Publications by authors named "Chonggang Wang"

Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants that cannot be banned. Exposure to PAHs has been reported to alter spermatogenesis in mammals, but little is known about prenatal exposure to a mixture of PAHs on the reproductive toxicity of adult offspring. In this study, we investigated the associations between prenatal exposure to environmentally relevant levels of PAHs in mice and testicular dysfunction, including impaired spermatogenesis and steroid hormone dysfunction in male offspring on postnatal day 180.

View Article and Find Full Text PDF

Polycyclic aromatic hydrocarbons (PAHs) widely present in the environment, but their effect on cerebrovascular development has been rarely reported. In this study, dechorionated zebrafish embryos at 24 hpf were exposed to benzo(a)pyrene (BaP) at 0.5, 5 and 50 nM for 48 h, cerebrovascular density showed a significant reduction in the 5 and 50 nM groups.

View Article and Find Full Text PDF

Phenanthrene (Phe) is a commonly occurring polycyclic aromatic hydrocarbon (PAH) found in various food sources and drinking water. Previous studies have shown that long-term exposure to Phe in male mice leads to insulin resistance in a dose-dependent manner. However, the effect of Phe on glucose homeostasis in female mice remains unknown.

View Article and Find Full Text PDF
Article Synopsis
  • - The study focuses on the risks of triazole fungicides, specifically fenbuconazole (FBZ), and their impact on fish embryos, examining transgenerational cardiac toxicity.
  • - Fertilized eggs were exposed to varying concentrations of FBZ, leading to increased arrhythmia observed in multiple generations of zebrafish larvae, and alterations in heart-related gene expression.
  • - Findings suggest that cardiac developmental defects arise due to decreased protein levels and transcription of key cardiac genes, with implications for understanding and preventing congenital heart disease.
View Article and Find Full Text PDF
Article Synopsis
  • Phenanthrene (Phe) is a common environmental pollutant that negatively affects the uterine structure and function in female mice.
  • Exposure to Phe over 270 days led to inflammation, fibrosis, and signs of potential carcinogenesis in the uterus, indicated by increased blood vessel area and specific cellular markers.
  • The study found disruptions in steroid hormone levels and identified genetic pathways tied to inflammation and cancer risk, demonstrating that even low levels of Phe can be harmful to reproductive health.
View Article and Find Full Text PDF
Article Synopsis
  • - This study examined how prenatal exposure to Epigallocatechin gallate (EGCG), a compound with health benefits, affects the liver of adult mice offspring, finding that such exposure can decrease liver size and disrupt its function.
  • - Mice received 1 mg/kg of EGCG during pregnancy for 16 days, leading to increased inflammation and glycogen buildup in their livers as revealed by transcriptomics and metabolomics analyses.
  • - The research indicates that prenatal EGCG exposure negatively affects liver metabolism and inflammation pathways, highlighting potential risks of consuming EGCG during pregnancy, including possible changes in gene expression linked to liver health.
View Article and Find Full Text PDF
Article Synopsis
  • - The study examines how embryonic exposure to the fungicide fenbuconazole (FBZ) affects neurobehavior in zebrafish, finding significant changes in brain structure and function in adulthood.
  • - Adult zebrafish exposed to FBZ showed decreased brain-to-body weight ratios, increased brain cell death, and altered protein levels, suggesting persistent neurotoxicity from early exposure.
  • - Behavioral tests revealed reduced movement and social interaction in zebrafish exposed to higher FBZ levels, potentially linked to anxiety-like behaviors due to changes in dopamine and norepinephrine levels.
View Article and Find Full Text PDF

Tea and tea products are widely used as the most popular beverage in the world. EGCG is the most abundant bioactive tea polyphenol in green tea, which has positive effects on the prevention and treatment of diabetes. However, the impact of EGCG exposure on glucose homeostasis and islets in adult mice have not been reported.

View Article and Find Full Text PDF

Polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants that are widely present in aquatic ecosystems. To assess the impact of early-life exposure to benzo[a]pyrene (BaP), a representative PAH, on reproductive ability in adult male zebrafish (Danio rerio), fertilized embryos were exposed to 0.05, 0.

View Article and Find Full Text PDF

To explore the impact of embryonic exposure to phenanthrene (Phe), a typical tricyclic polycyclic aromatic hydrocarbon, on cardiac development in next generation, fertilized zebrafish embryos were exposed to 0.05, 0.5, 5 and 50 nM Phe for 96 h, and then transferred to clear water and raised to adulthood.

View Article and Find Full Text PDF

Polycyclic aromatic hydrocarbons (PAHs) are pervasive pollutants in the environment. To compare the developmental toxicity of PAHs with different ring numbers to fish embryos, benzo(a)pyrene (BaP), pyrene (Pyr) and phenanthrene (Phe) were selected as the representatives of 3, 4 and 5-ringed PAHs, and fertilized embryos of zebrafish (Danio rerio) were exposed to 5 nM PAHs for 72 h. The PAH-treated embryos showed defects in craniofacial cartilage.

View Article and Find Full Text PDF

Epigallocatechin gallate (EGCG) has a wide consumption for its health advantages. The current study investigates the effects of prenatal EGCG administration on glucose metabolism and obesity in adulthood. Pregnant C57BL/6J mice were supplemented with EGCG in drinking water (3 µg/mL) for 16 d.

View Article and Find Full Text PDF

Phenanthrene (Phe) is a polycyclic aromatic hydrocarbon widely present in foods and drinking water. To explore the detrimental effects of Phe on body metabolism, female Kunming mice were treated with Phe in drinking water at concentrations of 0.05, 0.

View Article and Find Full Text PDF

Although epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, has been shown to have many benefits, the effect of EGCG exposure in utero on adult uterine development is unclear. In this study, pregnant C57BL/6 mice were exposed to 1 mg/kg body weight (bw) EGCG dissolved in drinking water from gestational days 0.5-16.

View Article and Find Full Text PDF

Polycyclic aromatic hydrocarbons (PAHs) have been detected throughout the human body. Whether exposure to PAHs is associated with the incidence of type 1 diabetes mellitus should be investigated. To this end, pregnant mice were exposed to mixed PAHs (5, 50, or 500 μg/kg) once every other day during gestation.

View Article and Find Full Text PDF

As a representative polycyclic aromatic hydrocarbon with low ring numbers, phenanthrene (Phe) is ubiquitously present in the environment. In this study, zebrafish embryos were exposed to Phe at 0.05, 0.

View Article and Find Full Text PDF

Fenbuconazole (FBZ) is widely used in agriculture. The current study was conducted to evaluate the influence of embryonic exposure to FBZ on reproduction in adult zebrafish. Embryos were exposed to 5, 50 and 500 ng/L FBZ for 72 h and then raised in clean water until adulthood.

View Article and Find Full Text PDF

Epigallocatechin-3-gallate (EGCG), which is a major polyphenol in tea, has an unclear effect on cardiac development. In the present study, mice (C57BL/6) were exposed in utero to EGCG dissolved in drinking water (3 μg/ml) for 16 days. A significant decrease in the heart/body weight ratio was observed in adult males but not in adult females.

View Article and Find Full Text PDF

Polycyclic aromatic hydrocarbons (PAHs) are a risk factor for the occurrence of cardiac diseases. The present study was conducted to investigate the influence of prenatal exposure to a mixed PAHs on heart and the underlying mechanism. Pregnant mice were orally administered with a mixture of 8 kinds of PAHs (0, 5, 50, 500 μg/kg body weight) once every 2 days for a total of 8 dosages.

View Article and Find Full Text PDF

Phenanthrene (Phe) is a tricyclic polycyclic aromatic hydrocarbon with high bioavailability under natural exposure. However, there are few studies on the reproductive toxicity of Phe in mammals. In this study, male Kunming mice were gavaged once every two days with Phe (5, 50, and 500 ng/kg) for 28 weeks.

View Article and Find Full Text PDF

Epidemiological studies have indicated that polycyclic aromatic hydrocarbons were related to diabetes and insulin resistance. However, studies in mammals on the development of diabetes caused by polycyclic aromatic hydrocarbons are lacking. Pregnant mice were orally exposed to phenanthrene (0, 60 and 600 μg kg body weight) once every 3 days during gestation.

View Article and Find Full Text PDF

Epidemiological studies show that the burden of polycyclic aromatic hydrocarbons in human body is associated with the occurrence of insulin resistance and diabetes. In the present study, pregnant mice were exposed to phenanthrene (Phe) at doses of 0, 60 and 600 μg/kg body weight of by gavage once every 3 days. The female F1 mice at 120 days of age showed no change in their fasting glucose levels (FGLs) but exhibited significantly decreased homeostasis model assessment (HOMA) β-cell (49% and 43%) and significantly downregulated pancreatic proinsulin gene (ins2) transcription.

View Article and Find Full Text PDF

Phenanthrene (Phe) is a representative polycyclic aromatic hydrocarbon, and its ubiquity makes the risk assessment of Phe in aquatic ecosystems important. To assess the long-term effects of early-life Phe exposure on fish, the embryos of the model organism, zrbrafish (Danio rerio) were exposed to Phe at 0.05, 0.

View Article and Find Full Text PDF

Numerous studies have shown that endocrine-disrupting chemicals are one of the important pathogenic factors in women with polycystic ovary syndrome. Our previous study has revealed that bisphenol A (BPA) can cause steroid hormone imbalance, polycystic ovary, and estrus cycle disorder. In this study, we aimed to explore the effect of BPA, a typical environmental estrogen, on the synthesis of steroid hormones in human ovarian granulosa KGN cells.

View Article and Find Full Text PDF