Publications by authors named "Chongping Lai"
Article Synopsis
- The study demonstrates that using a specific protocol with two inhibitors can generate stable androgenetic haploid embryonic stem cells (AG-haESCs) from blastocysts, which retain essential DNA methylation patterns.
- These AG-haESCs show stable DNA methylation at paternal DMRs for over 60 passages and have the ability to efficiently contribute to mouse development when injected into oocytes.
- Furthermore, the research indicates that older AG-haESCs exhibit increased paternal DMR methylation and improved developmental potential due to a higher presence of specific hypermethylated cells.
Azoospermia patients who carry a monogenetic mutation that causes meiotic arrest may have their biological child through genetic correction in spermatogonial stem cells (SSCs). However, such therapy for infertility has not been experimentally investigated yet. In this study, a mouse model with an X-linked testis-expressed 11 (TEX11) mutation (Tex11) identified in azoospermia patients exhibited meiotic arrest due to aberrant chromosome segregation.
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