Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer.

High mobility group A1 (HMGA1) is a class of non-histone chromosomal protein and is highly expressed in the embryonic period and many tumors. It is involved in multiple hallmarks of tumors and affects the occurrence and progression of tumors. Nowadays, many non-coding RNAs (ncRNAs), such as miRNA, lncRNA, and circRNA, have been found to play a crucial role in HMGA1 regulation.

The impact of digital literacy on the health behavior of rural older adults: evidence from China.

Background: To understand the impact of digital literacy on the health behavior of rural older adults in China, and to provide policy basis and intervention measures for improving their health behavior.

Methods: This study utilizes data from 1207 rural older adults aged 60 and above in the 2020 China Rural Revitalization Survey (CRRS), employing the Ordered Probit model and instrumental variable analysis to assesses the impact of digital literacy on the health behavior of rural older adults in China. Furthermore, the study examines the mediating effects of happiness and future expectations and analyses the differences in the impact of digital literacy across dimensions such as age, gender, and physical health status.

Red blood cell distribution width to albumin ratio (RAR) is associated with low cognitive performance in American older adults: NHANES 2011-2014.

Background: The red blood cell distribution width to albumin ratio (RAR) is a novel comprehensive biomarker of inflammation and nutrition, which has emerged as a reliable prognostic indicator for adverse outcomes and mortality in patients with various diseases. However, the association between RAR and low cognitive performance in older adults remains unclear. This study aims to investigate the relationship between RAR and low cognitive performance among older adults in the United States.

Relationship between cognitive impairments and psychopathological symptoms in female schizophrenia subsequent to 8 weeks treatment with antipsychotic drugs.

Background: Changes in cognitive impairments and their relationship with psychopathological symptoms during treatment in schizophrenia remain debatable. Especially, there is few studies specifically focusing on female patients. Further exploration of the characteristics of female schizophrenia patients can offer valuable sex-related considerations for clinicians in diagnosis and interventions.

CNPY3's regulation of tumor microenvironment and its impact on colon cancer aggressiveness.

Background: Canopy FGF signaling regulator 3 (CNPY3) has been implicated in tumor progression. However, its specific role in colon cancer (CC) remains unclear. This study aims to investigate the function of CNPY3 in CC and its potential as a therapeutic target.

Association of visceral adiposity index (VAI) with prognosis in patients with metabolic syndrome and heart failure with reduced ejection fraction.

Background: Visceral Adiposity Index (VAI) is an effective predictor of metabolic syndrome (MetS) and serves as a marker of visceral adiposity. The association between the VAI index and poor prognosis in patients with MetS and Heart failure with reduced ejection fraction (HFrEF) remains unclear. The aim of this study is to evaluate the relationship between VAI and endpoint events in patients with metabolic syndrome and HFrEF.

Vapour-liquid-solid-solid growth of two-dimensional non-layered β-BiO crystals with high hole mobility.

Currently, p-type two-dimensional (2D) materials lag behind n-type ones in both quantity and performance, hindering their use in advanced p-channel transistors and complementary logic circuits. Non-layered materials, which make up 95% of crystal structures, hold the potential for superior p-type 2D materials but remain challenging to synthesize. Here we show a vapour-liquid-solid-solid growth of atomically thin (<1 nm), high-quality, non-layered 2D β-BiO crystals on a SiO/Si substrate.

Red teaming ChatGPT in medicine to yield real-world insights on model behavior.

Red teaming, the practice of adversarially exposing unexpected or undesired model behaviors, is critical towards improving equity and accuracy of large language models, but non-model creator-affiliated red teaming is scant in healthcare. We convened teams of clinicians, medical and engineering students, and technical professionals (80 participants total) to stress-test models with real-world clinical cases and categorize inappropriate responses along axes of safety, privacy, hallucinations/accuracy, and bias. Six medically-trained reviewers re-analyzed prompt-response pairs and added qualitative annotations.

STAT1 mediates the pro-inflammatory role of GBP5 in colitis.

Previous studies establish guanylate binding protein 5 (GBP5) as a driver in the development of inflammatory bowel diseases (IBDs). Here, we aim to elucidate the mechanism underlying the pro-inflammatory role of GBP5. We observe that loss of Gbp5 causes reduced colonic inflammation and decreased numbers of innate lymphoid cells (ILCs) in colitis mice.

Spectroscopic and molecular docking studies on binding interactions of camptothecin drugs with bovine serum albumin.

This study investigates the binding interactions between bovine serum albumin (BSA) and camptothecin (CPT) drugs (camptothecin, 10-hydroxycamptothecin, topotecan, and irinotecan) using UV-Vis spectroscopy, fluorescence spectroscopy, three-dimensional fluorescence spectroscopy, and molecular docking techniques. The fluorescence quenching of BSA by CPT drugs follows a static mechanism, with binding constants (K) ranging from 4.23 × 10 M (CPT) to 101.

Diversity of intestinal microbiota and inflammatory cytokines after severe trauma.

Accumulating evidence has reported that the intestinal microbiota could play important roles in the occurrence and progression of severe trauma. However, the hypothesized potential targeted intestinal microbiota to mediate and regulate the levels of inflammatory cytokines and promote rapid recovery of body after severe trauma remains unclear. This study was aimed to explore the changes and correlation of intestinal microbiota and inflammatory cytokines in rats with severe crush and fracture trauma.

Hyperspectral estimation of chlorophyll content in grapevine based on feature selection and GA-BP.

Leaf chlorophyll content (LCC) is a key indicator for assessing the growth of grapes. Hyperspectral techniques have been applied to LCC research. However, quantitative prediction of grape LCC using this technique remains challenging due to baseline drift, spectral peak overlap, and ambiguity in the sensitive spectral range.

Parvimonas micra promotes oral squamous cell carcinoma metastasis through TmpC-CKAP4 axis.

Parvimonas micra (P. micra), an opportunistic oral pathogen associated with multiple cancers, has limited research on its role in oral squamous cell carcinoma (OSCC). This study shows that P.

Causal associations between Sarcopenia-related traits and obstructive sleep apnea: a mendelian randomization study.

Background: Evidence for a causal relationship between sarcopenia and obstructive sleep apnea (OSA) is scarce. This study aimed to investigate the causal association between sarcopenia-related traits and OSA utilizing Mendelian randomization (MR) analyses.

Methods: MR analyses were conducted using genetic instruments for sarcopenia-related traits, including hand grip strength, muscle mass, fat mass, water mass, and physical performance.

Short-term outcomes of extracorporeal versus intracorporeal side-to-side anastomosis after laparoscopic right hemicolectomy for colon cancer: an affiliated study of a multicenter snapshot study.

Background: Laparoscopic right hemicolectomy (RHC) is the primary surgical approach for right-sided colon cancer. Different ileo-colonic anastomosis techniques may lead to varied postoperative outcomes. This study aims to compare intracorporeal versus extracorporeal side-to-side anastomosis post laparoscopic RHC for short-term outcomes in right-sided colon cancer patients.

Long-Term Clinical Outcomes of the Transcatheter Aortic Valve System for Aortic Valve Stenosis.

Objective: To evaluate the clinical safety and efficacy of the self-expanding transcatheter aortic valve system in Chinese patients with severe aortic stenosis (AS) during follow-up.

Study Design: Observational study. Place and Duration of the Study: Department of Cardiology, Yulin First People's Hospital, The Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi, China, from April 2020 to September 2022.

Enantioselective Acylation of Benzylic C(sp3)-H Bond Enabled by a Cooperative Photoredox and N-Heterocyclic Carbene Catalysis.

Organocatalyzed direct and asymmetric functionalization of benzylic C(sp3)-H bond is attractive yet challenging. Herein, we report the enantioselective acylation of benzylic C(sp3)-H bond via a cooperative photoredox and N-heterocyclic carbene (NHC) catalysis, affording the corresponding chiral α-aryl ketones in moderate to good yields with good to excellent enantioselectivities (up to 99:1 er). The rational design of novel NHCs guided by initial evaluation of available catalysts and their application promote the asymmetric transformation.

Whole transcriptome sequencing-based identification and functional prediction of salt-tolerant-related circular RNAs in ZM-4 (Malus zumi).

CircRNAs, are a class of covalently closed non-coding RNAs; they have been identified in many plants and play an important role in the response to abiotic stresses. However, little is known about the response of the circRNAs of salt-tolerant apple rootstock resources in response to salt stress. In this study, the leaves and roots of the salt-tolerant Malus resource, ZM-4, and the salt-sensitive rootstock M9T337, were used as test materials and were exposed to 75 mmol/L NaCl stress for 0 h and 24 h.

The mitochondrial protease ClpP is a promising target for multiple myeloma treatment.

Drug resistance and relapse are the major obstacles in multiple myeloma (MM) treatment, driving the search for novel therapeutics. The chemoactivation of mitochondrial caseinolytic protease P (ClpP) has shown to have anticancer effects on many tumors, but has seldom been elucidated in MM. Here we found that the CLPP expression was elevated in MM patients, and further increased in relapsed cases.

Effects of a protein kinase C epsilon inhibitor on insulin signalling in lipid-treated HepG2 hepatocytes and glucose tolerance in fat-fed mice.

Aims: Protein kinase C epsilon (PKCε) plays a causative role in the development of glucose intolerance, and is a potential target for the treatment of type 2 diabetes. Here, we examined the effects of the PKCε inhibitor CIDD-0150612 (CP612) on insulin action in palmitate-treated HepG2 hepatocytes in vitro and on glucose homeostasis in fat-fed mice in vivo.

Methods: HepG2 cells were treated with palmitate and CP612 and stimulated with insulin.

Cullin3 mitigates NEFA-induced oxidative stress in mammary epithelial cells: involvement of BCL2/BECN1 and autophagy.

High nonesterified fatty acid (NEFA) concentrations in cows with clinical ketosis lead to metabolic dysfunction in mammary cells, resulting in oxidative stress. Studies have shown that autophagy is impaired in the mammary glands of ketotic cows, while enhancing autophagy mitigate oxidative stress in these animals. Cullin3 (CUL3), an E3 ubiquitin ligase, is integral for maintaining cellular homeostasis, particularly regulation of oxidative stress and autophagy.

Increased Circulating Apolipoprotein Cs Are Implicated in the Association Between Elevated Serum Retinol and Retinol-Binding Protein 4 and Adverse Progression of Metabolic Syndrome in Adults: A Prospective Study.

Prior research has highlighted the significant roles of circulating retinol, retinol-binding protein 4 (RBP4), and apolipoprotein C (ApoC) in metabolic health. This study investigates the joint association of retinol and RBP4 with metabolic syndrome (MetS) and examines the potential mediating role of ApoCs in these relationships. This prospective study included 3009 and 2724 participants with baseline serum retinol and RBP4 data, respectively.

Naringenin alleviates heat stress-induced liver injury in Ningdu yellow chickens by decreasing RIPK3 and PDC binding.

Naringenin, a flavonoid extract, possesses anti-inflammatory, antioxidant, hepatoprotective, antitumor, and antineurotoxic properties. This study investigated the anti-heat stress effects in broilers by adding 200mg/kg naringenin to the diet of Ningdu yellow chicken under heat stress conditions. Heat stress conditions was controlled at 37 ± 2°C (7:00 a.