Publications by authors named "Chongqian Zhang"
Article Synopsis
- * The study explores the activity of AMD11070 and its derivatives using techniques like HQSAR, docking, and molecular dynamics simulations, revealing AMD11070's strong antiretroviral effects.
- * Key amino acids Asp97 and Glu288 influence binding interactions, and the presence of a butyl amine group in AMD11070 is crucial for its effectiveness, providing insights for future drug development targeting CXCR4.
Structure-based development of antagonists for chemokine receptor CXCR4.
Curr Comput Aided Drug Des
March 2013
The C-X-C chemokine receptor-4(CXCR4) is a G-protein coupled receptor (GPCR) which belongs to the family I GPCR or rhodopin-like GPCR family. CXCR4 plays a crucial role as a co-receptor with CCR5 for HIV-1 anchoring to mammalian cell membrane, and is implicated in cancer metastasis and inflammation. Recently, crystal structure of human CXCR4 receptor was reported, which facilitates the structure-based drug discovery of CXCR4 significantly.
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