Tuning the Sensitivity of MoS Nanopores: From Labeling to Labeling-Free Detection of DNA Methylation.

DNA methylation discrimination is often challenged by complicated pretreatment, insufficient sensitivity, and suboptimal accuracy. Here, single-molecule readout of DNA methylation is reported using single-layer MoS nanopores. By tuning pore dimension, the sensitivity of MoS nanopores is manipulated, empowering both labeling and labeling-free strategies for DNA methylation discrimination.