Tribological Behavior and Mechanism of Silane-Bridged h-BN/MoS2 Hybrid Filling Epoxy Solid Lubricant Coatings.

To significantly improve the tribological performance of epoxy resin (EP), a novel h-BN/MoS composite was successfully synthesized using spherical MoS particles with lamellar self-assembly generated through the calcination method, followed by utilizing the "bridging effect" of a silane coupling agent to achieve a uniform and vertically oriented decoration of hexagonal boron nitride (h-BN) nanosheets on the MoS surface. The chemical composition and microstructure of the h-BN/MoS composite were systematically investigated. Furthermore, the enhancement effect of composites with various contents on the frictional properties of epoxy coatings was studied, and the mechanism was elucidated.

Temperature-Dependent Morphology Modulation of MoO from 1D Nanoribbons to 2D Nanoflakes for Enhanced Two-Dimensional Electrode Applications.

The morphology modulation of target crystals is important for understanding their growth mechanisms and potential applications. Herein, we report a convenient method for modulating the morphology of MoO by controlling different growth temperatures. With an increase in growth temperature, the morphology of MoO changes from a nanoribbon to a nanoflake.

Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.

Diabetic kidney disease (DKD) is a prevalent complication associated with diabetes in which podocyte dysfunction significantly contributes to the development and progression of the condition. Ring finger protein 183 (RNF183) is an ER-localized, transmembrane ring finger protein with classical E3 ligase activity. However, whether RNF183 is involved in glomerular podocyte dysfunction, which is the mechanism of action of DKD, is still poorly understood.

Neurogenic bladder pathophysiology, assessment and management after lumbar diseases.

Neurogenic bladder (NB) is a group of bladder and/or urethral dysfunctions caused by neurological lesions, commonly seen in patients with lumbar spine diseases, manifesting as urinary storage and voiding dysfunction, significantly affecting patients' quality of life. Degenerative changes or trauma to the lumbar spine can lead to narrowing of the dural sac, compressing the sacral nerve roots, cauda equina or blood vessels, causing bladder dysfunction and leading to NB. Diagnostic methods for NB include history taking, physical examination and noninvasive and invasive tests, such as urodynamic testing and cystoscopy.

Atomic intercalation - an approach to enhance photogenerated carrier dynamics for efficient photocatalysis carbon dioxide reduction.

Visible-light-driven CO2 reduction presents a long-term answer to environmental challenges. The limited effective optical carriers generated by the limited response dynamics of the existing photocatalyst have severely hindered the development of high efficiency photocatalysts. Here, we report a method of cobalt atoms intercalation in ultrathin BiOBr nanosheets for boosted photocatalytic CO2 reduction.

Exercise addiction in college students: the impact of body dissatisfaction, stress, physical activity and gender.

Introduction: Engaging in physical activity is commonly regarded as beneficial to health. However, exercise addiction may arise when enthusiasm for exercise reaches a level that disrupts life balance and overall well-being. Factors influencing college students' exercise addiction remain largely unknown.

Influence of calcium sources on the bio-mineralization behavior of and induced microbiologically influenced corrosion inhibition.

The influence of different calcium sources on the mineralization behavior of and their roles in microbiologically influenced corrosion inhibition (MICI) of Q235 carbon steel were investigated. Calcium lactate, calcium nitrate, and calcium L-aspartate were selected as alternative calcium sources to assess their effects on bacterial growth, carbonate deposition, and corrosion resistance. exhibited stable growth in all tested media, with the pH exceeding 8 after 14 days, promoting carbonate precipitation.

Size-dependent interactions between calciprotein particles and vascular endothelium.

The underlying mechanisms governing the interactions between nanoparticles and vascular endothelial barrier remain largely unexplored, which is crucial for the optimal design of nanoparticles for clinical applications. In this study, the size-dependent interactions between calciprotein particles (CPPs) and endothelial cells (ECs) were investigated using a rat model of chronic kidney disease (CKD) induced by 5/6 nephrectomy. Two primary types of CPP1 were studied: small-sized CPP1 (S-CPP1, <50 nm) and larger CPP1 (L-CPP1, <100 nm), detected three and five weeks post-surgery, respectively.

Timing of thoracic radiotherapy combined with immunotherapy influences pulmonary injury.

The present study aimed to assess the impact of chest radiotherapy combined with immunotherapy at different time points in lung injury. This retrospective study analyzed 35 patients with thoracic tumors (29 lung cancer cases and 6 esophageal cancer cases) who received radiotherapy combined with immunotherapy between January 2021 and December 2023 at at Capital Medical University, affiliated with Beijing Luhe Hospital (Beijing, China), with a median follow-up time of 21 months. Patients were divided into two groups: Group A (sequential, n=17), who received immunotherapy 2 weeks to 6 months before or after radiotherapy, and group B (synchronous, n=18), who received immunotherapy within 2 weeks before or after radiotherapy.

Pharmacological mechanism of action of Lianhua Qingwen in the treatment of COVID-19 and facial neuritis.

Objective: Coronavirus disease-2019 (COVID-19) can cause not only respiratory symptoms but also facial paralysis. Lianhua Qingwen (LHQW) has been reported to have therapeutic effects on COVID-19 and facial neuritis (FN). We explored the potential mechanism of LHQW in the treatment of COVID-19 and FN through a network-pharmacology approach.

Two new pregnane C steroids isolated from the roots of .

Two new C steroids periplosteroid A-B () and seven known C steroids (-) were isolated from the stems and roots of , among them, compounds , , and were firstly isolated from this plant. The structures of periplosteroid A-B were identified by comprehensive spectroscopic analyses, including 1D-NMR, 2D-NMR, HR-ESI-MS, UV, and IR spectral data. The results of cytotoxic activity showed that all the isolates exhibited certain inhibitory activity on six kinds of human tumour cell lines (786-O, MKN-45, 5637, L-02, MCF7 and 293 T).

RBM10 deficiency promotes brain metastasis by modulating sphingolipid metabolism in a BBB model of EGFR mutant lung adenocarcinoma.

Background: Brain metastasis significantly contributes to the failure of targeted therapy in patients with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (LUAD). Reduced expression of RNA-binding motif protein 10 (RBM10) is associated with brain metastasis in these patients. However, the mechanism by which RBM10 affects brain metastasis in EGFR-mutated LUAD remains unclear.

Temporal and Spatial Effects of Extreme Drought Events on Human Epidemics over Ancient China in 1784-1787 CE.

Extreme drought events can impact human health, notably triggering epidemics that impose significant global health and economic burdens. Understanding these effects and developing response strategies is crucial. However, there is limited epidemiological evidence on how climate change influenced ancient epidemics before large-scale urbanization and frequent population movements.

Comprehensive source tracing and process supervision of coating industrial wastewater using integrated water quality parameters and fluorescence spectroscopy.

Rapid industrialization has led to the concentration of heavily polluting industries, such as coatings, in industrial parks, resulting in significant volumes of hazardous wastewater. Effective inflow management and process monitoring are essential for the stable operation of wastewater treatment plants. This study collected samples from a coating industrial park and its treatment plant to analyze water quality.

SVLearn: a dual-reference machine learning approach enables accurate cross-species genotyping of structural variants.

Structural variations (SVs) are diverse forms of genetic alterations and drive a wide range of human diseases. Accurately genotyping SVs, particularly occurring at repetitive genomic regions, from short-read sequencing data remains challenging. Here, we introduce SVLearn, a machine-learning approach for genotyping bi-allelic SVs.

Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver.

Despite extensive investigations into the microbiome and metabolome changes associated with colon polyps and colorectal cancer (CRC), the microbiome and metabolome profiles of individuals with colonic polyposis, including those with (Gene-pos) and without (Gene-neg) a known genetic driver, remain comparatively unexplored. Using colon biopsies, polyps, and stool from patients with Gene-pos adenomatous polyposis ( = 9), Gene-neg adenomatous polyposis ( = 18), and serrated polyposis syndrome (SPS,  = 11), we demonstrated through 16S rRNA sequencing that the mucosa-associated microbiota in individuals with colonic polyposis is representative of the microbiota associated with small polyps, and that both Gene-pos and SPS cohorts exhibit differential microbiota populations relative to Gene-neg polyposis cohorts. Furthermore, we used these differential microbiota taxa to perform linear discriminant analysis to differentiate Gene-neg subjects from Gene-pos and from SPS subjects with an accuracy of 89% and 93% respectively.

LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis.

Osteoarthritis (OA) is one of the most common degenerative joint diseases in the elderly, increasing in prevalence and posing a substantial socioeconomic challenge, while no disease-modifying treatments available. Better understanding of the early molecular events will benefit the early-stage diagnosis and clinical therapy. Here, we observed the nucleus accumulation of ZBTB20, a member of ZBTB-protein family, in the chondrocytes of early-stage OA.

Expert consensus on clinical genome sequencing interpretation and reporting.

Genome sequencing (GS) refers to a technology that comprehensively and systematically detects the DNA sequences of an individual's nuclear and mitochondrial genomes. It aims to identify genetic variants and investigate their roles in human health and disease progression. As an emerging diagnostic tool, GS offers significant support for clinical diagnosis due to its high throughput, accuracy, and comprehensiveness.

Study on the quality characteristics of jujube slices under different pretreatment and drying methods.

This study investigates the effects of different pretreatment methods, cold plasma (CP) and ultrasound (US), as well as different drying techniques, including vacuum freeze-drying (FD), hot air drying (HAD), and microwave coupled with pulsed vacuum drying (MPVD), on the quality characteristics of winter jujube slices. The physical, chemical, and functional properties were analyzed, encompassing farinograph attributes, particle size, cation exchange capacity, total phenolic and flavonoid content, and flavor compounds were analyzed. In terms of physical properties, jujube slices subjected to MPVD demonstrate superior water-holding capacity at 2.

Spatial and single-cell transcriptomic analysis reveals fibroblasts dependent immune environment in colorectal cancer.

Colorectal cancer (CRC) exhibits a complex tumor microenvironment with significant cellular heterogeneity, particularly involving cancer-associated fibroblasts that influence tumor behavior and metastasis. This study integrated single-cell RNA sequencing and spatial transcriptomics to dissect fibroblast heterogeneity in CRC. Data processing employed Seurat for quality control, principal component analysis for dimensionality reduction, and t-Distributed Stochastic Neighbor Embedding for visualization.

p53 activates circASCC3 to repress R-loops and enhance resistance to chemotherapy.

The tumor suppressor p53 can trigger tumor resistance to chemotherapy by facilitating DNA damage repair and maintaining genomic integrity. Here, we report that a p53-induced circular RNA circASCC3 promotes chemotherapeutic resistance by resolving R-loops. Our results reveal that p53 directly activates the transcription of , the host gene of circASCC3.

BoundaryScreen: Summoning the Home Screen in VR via Walking Outward.

A safety boundary wall in VR is a virtual barrier that defines a safe area, allowing users to navigate and interact without safety concerns. However, existing implementations neglect to utilize the safety boundary wall's large surface for displaying interactive information. In this work, we propose the BoundaryScreen technique based on the "walking outward" metaphor to add interactivity to the safety boundary wall.

Transient receptor potential vanilloid-1 (TRPV1) is a mediator of noise-induced neural damage in zebrafish and mice.

Sound pollution (noise) is an increasing environmental concern, particularly associated with neurological and neurobehavioral abnormalities. However, the molecular mechanisms underlying noise-induced neural damage remain unclear. In this study, we conducted transcriptional profiling of zebrafish to investigate the mechanisms underlying acoustic stimulation (1,000 Hz, 130 dB).

Comparative electromagnetic shielding performance of TiCT-PVA composites in various structural forms: compact films, hydrogels, and aerogels.

The structural design of light-weight MXene-polymer composites has attracted significant interest for enhancing both electromagnetic interference (EMI) shielding performance and mechanical strength, which are critical for practical applications. However, a systematic understanding of how various structural configurations of MXene composites affect EMI shielding is lacking. In this study, light-weight TiCT-PVA composites were fabricated in three structural forms, hydrogel, aerogel, and compact film, while varying the TiCT areal density (14 to 20 mg cm) to elucidate the role of structural design in X-band EMI shielding and mechanical properties.