Thermodynamics and kinetics of lithiation-induced phase transitions in nanoporous antimony.

The impact of nanosizing on the phase transition mechanisms of electrode materials is still not well understood. In this study, we reveal that nanosizing can lower the energy barrier and entropy changes associated with phase transformations, ultimately improving the electrochemical performance of nanoporous antimony electrodes in comparison to microsized antimony.

Cumulative blood pressure predicts risk of cardiovascular outcomes in middle-aged and older population.

Background: Cardiovascular disease (CVD) remains a major health concern globally, contributing to a considerable disease burden. However, few studies have considered long-term cumulative blood pressure (cBP) exposure in middle-aged and older population in China. The aim of this study was to investigate whether long-term cBP was associated with subsequent cardiovascular outcomes among participants without CVD at baseline in Chinese over 45 years old.

METTL7A as a New Candidate Biomarker in Gastric Cancer by Genomics and Data-Independent Acquisition Proteomic Analysis.

Background: Early diagnosis and intervention are essential for improving the prognosis and survival of gastric cancer (GC) patients. However, specific biomarkers for early GC diagnosis are still unavailable.

Methods: Data-independent acquisition (DIA) proteomics was employed to identify differentially expressed proteins (DEPs) between GC and adjacent non-tumor tissues.

Quantitative Detection of Orthotopic Liver Cancer in Mice Using Indocyanine Green and Dynamic Diffuse Fluorescence Tomography Imaging.

Orthotopic tumor model has become an essential tool for studying drug biodistribution and tumor progression over time owing to the rapid development of in vivo imaging and immunological science. Dynamic diffuse fluorescence tomography (DFT) is a promising imaging modality that can map the three-dimensional distribution of a fluorophore within the object and capture the metabolic parameters of fluorophores in vivo. It has been widely applied in tumor detection, drug development, and efficacy evaluation.

Architecting of All-Cellulose-Based Wicking Fabric for a Large-Scale, Low-Cost, and Highly Efficient Solar Desalination Evaporator.

Interfacial solar vapor generation (ISVG) technology has been considered a promising and sustainable strategy for seawater desalination and wastewater treatment. However, its practical application is greatly limited due to severe salt accumulation and poor long-term evaporation stability. Herein, an all-cellulose-based wicking fabric (CB@CA/CF) is fabricated via a breath figure template (BFT) method for high-performance and stable desalination.

Case Report: Complete response to four cycles of camrelizumab in a PD-L1 negative patient with advanced oral squamous cancer.

Immunotherapy has brought better survival benefits in the treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, owing to the lack of relevant biomarkers that could predict the efficacy of this treatment, it often has to be maintained. Here we report on a patient with stage IVA squamous cell carcinoma of the tongue who developed an unresectable lesion in the neck after surgery and radical chemoradiotherapy.

Intraprocedural activated clotting time and heparin dosage in pulsed field ablation of paroxysmal atrial fibrillation.

Aims: Whether the intraprocedural anticoagulation regimen and activated clotting time (ACT) in pulsed field ablation (PFA) for atrial fibrillation (AF) are the same as those for radiofrequency catheter ablation (RFCA) is currently unknown.

Methods And Results: Our retrospective study included 51 paroxysmal AF patients who underwent PFA (PFA group) and were matched with paroxysmal AF patients who underwent RFCA. Nearest-neighbor propensity score matching was performed at a 1:1 ratio (no tolerance to anticoagulant regimens and a tolerance of 0.

Gold complex QB1561 suppresses drug-resistant cancer cells by inhibiting TrxR and mitochondrial respiratory function.

Introduction: Multi-drug resistance (MDR) is one of the leading reasons that cause the failures of cancer treatment. Novel agents that may reverse MDR and neutralize drug-resistant cancer cells are highly desirable for clinical practice. The targeting of cellular redox homeostasis and/or mitochondria-mediated energy metabolism are promising strategies for the suppression of drug-resistant cancer cells.

Shuhe granule for insomnia: study protocol for a double-blind, randomized, placebo-controlled trial.

Introduction: Modern medical treatment of insomnia is often associated with issues like addiction, drug resistance, and a high risk of relapse post drug withdrawal. To tackle these challenges, the Chinese medicine formula Shuhe granule (SHG) has been employed in insomnia treatment at Guangdong Provincial Hospital of Chinese Medicine. Despite this, there is currently a lack of reliable evidence from evidence-based trials to support the widespread use of SHG in insomnia treatment.

Optimizing Triple-Negative Breast Cancer Therapy via Ultrasound-Enhanced Piezocatalysis for Targeted Chemodrug Release.

Introduction: Triple-negative breast cancer (TNBC) is known for its high malignancy, limited clinical treatment options, and poor chemotherapy outcomes. Although some advancements have been made using nanotechnology-based chemotherapy for TNBC treatment, the controlled and on-demand release of chemotherapeutic drugs at the tumor site remains a challenge.

Methods: We manufactured DOX/BaTiO@cRGD-Lip (DBRL) nanoparticles as an ultrasound (US)-controlled release platform targeting the delivery of Doxorubicin (DOX) for TNBC treatment.

Bibliometric and visual analysis in the field of electroacupuncture's analgesia and regulation on negative emotion from 2014 to 2024.

Introduction: This bibliometric study systematically analyzes the research landscape of electroacupuncture (EA), focusing on its applications in pain relief and emotional regulation from 2014 to 2024. EA, a contemporary adaptation of traditional acupuncture, has gained significant attention for its potential therapeutic benefits in managing chronic pain and mood disorders.

Methods: Using the Web of Science Core Collection as the primary data source, we identified 537 articles related to EA's therapeutic effects.

Long-term straw return with moderate nitrogen levels reshapes soil communities in a vertisol.

Introduction: Incorporating straw into the soil is a sustainable practice that can mitigate some of the adverse effects of excessive N fertilization on soil structure degradation and microbial diversity reduction.

Methods: This objective of this study was to determine the combined effects of straw management (straw return and straw removal) and N fertilization (0, 360, 450, 540, 630, and 720 kg N ha yr.) on crop yields, soil properties, and soil microbial communities in a long-term wheat-maize cropping system.

Targeting Non-Eosinophilic Immunological Pathways in COPD and AECOPD: Current Insights and Therapeutic Strategies.

COPD is a multifactorial illness characterized by a long-term restriction of airflow and an inflammatory reaction in the lungs. The associated emphysema leads to the breakdown of alveolar proteins and abnormal expansion of the lung air spaces. Chronic bronchitis caused by the same disease can result in increased deposition of structural proteins, narrowing of the airways, and excessive mucus secretion leading to acute exacerbation of COPD (AECOPD).

Validation of the Contextual Sensation-Seeking Questionnaire for skiing and snowboarding among Chinese adult skiers and its relationship with risk-taking behavior.

Objective: To validate the reliability and validity of the Contextual Sensation-seeking Questionnaire for Skiing and Snowboarding (CSSQ-S) among Chinese adult skiers, and to explore the relationship between sensation seeking and risk-taking behavior.

Methods: Snowball sampling was employed to gather data from 515 individuals, aged between 18 and 40 years old, with at least one year of experience in skiing or snowboarding. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and other statistical methods were utilized for data analysis.

Global Trends in Incidence and Mortality Rates of Endometrial Cancer Among Individuals Aged 55 years and Above From 1990 to 2021: An Analysis of the Global Burden of Disease.

Purpose: To describe the temporal trend of endometrial burden in postmenopausal women aged 55 years and above worldwide from 1990 to 2021, evaluate the age cohort effect, explore its influencing factors, and predict the disease burden in the next 15 years.

Patients And Methods: Using Joinpoint regression, data from the 2021 Global Burden of Disease Study were assessed for changes in endometrial cancer incidence rate, morbidity, and mortality in postmenopausal women aged 55 years and above. Age period cohort analysis helped estimate age, period, and cohort effects.

Warming stimulates cellulose decomposition by recruiting phylogenetically diverse but functionally similar microorganisms.

Cellulose is the most abundant component of plant litter, which is critical for terrestrial carbon cycling. Nonetheless, it remains unknown how global warming affects cellulose-decomposing microorganisms. Here, we carried out a 3-year litterbag experiment to examine cellulose decomposition undergoing +3°C warming in a tallgrass prairie.

The mediating roles of cognitive emotion regulation and resilience in the association between life events and sleep quality among medical students.

Background: Sleep quality in medical students can be influenced by numerous factors including life events, resilience, and cognitive emotion regulation strategies. Understanding the interplay between these factors is crucial for developing effective interventions to enhance medical students' mental health and well-being.

Objective: This study examined the association between life events and sleep quality and explored the mediating roles of resilience and cognitive emotion regulation in this relationship.

Differential effects of high-fat diet on salivary and gut microbiota.

Objectives: Microorganisms contribute to the pathogenesis of obesity, while more studies focus on gut microbiome. However, the relationship between oral microbiota and obesity has yet to be elucidated. This study was designed to investigate the similarities and differences in the effects of a high-fat diet on salivary and gut microbiota through mouse experiments, exploring the hypothesis that oral microbial mechanisms may contribute to obesity.

A smart millimeter-wave base station for 6G application based on programmable metasurface.

The evolution of programmable metasurfaces has yielded many exciting electromagnetic (EM) phenomena and applications in both communities of physical and information sciences. Programmable metasurfaces, also known as reconfigurable intelligent surfaces or intelligent reflecting surfaces in wireless communications, have played important roles in enhancing signal coverage and transmission quality, and in building an artificially controlled communication environment. However, most of the realistic implementations are designed in the sub-6G band with a small array scale and 1-bit phase control ability, making the performance improvement not marvelous compared with the traditional solutions.

Adenosine A2A Receptor Activation Alleviated Disease of Mice with Systemic Infection by Regulating Macrophage Function.

Purpose: The incidence of candidemia, mediated by systemic () infection, was increasing. It is an urgent need to understand the underlying disease mechanisms to identify new therapeutic targets. This study aimed to investigate the roles of adenosine-adenosine receptor signal in systemic infection.

Noninvasive Quantitative Evaluation of Proliferative Lupus Nephritis Based on Ultrasonic Viscoelastic Imaging.

Objective: To evaluate the role of ultrasonic viscoelastic imaging in predicting proliferative lupus nephritis (PLN).

Methods: We prospectively used ultrasonic viscoelastic imaging to evaluate 143 patients with lupus nephritis (LN), who underwent kidney biopsies from May 2023 to June 2024. Sixty healthy volunteers served as the control group.

Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by joint swelling and bone destruction. Despite an incomplete understanding of its genesis, RA is tightly linked to the intricate immunological milieu, involving disruptions in molecular signaling and an imbalance between the innate and adaptive immune systems. With advancements in biomaterials science, the role of biomaterials in RA treatment has evolved from mere drug delivery systems to therapeutic microenvironment modulators, providing drug-independent treatment strategies for RA.

Ni(ii)/spiroBox-catalyzed asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes.

Nickel complexes of chiral spiroBox ligand catalyzed Friedel-Crafts alkylation reaction of indoles with nitroalkenes. Excellent yields (up to 99%) and enantiomeric excess (ee) values (up to 97%) were obtained with a broad scope of substrates. This catalytic system provides a facile synthesis of optically active 2-indolyl-1-nitro derivatives with high yield and enantioselectivity.

Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease.

Background And Aims: Bacteroides fragilis toxin (BFT), produced by enterotoxigenic B. fragilis (ETBF), is crucial for ETBF-induced colitis. This study aims to investigate the impact of BFT-host interactions on N6-methyladenosine (m6A) modification of host mRNA and its underlying mechanisms.

Endogenous ERMAP Affects T-Cell Function in EAE Mice.

Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease (AID) mediated by myelin-reactive CD4 T cells. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model of human MS. Erythrocyte membrane-associated protein (ERMAP) is a novel erythrocyte-specific adhesion/receptor molecule associated with erythrocyte adhesion.