is demonstrated in a mouse model of the radioresistant tumor.

Iodine-131 Combined With Plasma Exchange Treatment in Graves' Hyperthyroidism Patients With Severe Liver Injury Whose Average Model for End-Stage Liver Disease Scores >20.

Background And Aims: The purpose of this retrospective study is to describe the Graves' hyperthyroidism patients with severe liver injury treated by iodine-131 combined with plasma exchange (PE).

Methods: The patients who had hyperthyroidism caused by Graves' disease, with severe liver injury (The level of total bilirubin ≥12 mg/dL), and after 1 week of liver protective medication treatment, the patient's liver function did not improve, were enrolled in this study. All patients were treated with iodine-131 and PE.

Three local plants adapt to ecological restoration of abandoned lead-zinc mines through assembly of rhizosphere bacterial communities.

Introduction: The plant restoration and ecological restoration of lead-zinc mines are very important.

Methods: In this study, we used three local plants to carry out ecological restoration of abandoned lead-zinc mining areas and detected the adaptive mechanisms of soil bacterial diversity and function during the ecological restoration of lead-zinc mines through 16S rRNA sequencing.

Results: The results revealed that lead-zinc mining significantly reduced the soil bacterial diversity, including the Shannon, Simpson, and observed species indices, whereas the planting of the three ecological restoration plants restored the soil microbial diversity to a certain extent, leading to increases in the Shannon index and Observed species indices.

Effects of the stress hormone norepinephrine on the probiotic properties of : antibacterial colonization, anti-inflammation, and antioxidation.

Probiotics as antibiotic alternatives are unstable for use under stress in clinical applications. To explore the influence of catecholamine hormones on probiotic bacterial inhibition and antimicrobial activity, we tested the effects of norepinephrine (NE) on and in a mouse model. The results showed that in the presence of NE, 80% of strains showed increased growth rate and more than 80% of the strains indicated lower antimicrobial activity at 22 h.

iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis.

Background: Cryptococcal meningitis (CM) is a significant global health issue, particularly affecting individuals with HIV. Amphotericin B (AmB) serves as the cornerstone treatment for CM; however, its clinical application is restricted due to limited penetration of the blood-brain barrier and associated nephrotoxicity.

Objective: This study investigates the use of exosomes derived from induced pluripotent stem cells (iPSC-Exos) as carriers for AmB in treating CM, aiming to enhance therapeutic efficacy and safety and reduce AmB toxicity.

Impact of self-efficacy and burnout on professional development of physical education teachers in the digital age: a systematic review.

Background: The professional development of teachers in the digital age will positively impact the effectiveness of physical education teaching. Exploring key factors such as self-efficacy, burnout, and digital technology is crucial to ensure the professional development of teachers.

Methods: The search was conducted in accordance with the PRISMA guidelines and utilized the following databases: Scopus, Web of Science, ProQuest, and Google Scholar.

ENTPD8 overexpression enhances anti-PD-L1 therapy in hepatocellular carcinoma via miR-214-5p inhibition.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, with poor prognosis due to late diagnosis and limited treatment options. In this study, we evaluated the expression of ectonucleoside triphosphate diphosphohydrolase 8 (ENTPD8) in HCC tissues and its clinical significance. Immunohistochemistry, The Cancer Genome Atlas (TCGA) data, and single-cell expression analysis revealed reduced ENTPD8 levels in liver cancer compared to adjacent tissues, with ENTPD8 primarily expressed in tumor cells within the tumor tissue.

The Role of Placental MFF-Mediated Mitochondrial Fission in Gestational Diabetes Mellitus.

Introduction: Gestational diabetes mellitus (GDM) refers to hyperglycemia first recognized during pregnancy, characterized by decreased insulin sensitivity and impaired glucose metabolism. Dynamic fusion and fission processes within mitochondria play critical roles in maintaining glucose metabolism homeostasis. Given the fundamental role of mitochondrial fission factor (MFF) in mitochondrial fission, the intention of this study was to investigate mitochondrial dynamics in the placentae of GDM patients and explore the role of MFF in the etiopathogenesis and progression of GDM through the modulation of glucose metabolism and insulin resistance.