Publications by authors named "Chongjie Pang"
Article Synopsis
- Simnotrelvir (S/R) has shown strong antiviral effects against SARS-CoV-2 and, in a recent study, effectively reduced hospitalization rates for COVID-19 in patients during XBB variant surges.
- The study was conducted in China with 3522 adult participants diagnosed with mild to moderate COVID-19, comparing those treated with S/R to a control group not receiving antivirals.
- Results indicated that S/R significantly lowered the incidence of COVID-19-related hospitalizations and did not result in any deaths, especially benefiting older patients and those with existing health risks.
Overwhelming evidence has shown that aging is a significant risk factor for COVID-19-related hospitalizations, death and other adverse health outcomes. Particular T cell subsets that susceptible to aging and associated with COVID-19 disease severity requires further elucidation. Our study recruited 57 elderly patients with acute COVID-19 and 27 convalescent donors.
View Article and Find Full Text PDFArticle Synopsis
- - The creation of broad-spectrum SARS-CoV-2 vaccines aims to alleviate global economic and public health challenges caused by the COVID-19 pandemic.
- - Combining conserved T-cell epitopes with spike antigens could improve immune responses, making COVID-19 vaccines more effective.
- - Research indicates that dual vaccination strategies can boost both systemic and mucosal immunity, enhancing protection against respiratory viruses.
Article Synopsis
- This study investigates the prediction of multidrug-resistant (MDR-AB) pulmonary infections in patients who have suffered brain injuries, an issue common in neurosurgical intensive care units that often leads to severe outcomes.
- Researchers used clinical data and various analytical methods to create a nomogram—a visual tool that helps predict the likelihood of infection—based on key patient factors, with validation carried out on different patient groups.
- The final nomogram identified six important predictors and demonstrated strong diagnostic accuracy, showing promise for improving patient management in clinical settings.
, an environmental yeast widely used in industry and agriculture, is also an opportunistic pathogen resistant to multi-antifungals. During the national surveillance in China, has been documented from various hospitals and regions. At present, the molecular epidemiology of invasive infections caused by and their resistance profiles to antifungals were unknown.
View Article and Find Full Text PDFSerum bilirubin is negatively associated with white blood cell count.
Clinics (Sao Paulo)
December 2019
Objective: Bilirubin is considered an important antioxidant, anti-inflammatory factor and immunomodulator. The current investigation aimed to explore the association between bilirubin and white blood cell (WBC) count in a large Chinese cohort.
Methods: A total of 61091 participants (29259 males, 31832 females) were recruited from a Chinese tertiary hospital.
Abnormal hepatic function is common in infectious mononucleosis (IM). However, it remains unknown why increased transferase levels are more common than bilirubin abnormalities in IM. The current study aimed to investigate these associations in the Chinese population.
View Article and Find Full Text PDFInfectious mononucleosis (IM) due to Epstein-Barr virus infection is common. Uric acid (UA) is an important endogenous antioxidant. To the best of our knowledge, the association between UA and IM has not been comprehensively investigated to date.
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