Publications by authors named "Chongjin Feng"
Background: Cervical lymph node metastasis (LNM) is a well-established poor prognosticator of oral squamous cell carcinoma (OSCC), in which occult metastasis is a subtype that makes prediction challenging. Here, we developed and validated a deep learning (DL) model using magnetic resonance imaging (MRI) for the identification of LNM in OSCC patients.
Methods: This retrospective diagnostic study developed a three-stage DL model by 45,664 preoperative MRI images from 723 patients in 10 Chinese hospitals between January 2015 and October 2020.
Article Synopsis
- Circulating tumor cells (CTCs) in patients with tongue squamous cell carcinoma (TSCC) show a high positivity rate before surgery (90.6%) and a decrease after treatment (72.9%), while no CTCs were found in the benign disease group.
- The study involved analyzing the relationship between CTC presence, clinical features, and progression-free survival (PFS) in 85 TSCC patients and 30 benign cases over a span of several years.
- It concluded that postoperative CTC levels are significant indicators of prognosis, suggesting that CTCs can be useful for monitoring the disease progression in TSCC patients.
Background: Efficient utilization of residual bone volume and the prevention of inferior alveolar nerve injury are critical considerations in immediate implant placement (IIP) within the posterior mandibular region. Addressing these challenges, this study focuses on the clinical efficacy and implant accuracy of dynamic real-time navigation, an emerging technology designed to enhance precision in implantation procedures.
Methods: This study included 84 patients with 130 implants undergoing immediate placement in the posterior mandibular region.
Objective: The preoperative hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a comprehensive marker of nutritional and immunological status, has been found to be robust for tumor prognosis prediction. Here, we evaluated the use of HALP in the prognostic prediction of tongue squamous cell carcinoma (TSCC).
Study Design: Patients with TSCC were retrospectively recruited from the years 2009-2019.
Circulating tumor cells in blood as a prognostic biomarker in tongue squamous cell carcinoma.
Oral Surg Oral Med Oral Pathol Oral Radiol
August 2022
Objective: The study aimed to evaluate the role of circulating tumor cells (CTCs) as a prognostic biomarker of tongue squamous cell carcinoma (TSCC).
Study Design: CTC levels in the peripheral blood of 50 patients with TSCC at baseline (i.e.
Background: A well-known transcriptional regulator of the proto-oncogene c-Myc, far-upstream element (FUSE) binding protein 1 (FUBP1) has been demonstrated by previous work to be aberrantly expressed in lots of cancers and plays a critical role in tumor progression; however, its expression and function in tongue squamous cell carcinoma (TSCC) remains unclear.
Methods: Evaluations with immunohistochemistry, quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were performed to assess expression. The correlations of expression levels with various clinicopathological factors were evaluated with univariate and multivariate analyses.
Background: The study explored the potential function of astrocyte elevated gene-1 (AEG-1) on angiogenesis in tongue squamous cell carcinoma (TSCC) in TSCC cell lines.
Methods: The different degrees of angiogenesis were detected in TSCC cell lines expressing different levels of AEG-1 by chick chorioallantoic membrane (CAM) experimental model. Next, we established xenografts of different TSCC cell lines with different expression levels of AEG-1 in nude mice and conducted immunohistochemistry to evaluate the expression of the angiogenesis-associated factor, that is, vascular endothelial growth receptor factor 2 (VEGFR-2) and microvessel density (MVD).
There is disputable on the role of nitrilase-like 2 (NIT2) in cancer. Its expression and its relationship with clinicopathological features in tongue squamous cell carcinoma (TSCC) are not yet clear. The purpose of this study is to investigate the expression of NIT2 in TSCC and its correlation with clinicopathological characteristics in TSCC patients.
View Article and Find Full Text PDFBackground: The aim of this study was to ascertain the expression and role of FMNL3 in tongue squamous cell carcinoma (TSCC) tissues.
Materials And Methods: Immunohistochemistry, qRT-PCR, and western blot were used to study the expression of FMNL3 in TSCC tissues and its adjacent normal tissues. The relationship between FMNL3 overexpression and various clinicopathological parameters and patients' survival were further assessed.
Objective: Recent studies have shown that the presence of systemic inflammation and platelet status correlate with poor survival in various cancers. The aim of this study was to evaluate the prognostic value of the preoperative platelet-lymphocyte ratio (PLR) and the neutrophil-lymphocyte ratio (NLR) in patients with oral squamous cell carcinoma (OSCC) undergoing surgery.
Methods: In this study, 306 patients with OSCC who had surgery were enrolled.
Despite advances in therapy, survival among patients with locally advanced squamous cell carcinoma of tongue (TSCC) and cervical lymph node metastasis remains dismal. Here, we estimated the functional effect of AEG-1 on TSCC metastasis and explored the molecular mechanism by which AEG-1 stimulates epithelial-mesenchymal transition (EMT). We initially found that AEG-1 mRNA levels were much higher in metastatic TSCC than in non-metastatic TSCC and that AEG-1 expression strongly correlates with EMT status.
View Article and Find Full Text PDFCollagen triple helix repeat-containing 1 (CTHRC1) is aberrantly overexpressed in multiple malignant tumors. However, the expression characteristics and function of CTHRC1 in epithelial ovarian cancer (EOC) remain unclear. We found that CTHRC1 expression was up-regulated in the paraffin-embedded EOC tissues compared to borderline or benign tumor tissues.
View Article and Find Full Text PDFAstrocyte elevated gene-1 (AEG-1) expression is increased in diverse human cancers and plays a vital role in tumorigenesis and progression. The aim of this study was to investigate the clinicopathologic features and prognostic significance of AEG-1 in squamous cell carcinoma of the tongue (TSCC). Immunohistochemistry (IHC) was performed to examine AEG-1 protein expression in paraffin-embedded tissues from 93 patients with TSCC.
View Article and Find Full Text PDFKnockdown of Cdc6 inhibits proliferation of tongue squamous cell carcinoma Tca8113 cells.
Technol Cancer Res Treat
April 2013
Article Synopsis
- The study investigated how reducing Cdc6 affects Tca8113 cell growth by using lentiviral vectors to deliver cdc6 siRNA.
- Real-time PCR and Western blotting showed a significant decrease in both mRNA and protein levels of Cdc6 after infection, with reductions up to 79.38%.
- Results indicated slowed cell growth and altered cell-cycle progression, with fewer cells in the S phase and increased apoptosis in Cdc6 downregulated cells.
Pulmonary metastases from an Ameloblastoma: case report and review of the literature.
J Craniomaxillofac Surg
December 2012
Article Synopsis
- Ameloblastomas are tumors known for high recurrence rates and local invasion, classifying them as borderline tumors, but they rarely metastasize.
- A case study details a patient whose mandibular ameloblastoma came back 29 years after surgery and metastasized to both lungs, making complete surgical removal impossible.
- The pulmonary metastases were confirmed via biopsy and not actively treated; monitoring over four years showed no significant changes in the lung tumors, while recent cases are reviewed regarding their occurrence and treatment.
Background: The present study aimed at evaluating the clinical importance of Mcm7 and Cdc6 expression in oral squamous cell carcinoma (OSCC) and precancerous lesions.
Materials And Methods: RT-PCR and immunohistochemistry analysis were performed on 47 frozen samples and 98 paraffin-embedded samples to evaluate the mRNA and protein expressions of Mcm7 and Cdc6.
Results: RT-PCR and immunohistochemistry indicated positive expressions of Mcm7 mRNA and protein in normal oral mucosa, precancerous lesions and OSCC.
Background: The tongue squamous cell carcinomas (SCCs) are characterized by high mitotic activity, and early detection is desirable. Overexpression of the DNA replication-initiation proteins has been associated with dysplasia and malignancy. Our aim was to determine whether these proteins are useful biomarkers for assessing the development of tongue SCC.
View Article and Find Full Text PDFPurpose: Oral mucositis is a common side effect of radiotherapy for head and neck cancer. The purpose of this study was to examine the significance of and the relationship between hypoxia inducible factor-1alpha (HIF-1alpha) and cyclooxygenase-2 (COX-2) gene expression and the corresponding protein levels in irradiated rat mucosa.
Material And Methods: A Sprague-Dawley rat model of irradiation-induced oral mucositis was generated.
Background & Objective: Previous studies have revealed the close relationship between Fas/FasL pathway and carcinogenesis of oral squamous cell carcinoma (OSCC). This study was designed to explore the potential of cdc25A-Fas chimeric expression vector in inducing apoptosis of human OSCC cell line Tca8113.
Methods: The 2 chimeric expression vector pAdTrack-CMV-cdc25A-Fas (pCCF), and pAdTrack-cdc25A-Fas (pCF) were constructed by gene engineering, pCCF, pCF, and the control plasmid pAdTrack-CMV were transfected into Tca8113 cells by liposome, respectively.