Optimizing phage therapy for carbapenem-resistant bacteremia: insights into dose and timing.

The increase in multidrug-resistant (MDR) complex (ECC) infections, particularly those resistant to carbapenems, underscores the urgent need for alternative therapies. Phage therapy, with its specific bactericidal action, offers a promising solution. However, there remains a shortage of well-characterized ECC-targeting phages, and dosing and timing optimization for ECC-specific phage cocktails is largely unexplored.

Photoredox nickel-catalyzed radical cyclization of -arylacrylamides with alkyl bromides.

3,3-Disubstituted oxindoles constitute a significant class of biologically active molecules, often found in a wide range of bioactive compounds. In this work, we present a photoredox nickel-catalyzed intermolecular cyclization between -arylacrylamides and readily accessible alkyl bromides, which affords a diverse range of 3,3-disubstituted oxindoles in moderate to high yields. Our mechanistic studies reveal that the reduction of alkyl bromides single-electron transfer from a reactive Ni(I) species is a critical step in driving this radical cascade transformation.

Tunable-Emissive Zeolite-Confined Silver Nanoclusters as a Rapid and Highly Sensitive Photoluminescent Sensor for Trace Water Detection in Organic Solvents.

Zeolite-confined silver nanoclusters (AgNCs/Zeolite) are highly promising luminescent materials. Nevertheless, the controlled synthesis of AgNCs/Zeolite composites with tunable luminescent responses remains a persistent challenge. In this study, highly luminescent AgNCs/Zeolite composites are developed through the counter-cations engineering strategy via confining AgNCs within the cages of FAUX with Na and Zn as the counter cations (Ag-FAUX(Na/Zn)), which show water-triggered switchable yellow/green tunable-emissive properties with PLQY up to 90% and high tolerance to chemical reduction.

Protective Effect on Spinal Cord Injury of Prophylactic Cerebrospinal Fluid Drainage in Extensive Aortic Arch Repair for Type A Aortic Dissection: A Retrospective Cohort Study.

Background: Cerebrospinal fluid drainage (CSFD) is commonly used to manage spinal cord injury (SCI) after aortic surgery. However, there is still limited evidence regarding its effectiveness in patients with type A aortic dissection undergoing total arch replacement plus frozen elephant trunk procedure.

Methods: A total of 1931 patients were retrospectively enrolled between 2010 and 2023.

Proteome-Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease.

Objective: To identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset and progression of Parkinson's disease (PD) through integrative proteomic and genetic analyses.

Method: We utilized large-scale plasma and brain protein quantitative trait loci (pQTL) datasets from the deCODE Health study and the Religious Orders Study/Rush Memory and Aging Project (ROS/MAP), respectively. Proteome-wide association studies (PWAS) were conducted using the OTTERS framework for plasma proteins and the FUSION tool for brain proteins, examining associations with PD onset and three progression phenotypes: composite, motor, and cognitive.

The effect of auditory rhythm on the temporal allocation of visual attention in aging.

Introduction: Isochronous rhythm has been shown to induce temporal expectation, allocated attention to specific points in time to optimize behavioral performance, both within a single modality and across different modalities, in younger adults. However, it remains unclear how an isochronous rhythm in one modality influences the temporal allocation of attention in another modality among older adults. Moreover, whether the cross-modal temporal expectation effect in aging is influenced by tempo has not yet been explored.

The Diminished Cardiorespiratory Fitness in Cardiovascular-Kidney-Metabolic Syndrome.

Objective: The American Heart Association has recently emphasized the significance of the cardiovascular-kidney-metabolic (CKM) syndrome. However, the cumulative impact of these factors on cardiorespiratory fitness remains inadequately characterized. This study aimed to examine the responses observed during cardiopulmonary exercise testing (CPET) of CKM syndrome patients and explore the potential correlation between cardiorespiratory fitness and hemoglobin concentration in this cohort.

A study on the differences in the gut microbiota and metabolism between male and female mice in different stress periods.

The sex difference in depression has long been an unsolved issue. Women are twice as likely to suffer from depression as men. However, there were significant differences in the composition of gut microbiota between women and men.

Profile of STING agonist and inhibitor research: a bibliometric analysis.

Background: STING is a core signaling hub molecule in the innate immune system, involved in various diseases, including infectious diseases, autoimmune diseases, tumors, aging, organ fibrosis, and neurodegenerative diseases. Its activation has shown great potential in anti-tumor and anti-infective therapies, with STING agonists emerging as a promising approach in cancer immunotherapy in recent years. This study identifies research trends and potential directions in the field by collecting and analyzing relevant literature.

The occurrence of wheat crown rot correlates with the microbial community and function in rhizosphere soil.

Wheat crown rot (WCR) is a significant soil-borne disease affecting wheat production worldwide. Understanding the impact of wheat crown rot on the structure and function of microbial communities in the wheat rhizosphere soil can provide a theoretical basis for the mining biological control resources against WCR. In this study, rhizosphere soils with varying WCR severities (light, moderate, severe) were analyzed for chemical properties, microbial community composition and functions using high-throughput sequencing.

Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive.

Male breast cancer is a rare neoplasm, accounting for approximately 1% of all breast cancer cases. It typically presents as a painless, retroareolar mass. An exceedingly rare variant is male occult breast cancer, which is primarily characterized by axillary lymph node enlargement without an identifiable primary breast tumor.

Primary leiomyosarcoma of the scalp: a case report and review of the literature.

Background And Importance: Leiomyosarcoma is a rare and aggressive malignant tumor with a high potential for relapse and metastasis. Correct and timely diagnosis is critical for effective treatment, yet it is often challenging due to the diverse clinical presentations. This case report highlights the significance of early identification and the consequences of delayed diagnosis in scalp leiomyosarcoma.

The impact of China's low-carbon policies' intensity on the labor demand of listed companies.

This study examines the impact of China's low-carbon policies on labor demand in listed firms, focusing on command-and-control and market-based instruments. The research integrates a comprehensive dataset spanning 2007 to 2016, comprising employment and financial data, alongside an analysis of low-carbon policy intensity from 2007 to 2022. Results from fixed-effects panel data regression indicate that both types of policies positively influence labor demand, with command-and-control policies exhibiting a slightly stronger effect.

Pan-genome analysis and expression verification of the maize ARF gene family.

Auxin transcription factors regulate auxin responses and play crucial roles in plant growth, development, and responses to abiotic stress. Utilizing the maize pan-genome data, this study identified 35 ARF family members in maize, comprising 21 core genes, 10 near-core genes, and 4 non-essential genes; no private genes were detected. The construction of a phylogenetic tree using Arabidopsis thaliana revealed that the G3 subfamily comprises the highest number of core genes, with a total of 10, and exhibits relative stability throughout the evolution of maize.

Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic.

The oral microbiome comprises over 700 distinct species, forming complex biofilms essential for maintaining oral and systemic health. When the microbial homeostasis in the periodontium is disrupted, pathogens within the biofilm can cause periodontitis and peri-implantitis, inducing host immune responses. Understanding the role of microbial communities and the immune mechanisms in oral health and disease is crucial for developing improved preventive, diagnostic and therapeutic strategies.

Effect of high-voltage electrostatic field salting on the quality of salt-reduced Yi ye Cheng golden pomfret.

This study investigates the effect of high-voltage electrostatic field (HVEF) salting on the quality of salt-reduced Yi Ye Cheng golden pomfret. Results showed that the salt content increased with the voltage ( < 0.05).

Clinical Indicator Analysis: Unraveling the Distinct Clinical Characteristics of Kümmell's Disease Compared to Osteoporotic Vertebral Compression Fractures.

Study Design: Retrospective case-control study.

Objective: To examine the differences in various clinical indicators between Kümmell's disease (KD) and osteoporotic vertebral compression fractures (OVCF), in order to assist in the diagnosis of KD and provide a foundation for further analysis of its risk factors.

Summary Of Background Data: The mechanisms underlying the progression of OVCF to KD remain unclear, and research analyzing the indicators between the two conditions is still limited.

Arabidopsis bHLH60 can regulate leaf development by interacting with and counteracting the AS1-AS2 complex to affect BP1 expression.

During leaf morphogenesis, various factors interplay to mediate abaxial-adaxial and proximal-distal polarity, along with other factors contributing to organ boundary and leaf expansion. Although significant progress has been made in understanding the genetics of leaf development, there are still gaps in our understanding of leaf morphogenesis. Here, we show that the bHLH60 transcription factor can affect leaf development.

Prenylation of flavonoids by DMATS1 and their anti-inflammatory activities.

Background: Prenylated flavonoids are widely distributed in plants, including fruits and vegetables in the Moraceae and Fabaceae families. These chemicals are potential functional food ingredients owing to their attractive biological activities. However, natural prenylated flavonoids are rare, which limits their application.

Microplastics and nanoplastics increase major adverse cardiac events in patients with myocardial infarction.

Microplastics and nanoplastics (MNPs) have implicated in cardiovascular disease in preclinical studies. Our objective is to investigate the relationship between MNPs in the coronary arteries and major adverse cardiac events (MACE) in patients with myocardial infarction (MI).We conducted a prospective observational study involving patients undergoing coronary angiography for MI.

[Respiratory sleep monitoring and sleep quality questionnaire survey of Class Ⅱ malocclusion adolescents before and after functional orthodontic treatment].

Purpose: To compare the changes of sleep-breathing parameters and sleep quality before and after treatment of Class Ⅱ malocclusion in adolescents.

Methods: Forty-eight adolescent patients were selected for functional orthodontic treatment. Portable sleep breathing monitor and Pittsburgh sleep quality index(PSQI) were used before treatment, 1 month and 10 months after treatment, in order to compare the results of apnea and hypopnea index(AHI), obstructive apnea index(OAI), central apnea index(CAI), number of hypoventilation (HI), oxygen reduction index (ODI), minimum oxygen index(LSpO) and sleep quality index.

[Analysis of the diagnostic value of X-ray and CBCT 3D reconstruction in adolescent orthodontic patients with impacted teeth].

Purpose: To evaluate the value of X-ray and cone-beam CT(CBCT) three-dimensional reconstruction in the diagnosis of impacted teeth in adolescent orthodontic patients.

Methods: From May 2021 to May 2024, totally 86 adolescent orthodontic patients with 126 impacted teeth admitted to the Second Hospital of Baoding City were selected for X-ray examination and CBCT 3D reconstruction. The diagnostic efficiency and accuracy of the two methods were evaluated by comparing their ability to reveal the location and adjacent anatomical structures of the impacted teeth.

Engineering topological phases in transition-metal-doped penta-hexa-graphene: towards spintronics applications.

The roles of Pd and Pt doping in penta-hexa-graphene (PH-G) were studied using first principles DFT calculations, which may lead to a better understanding of the dopant effects and further help to expand the application potential of PH-G. We find that doping could significantly change the basic properties in PH-CX (X = Pd, Pt). Compared to PH-G, doping transforms these materials from semiconductors into conductors, resulting in the emergence of Dirac points near the Fermi level.

LATERAL FLORET 2 encoding a sucrose non-fermenting 2 chromatin remodeling factor regulates axillary meristem of spikelet development in rice (Oryza sativa).

The spikelet, a unique inflorescence unit of grasses such as rice (Oryza sativa), possesses developmental regulatory mechanisms that require further exploration. In this study, we identified a mutant named lateral floret2 (lf2), which exhibited abnormalities in spikelet development. The lf2 mutants produced lateral florets within the axils of sterile lemmas and/or lateral spikelets within the axils of rudimentary glumes.

Pan-Cancer Analysis Reveals SKA3 as a Potential Diagnostic and Prognostic Biomarker.

SKA3, an important factor in cell cycle regulation, is involved in spindle assembly and kinetochore function, playing a critical role in maintaining cancer cell proliferation and division. However, its specific roles and regulatory mechanisms in cancer remain not fully understood. Large-scale datasets from multiple public databases, including The Cancer Genome Atlas and Genotype-Tissue Expression, covering various cancer types, were integrated.