Enhancing time-resolution for radon measurements using airflow-through scintillation cells based on a compartmental model approach.

To overcome the time-resolution limitation inherent in the airflow-through scintillation cell method for radon measurement, this study introduces a compartmental model elucidating the behaviors of radon and its progeny within such cells. The computed results of the normalized equilibrium functions derived from the compartmental model, provide quantitative insights into the equilibrium progression of 222Rn and its progeny over time, substantiating the identified time-resolution limitation of 2-3 hours. Laboratory experiments confirm the efficacy of the proposed correction algorithm, showcasing its ability to surmount the time-resolution limitation and achieve a rapid response in radon measurement using airflow-through scintillation cells.

Empagliflozin alleviates the development of autoimmune myocarditis via inhibiting NF-κB-dependent cardiomyocyte pyroptosis.

Autoimmune myocarditis, which falls within the broad spectrum of myocarditis, is characterized by an excessive inflammatory response in the heart, and can progress into dilated cardiomyopathy and irreversible heart failure in all possibility. However, effective clinical therapeutics are limited due to its complex inflammatory reactions. Empagliflozin (EMPA) has been previously demonstrated to possess anti-inflammatory properties.

Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization the STAT/MAPK/NF-κB Pathway.

Sepsis is a dysregulated systemic inflammatory response that often leads to cardiac dysfunction, which is termed sepsis-induced cardiomyopathy (SIC). Harmine, a natural -carboline alkaloid compound, has been shown to exert pharmacological effects on several diseases. Here, we investigated whether harmine protected against SIC development and the underlying mechanisms.