Hypoxia-preconditioned human dental pulp stem cells transplantation alleviates hypoxic-ischemic brain damage via STAT3/NLRP3/Caspase-1 axis in neonatal rats.

This study was conducted to examine the effects and mechanisms of hypoxia-preconditioned human dental pulp stem cells (H-hDPSCs) transplantation on microglial pyroptosis in neonatal rats with hypoxic-ischemic brain damage (HIBD). The hDPSCs were extracted using the tissue block method and identified by immunofluorescence staining. The HIBD model was constructed using the classical Rice-Vannucci method.

Tumor immune microenvironment of colorectal cancer identifies novel prognostic signature and potential therapeutic drugs.

The tumor microenvironment (TME) is increasingly recognized as a key player in colorectal cancer biology, however, its potential for improving diagnosis, prognosis, and treatment remains unclear. The major aim of this study is to explore the prognostic value of TME related gene in colorectal cancer. Expression matrices and clinical data of colorectal cancer obtained from public databases were divided into TME relevant clusters according to immune characterization.

A multi-model machine learning framework for breast cancer risk stratification using clinical and imaging data.

Purpose: This study presents a comprehensive machine learning framework for assessing breast cancer malignancy by integrating clinical features with imaging features derived from deep learning.

Methods: The dataset included 1668 patients with documented breast lesions, incorporating clinical data (e.g.

Quantitative elemental sensitive imaging based on K-edge subtraction tomography.

Background: K-edge subtraction (KES) tomography has been extensively utilized in the field of elemental sensitive imaging due to its high spatial resolution, rapid acquisition, and three-dimensional (3D) imaging capabilities. However, previous studies have primarily focused on the qualitative analysis of element contents, rather than quantitative assessment.

Objective: The current study proposes a novel method for quantitative elemental analysis based on K-edge subtraction tomography.

Novel PKD1 Mutation (c.G10086T) Drives High Intracranial Aneurysm Risk in Autosomal Dominant Polycystic Kidney Disease.

Background: Autosomal dominant polycystic kidney disease (ADPKD) is frequently complicated by intracranial aneurysms (IAs). However, the genetic factors driving the elevated IA risk in ADPKD remain poorly understood. In this study, we identified a novel PKD1 mutation associated with a remarkably high IA incidence in a large Chinese ADPKD family.

Correction: D-A-D organic fluorescent probes for NIR-II fluorescence imaging and efficient photothermal therapy of breast cancer.

Correction for 'D-A-D organic fluorescent probes for NIR-II fluorescence imaging and efficient photothermal therapy of breast cancer' by Jie Gao , , 2024, , 1320-1331, https://doi.org/10.1039/D3BM01604H.

Indirect comparison of the relative vaccine effectiveness of mRNA-1283 vs. BNT162b2 vaccines against symptomatic COVID-19 among US adults.

Background: COVID-19 continues to pose a significant health burden, particularly among older adults. mRNA-1283 is a next-generation COVID-19 mRNA vaccine developed to enhance immune response. Findings from the Phase 3 NextCOVE trial comparing bivalent versions of mRNA-1273 and mRNA-1283 vaccines have recently become available.

Whole-genome sequencing reveals genetic architecture and selection signatures of Kazakh cattle.

Local cattle breeds play a critical role in breeding programs due to their genetic adaptations to diverse environmental conditions. However, the genomic architecture of local cattle breeds in Kazakhstan remains largely unexplored. This study utilized whole-genome sequencing data from Kazakh cattle to elucidate their genetic composition, uncovering three primary ancestral components: European, Eurasian, and East Asian taurine.

Thermally Activated Delayed Fluorescence of Organic-Inorganic Hybrid Menshutkin-Type Cu-Sb Halides.

Organic-inorganic hybrid metal halides have attracted much attention due to their excellent optoelectronic properties. The heterometallic structure is expected to achieve more complex luminescence centers, thereby improving the tunability of the fluorescent materials. This paper reports the synthesis of crystals [Cu(2,2'-bpy)(PPh)][CuCl(PPh)SbOCl] (, 2,2'-bpy = 2,2'-bipyridine, PPh = triphenylphosphine) and (Mim)[SbOCl] (, Mim = 1-methylimidazole).

Pilot randomized controlled trial of extracorporeal shock wave therapy for temporomandibular joint disorders.

Background: Temporomandibular joint disorders (TMDs) are collective terms for a series of clinical diseases. However, due to the complexity of the temporomandibular joint (TMJ), TMDs are still unknown as to their pathogenesis.

Objective: This pilot randomized controlled trial aimed to evaluate the efficacy of extracorporeal shock wave therapy (ESWT) in conjunction with drug therapy for myogenic TMDs

Methods: In accordance with the CONSORT (Consolidated Standards of Reporting Trials) guidelines, we conducted a randomized controlled trial involving 60 patients diagnosed with myogenic TMDs.

Stress granules as transient reservoirs for autophagy proteins: a key mechanism for plant recovery from heat stress.

Stress granules (SGs) are transient, non-membrane-bound cytoplasmic condensates that form in response to environmental stresses, serving as protective reservoirs for mRNAs and proteins. In plants, SGs play a crucial role in stress adaptation, but their relationship with macroautophagy/autophagy, a key process for degrading damaged organelles and misfolded proteins, remains poorly understood. In a recent study, we revealed that key autophagy proteins, including components of the ATG1-ATG13 kinase complex, the class III phosphatidylinositol 3-kinase (PtdIns3K) complex, and the ATG8-PE system, translocate to SGs during heat stress (HS) in .

The Effect of Backscatter Anisotropy in Assessing Hepatic Steatosis Using Ultrasound Hepatorenal Index.

Objectives: To discuss challenges in assessing hepatic steatosis using ultrasound hepatorenal index (HRI).

Methods: We retrospectively analyzed HRI and liver magnetic resonance imaging-based proton density fat fraction (MRI-PDFF) in 134 adult participants (53 men and 81 women, mean age 55 years). The diagnostic performance of HRI for determining hepatic steatosis was tested by the area under the receiver operating characteristic curve (AUROC) using liver MRI-PDFF as the reference.

Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial.

Objective: Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic measures, and metabolic flexibility.

Methods: In this 12-week randomized-controlled trial, we measured weight (primary outcome), body composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), caloric intake (24-h recall), metabolic flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), and glycemic measures (hemoglobin A1c, hyperinsulinemic-euglycemic clamp, continuous glucose monitoring).

Prediction model for sleep disorders in patients transferred out of ICU: Development and validation.

Background: Sleep disturbance is one of the clinical manifestations of post-intensive care syndrome (PICS) in ICU. Sleep disorders can cause changes in patients' emotional, cognitive, memory, immune, and motor systems, resulting in delayed wound healing, increased infection rate, readmission rate, mortality rate and complication rate. However, developing prediction models for sleep disorders in post-ICU patients is an understudied problem.

α-separable graph Hamiltonian network: A robust model for learning particle interactions in lattice systems.

We propose an α-separable graph Hamiltonian network (α-SGHN) that reveals complex interaction patterns between particles in lattice systems. Utilizing trajectory data, α-SGHN infers potential interactions without prior knowledge about particle coupling, overcoming the limitations of traditional graph neural networks that require predefined links. Furthermore, α-SGHN preserves all conservation laws during trajectory prediction.

Extended chemical picture of ionization balance to extremely dense plasmas.

Understanding the ionization balance of extremely dense plasmas still remains a scientific challenge for both theory and experiment, which is very important in many research fields such as the equation of state, radiative opacity, and thermal and electrical conductivities. In a most recent experiment at the National Ignition Facility, the onset of pressure-driven K-shell delocalization was observed in hot dense Be plasmas [T. Döppner et al.

Structure of random Turing-like patterns in discrete-time systems is determined by the initial conditions.

Patterns, spatiotemporal ordered structures, are prevalent in diverse systems, arising from the emergence of complexity. Turing proposed a mechanism that involves a short-range activator and a long-range inhibitor to explain the formation of patterns, and patterns that satisfy this mechanism are called Turing patterns. Patterns with similar structures but not caused by the Turing mechanism are referred to as Turing-like patterns.

Theoretical studies on M-shell relocalization of K-hole Mg ions produced by x-ray free-electron laser.

In hot dense plasmas, orbital delocalization and relocalization considerably influence the ionization balance, equation of state and radiative properties of matter. A self-consistent plasma screening potential is applied in atomic structure calculations for solid-density Mg plasmas, generated by an x-ray free electron laser (XFEL). As the charge state increases, the M-shell orbitals of K-hole Mg ions gradually relocalize, beginning with Mg^{6+} at solid density.

Heat capacity and relaxation dynamics of glassy films: A lattice model study.

We study the calorimetric properties and structural relaxation of glassy films using a distinguishable particle lattice model (DPLM). We determine the glass transition temperature versus film thickness from the heat capacity during heating as well as from the local relaxation time. The results based on both approaches are in good agreement with the experimentally observed Keddie-Cory-Jones relation.

Functional dissection of three pollen-side quantitative trait loci against multiple stylar unilateral incompatibility mechanisms in Solanum pennellii LA0716.

In Solanum pennellii LA0716, three stylar UI (sui) factors and one pollen UI (pui) factor were shown to be involved in S-RNase-independent unilateral incompatibility (UI). However, additional pui factor(s) and the antagonistic relationships among pui and sui factors remain to be investigated. Quantitative trait loci (QTL) mapping, functional and genetic analysis of LA0716-based crosses, and integrated multi-omics data are used to identify pui QTLs and functionally dissect pui QTLs from various types of stylar UI.

Effect and prognosis of thoracolumbar fracture combined with incomplete spinal cord injury on male sexual function.

Background And Purpose: Severe thoracolumbar fractures are associated with spinal cord injury that potentially leads to sexual dysfunction. Our purpose is to study the factors that influence sexual dysfunction and its prognosis.

Methods: This study included 117 male patients with thoracolumbar fractures and incomplete spinal cord injury.

Association of insulin resistance surrogates with disease severity and adverse outcomes in chronic thromboembolic pulmonary hypertension: a multicenter cohort study.

Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a severely progressive disease that leads to right heart failure and death. Previous studies have shown that diabetes and insulin resistance (IR) are closely related to pulmonary hypertension, but the role of IR in patients with CTEPH remains unexplored. In this study, we investigated the relationship between four insulin resistance indices and disease severity, hemodynamic parameters, and adverse outcomes in patients with CTEPH.

Identification and pathogenicity of avian hepatitis E virus from quail.

Background: Avian hepatitis E virus (HEV) has caused economic losses in the poultry industry and has shown a broad spectrum of infections. In 2022, a quail farm (YangLing, China) exhibited a decrease in egg production, an increase in mortality and hepatosplenomegaly. These characteristics were similar to those of avian HEV infection.

Association of body roundness index with cardiovascular disease and all-cause mortality among Chinese adults.

Aims: To determine the impact of body roundness index (BRI) on the 10-year risk of cardiovascular disease (CVD) and all-cause mortality in Chinese adults.

Materials And Methods: We utilized data from a nationwide prospective cohort of 165 785 Chinese adults (aged ≥40 years, free of CVD and cancer at baseline), which was extracted from the China Cardiometabolic Disease and Cancer Cohort (4C). Cox regression and restricted cubic splines quantified BRI-outcome associations and identified optimal BRI cutoffs.